Structural basis for regulation of a CBASS-CRISPR-Cas defense island by a transmembrane anti-σ factor and its ECF σ partner

How CRISPR-Cas and cyclic oligonucleotide-based antiphage signaling systems (CBASS) are coordinately deployed against invaders remains unclear. We show that a locus containing two CBASS and one type III-B CRISPR-Cas system, regulated by the transmembrane anti-σ DdvA and its cognate extracytoplasmic...

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Veröffentlicht in:	Science advances 2024-10, Vol.10 (43), p.eadp1053
Hauptverfasser:	Bernal-Bernal, Diego, Pantoja-Uceda, David, López-Alonso, Jorge Pedro, López-Rojo, Alfonso, López-Ruiz, José Antonio, Galbis-Martínez, Marisa, Ochoa-Lizarralde, Borja, Tascón, Igor, Elías-Arnanz, Montserrat, Ubarretxena-Belandia, Iban, Padmanabhan, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriophages - genetics Bacteriophages - metabolism Catalytic Domain CRISPR-Cas Systems Cryoelectron Microscopy Models, Molecular Myxococcus xanthus - metabolism Protein Multimerization Sigma Factor - chemistry Sigma Factor - genetics Sigma Factor - metabolism
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