m7G-modified mt-tRF3b-LeuTAA regulates mitophagy and metabolic reprogramming via SUMOylation of SIRT3 in chondrocytes

N7-methylguanosine (m7G) modification is one of the most prevalent RNA modifications, and methyltransferase-like protein-1 (METTL1) is a key component of the m7G methyltransferase complex. METTL1-catalyzed m7G as a new RNA modification pathway that regulates RNA structure, biogenesis, and cell migra...

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Veröffentlicht in:	Biomaterials 2025-03, Vol.314, p.122903, Article 122903
Hauptverfasser:	Long, Dianbo, Deng, Zengfa, Zhao, Xiaoyi, Xu, Yiyang, Li, Wei, Mo, Xiaolin, Zhong, Yanlin, Li, Ming, He, Aishan, Zhang, Ziji, Kang, Yan, Mao, Guping
Format:	Artikel
Sprache:	eng
Schlagworte:	Metabolic reprogramming Mitophagy N7-methylguanosine Nanoparticle tRNA-derived fragments
Online-Zugang:	Volltext
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