Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates

[Display omitted] •Twenty-four compounds were designed and assayed for their multi-target anti-AD activity.•Compounds 6 and 8 showed an interesting profile as multi-target agents as ChEs, MAO-B and FAAH inhibitors.•Compound 5 (ROS151) was found to be a potent AChE inhibitor, as well as a chelator of...

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Veröffentlicht in:	Bioorganic chemistry 2024-12, Vol.153, p.107895, Article 107895
Hauptverfasser:	Leuci, Rosalba, Simic, Stefan, Carrieri, Antonio, Chaves, Sílvia, La Spada, Gabriella, Brunetti, Leonardo, Tortorella, Paolo, Loiodice, Fulvio, Laghezza, Antonio, Catto, Marco, Santos, M.Amélia, Tufarelli, Vincenzo, Wackerlig, Judith, Piemontese, Luca
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - chemistry Acetylcholinesterase - metabolism Alzheimer Disease - drug therapy Alzheimer’s disease Animals Butyrylcholinesterase - metabolism Chelating agents ChEs Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Cytotoxicity Docking Dose-Response Relationship, Drug Enzyme inhibitors FAAH Humans MAOs Molecular Docking Simulation Molecular Structure Monoamine Oxidase - metabolism Multipotent drugs Neurodegeneration Neuroprotective Agents - chemical synthesis Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Pharmacokinetics Rats Rivastigmine - chemical synthesis Rivastigmine - chemistry Rivastigmine - pharmacology Rivastigmine mimetics Structure-Activity Relationship
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