Neural and molecular investigation into the paraventricular thalamus for chronic restraint stress induced depressive-like behaviors

[Display omitted] •CRS induced depressive-like behaviors and reduced the activity of PVT CamkIIα neurons in mice.•PVTCamkIIα neurons was essential for depressive-like behaviors.•PVT → NAc circuit regulated depressive-like behaviors induced by CRS.•Imipramine reversed the behavioral deficits, neurona...

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Veröffentlicht in:	Journal of advanced research 2024-10
Hauptverfasser:	He, Yong, Ren, Yikun, Chen, Xiangyu, Wang, Yue, Yu, Heming, Cai, Junchao, Wang, Peng, Ren, Yi, Xie, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemogenetics Chronic restraint stress Major depressive disorder Neuropeptide Y Paraventricular nucleus of thalamus
Online-Zugang:	Volltext
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