Fatigue in severe pediatric asthma patients: Results of the PANDA study
Background Fatigue is a commonly reported clinical symptom, yet research on fatigue in children with severe asthma is missing. We aimed to explore the extent of fatigue in severe pediatric asthma and identify associated factors. Method This study was conducted within the Pediatric Asthma Non‐Invasiv...
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| Veröffentlicht in: | Pediatric allergy and immunology 2024-10, Vol.35 (10), p.e14262-n/a |
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| creator | Dijk, Yoni E. Keuker, Valerie S. L. Hashimoto, Simone Rutjes, Niels W. Muilekom, Maud M. Golebski, Kornel Van Litsenburg, Raphaële R. L. Terheggen‐Lagro, Suzanne W. J. Ewijk, Bart E. Gemke, Reinoud J. B. J. Maitland‐van der Zee, Anke H. Vijverberg, Susanne J. H. |
| description | Background
Fatigue is a commonly reported clinical symptom, yet research on fatigue in children with severe asthma is missing. We aimed to explore the extent of fatigue in severe pediatric asthma and identify associated factors.
Method
This study was conducted within the Pediatric Asthma Non‐Invasive Diagnostic Approaches (PANDA), an observational cohort of 6‐ to 17‐year‐old Dutch children with severe asthma. The Pediatric Quality of Life Inventory Multidimensional Fatigue Scale (PedsQL™‐MFS) was used to measure self‐reported fatigue. Fatigue levels were compared with a general pediatric Dutch population using linear regression, and quantifying the prevalence of “fatigued” (−2 |
| doi_str_mv | 10.1111/pai.14262 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3120596697</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3120596697</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2782-e9eb8d67336ac6ac7c21d395a4e4ed8272b7f5072831461e788de6b61ddb48e43</originalsourceid><addsrcrecordid>eNp10E1Lw0AQBuBFFFurB_-ALHjRQ9r9SHaz3kK1tSBaRM9hk53YlKSJ2UTpv3drqgfBYWAuDy_Di9A5JWPqZlLrfEx9JtgBGlKulMcJDw_RkCgSeIIGcoBOrF0TQiUX9BgNuPIDIpQ_RPOZbvO3DnC-wRY-oAFcg8l12-Qp1rZdlRrXjsCmtTf4GWxXtBZXGW5XgJfR422EbduZ7Sk6ynRh4Wx_R-h1dvcyvfcenuaLafTgpUyGzAMFSWiE5Fzo1K1MGTVcBdoHH0zIJEtkFhDJQk59QUGGoQGRCGpM4ofg8xG66nPrpnrvwLZxmdsUikJvoOpszCkjgRJCSUcv_9B11TUb991OUSoVlcyp616lTWVtA1lcN3mpm21MSbxrN3btxt_tOnuxT-ySEsyv_KnTgUkPPvMCtv8nxcto0Ud-ARNogXA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3121179172</pqid></control><display><type>article</type><title>Fatigue in severe pediatric asthma patients: Results of the PANDA study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Dijk, Yoni E. ; Keuker, Valerie S. L. ; Hashimoto, Simone ; Rutjes, Niels W. ; Muilekom, Maud M. ; Golebski, Kornel ; Van Litsenburg, Raphaële R. L. ; Terheggen‐Lagro, Suzanne W. J. ; Ewijk, Bart E. ; Gemke, Reinoud J. B. J. ; Maitland‐van der Zee, Anke H. ; Vijverberg, Susanne J. H.</creator><creatorcontrib>Dijk, Yoni E. ; Keuker, Valerie S. L. ; Hashimoto, Simone ; Rutjes, Niels W. ; Muilekom, Maud M. ; Golebski, Kornel ; Van Litsenburg, Raphaële R. L. ; Terheggen‐Lagro, Suzanne W. J. ; Ewijk, Bart E. ; Gemke, Reinoud J. B. J. ; Maitland‐van der Zee, Anke H. ; Vijverberg, Susanne J. H.</creatorcontrib><description>Background
Fatigue is a commonly reported clinical symptom, yet research on fatigue in children with severe asthma is missing. We aimed to explore the extent of fatigue in severe pediatric asthma and identify associated factors.
Method
This study was conducted within the Pediatric Asthma Non‐Invasive Diagnostic Approaches (PANDA), an observational cohort of 6‐ to 17‐year‐old Dutch children with severe asthma. The Pediatric Quality of Life Inventory Multidimensional Fatigue Scale (PedsQL™‐MFS) was used to measure self‐reported fatigue. Fatigue levels were compared with a general pediatric Dutch population using linear regression, and quantifying the prevalence of “fatigued” (−2 < Standard deviations [SD] ≤ −1) and “severely fatigued” (SD ≤ −2) children. Secondly, we performed linear regression analyses to explore whether fatigue levels were independently associated with asthma attacks, comorbidities, medication, pulmonary function, symptom control, and asthma‐related quality of life (QoL).
Results
Severe pediatric asthma patients (n = 78, mean age 11.8 ± 3.1 years) reported significantly more fatigue than Dutch peers (n = 328, mean age 11.8 ± 3.2 years) mean difference in z‐score: −0.68; 95%CI −0.96, −0.40. In the severe asthma group, 28.2% scored as “fatigued” and 15.4% as “severely fatigued,” compared with 14.0% and 3.4% in the general population. In pediatric asthma patients, asthma‐related QoL (β = 0.77, p < .01, ΔR2 = .43), symptom control (β = 0.56, p < .01, ΔR2 = .24) and a dysfunctional breathing pattern (β = −0.36, p < .01, ΔR2 = .12) were most strongly associated with fatigue scores.
Conclusion
Fatigue is a common symptom in children with severe asthma and is associated with multiple clinical factors and patient‐reported outcomes. It should be considered as an important treatment target.</description><identifier>ISSN: 0905-6157</identifier><identifier>ISSN: 1399-3038</identifier><identifier>EISSN: 1399-3038</identifier><identifier>DOI: 10.1111/pai.14262</identifier><identifier>PMID: 39450694</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Asthma ; Asthma - complications ; Asthma - diagnosis ; Asthma - epidemiology ; Child ; Children ; Cohort Studies ; Comorbidity ; Fatigue ; Fatigue - epidemiology ; Fatigue - etiology ; Female ; Humans ; Male ; Netherlands - epidemiology ; Patients ; patient‐reported outcome measures ; Pediatrics ; Prevalence ; Quality of Life ; Regression analysis ; Respiratory function ; Self Report ; severe asthma ; Severity of Illness Index ; Surveys and Questionnaires</subject><ispartof>Pediatric allergy and immunology, 2024-10, Vol.35 (10), p.e14262-n/a</ispartof><rights>2024 The Author(s). published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.</rights><rights>2024 The Author(s). Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2782-e9eb8d67336ac6ac7c21d395a4e4ed8272b7f5072831461e788de6b61ddb48e43</cites><orcidid>0000-0002-0414-3442 ; 0000-0002-3305-3745 ; 0000-0002-3996-1963 ; 0000-0002-4579-4081 ; 0009-0004-2381-9403 ; 0000-0001-8995-3817</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpai.14262$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpai.14262$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39450694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dijk, Yoni E.</creatorcontrib><creatorcontrib>Keuker, Valerie S. L.</creatorcontrib><creatorcontrib>Hashimoto, Simone</creatorcontrib><creatorcontrib>Rutjes, Niels W.</creatorcontrib><creatorcontrib>Muilekom, Maud M.</creatorcontrib><creatorcontrib>Golebski, Kornel</creatorcontrib><creatorcontrib>Van Litsenburg, Raphaële R. L.</creatorcontrib><creatorcontrib>Terheggen‐Lagro, Suzanne W. J.</creatorcontrib><creatorcontrib>Ewijk, Bart E.</creatorcontrib><creatorcontrib>Gemke, Reinoud J. B. J.</creatorcontrib><creatorcontrib>Maitland‐van der Zee, Anke H.</creatorcontrib><creatorcontrib>Vijverberg, Susanne J. H.</creatorcontrib><title>Fatigue in severe pediatric asthma patients: Results of the PANDA study</title><title>Pediatric allergy and immunology</title><addtitle>Pediatr Allergy Immunol</addtitle><description>Background
Fatigue is a commonly reported clinical symptom, yet research on fatigue in children with severe asthma is missing. We aimed to explore the extent of fatigue in severe pediatric asthma and identify associated factors.
Method
This study was conducted within the Pediatric Asthma Non‐Invasive Diagnostic Approaches (PANDA), an observational cohort of 6‐ to 17‐year‐old Dutch children with severe asthma. The Pediatric Quality of Life Inventory Multidimensional Fatigue Scale (PedsQL™‐MFS) was used to measure self‐reported fatigue. Fatigue levels were compared with a general pediatric Dutch population using linear regression, and quantifying the prevalence of “fatigued” (−2 < Standard deviations [SD] ≤ −1) and “severely fatigued” (SD ≤ −2) children. Secondly, we performed linear regression analyses to explore whether fatigue levels were independently associated with asthma attacks, comorbidities, medication, pulmonary function, symptom control, and asthma‐related quality of life (QoL).
Results
Severe pediatric asthma patients (n = 78, mean age 11.8 ± 3.1 years) reported significantly more fatigue than Dutch peers (n = 328, mean age 11.8 ± 3.2 years) mean difference in z‐score: −0.68; 95%CI −0.96, −0.40. In the severe asthma group, 28.2% scored as “fatigued” and 15.4% as “severely fatigued,” compared with 14.0% and 3.4% in the general population. In pediatric asthma patients, asthma‐related QoL (β = 0.77, p < .01, ΔR2 = .43), symptom control (β = 0.56, p < .01, ΔR2 = .24) and a dysfunctional breathing pattern (β = −0.36, p < .01, ΔR2 = .12) were most strongly associated with fatigue scores.
Conclusion
Fatigue is a common symptom in children with severe asthma and is associated with multiple clinical factors and patient‐reported outcomes. It should be considered as an important treatment target.</description><subject>Adolescent</subject><subject>Asthma</subject><subject>Asthma - complications</subject><subject>Asthma - diagnosis</subject><subject>Asthma - epidemiology</subject><subject>Child</subject><subject>Children</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Fatigue</subject><subject>Fatigue - epidemiology</subject><subject>Fatigue - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Netherlands - epidemiology</subject><subject>Patients</subject><subject>patient‐reported outcome measures</subject><subject>Pediatrics</subject><subject>Prevalence</subject><subject>Quality of Life</subject><subject>Regression analysis</subject><subject>Respiratory function</subject><subject>Self Report</subject><subject>severe asthma</subject><subject>Severity of Illness Index</subject><subject>Surveys and Questionnaires</subject><issn>0905-6157</issn><issn>1399-3038</issn><issn>1399-3038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp10E1Lw0AQBuBFFFurB_-ALHjRQ9r9SHaz3kK1tSBaRM9hk53YlKSJ2UTpv3drqgfBYWAuDy_Di9A5JWPqZlLrfEx9JtgBGlKulMcJDw_RkCgSeIIGcoBOrF0TQiUX9BgNuPIDIpQ_RPOZbvO3DnC-wRY-oAFcg8l12-Qp1rZdlRrXjsCmtTf4GWxXtBZXGW5XgJfR422EbduZ7Sk6ynRh4Wx_R-h1dvcyvfcenuaLafTgpUyGzAMFSWiE5Fzo1K1MGTVcBdoHH0zIJEtkFhDJQk59QUGGoQGRCGpM4ofg8xG66nPrpnrvwLZxmdsUikJvoOpszCkjgRJCSUcv_9B11TUb991OUSoVlcyp616lTWVtA1lcN3mpm21MSbxrN3btxt_tOnuxT-ySEsyv_KnTgUkPPvMCtv8nxcto0Ud-ARNogXA</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Dijk, Yoni E.</creator><creator>Keuker, Valerie S. L.</creator><creator>Hashimoto, Simone</creator><creator>Rutjes, Niels W.</creator><creator>Muilekom, Maud M.</creator><creator>Golebski, Kornel</creator><creator>Van Litsenburg, Raphaële R. L.</creator><creator>Terheggen‐Lagro, Suzanne W. J.</creator><creator>Ewijk, Bart E.</creator><creator>Gemke, Reinoud J. B. J.</creator><creator>Maitland‐van der Zee, Anke H.</creator><creator>Vijverberg, Susanne J. H.</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0414-3442</orcidid><orcidid>https://orcid.org/0000-0002-3305-3745</orcidid><orcidid>https://orcid.org/0000-0002-3996-1963</orcidid><orcidid>https://orcid.org/0000-0002-4579-4081</orcidid><orcidid>https://orcid.org/0009-0004-2381-9403</orcidid><orcidid>https://orcid.org/0000-0001-8995-3817</orcidid></search><sort><creationdate>202410</creationdate><title>Fatigue in severe pediatric asthma patients: Results of the PANDA study</title><author>Dijk, Yoni E. ; Keuker, Valerie S. L. ; Hashimoto, Simone ; Rutjes, Niels W. ; Muilekom, Maud M. ; Golebski, Kornel ; Van Litsenburg, Raphaële R. L. ; Terheggen‐Lagro, Suzanne W. J. ; Ewijk, Bart E. ; Gemke, Reinoud J. B. J. ; Maitland‐van der Zee, Anke H. ; Vijverberg, Susanne J. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2782-e9eb8d67336ac6ac7c21d395a4e4ed8272b7f5072831461e788de6b61ddb48e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Asthma</topic><topic>Asthma - complications</topic><topic>Asthma - diagnosis</topic><topic>Asthma - epidemiology</topic><topic>Child</topic><topic>Children</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Fatigue</topic><topic>Fatigue - epidemiology</topic><topic>Fatigue - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Netherlands - epidemiology</topic><topic>Patients</topic><topic>patient‐reported outcome measures</topic><topic>Pediatrics</topic><topic>Prevalence</topic><topic>Quality of Life</topic><topic>Regression analysis</topic><topic>Respiratory function</topic><topic>Self Report</topic><topic>severe asthma</topic><topic>Severity of Illness Index</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dijk, Yoni E.</creatorcontrib><creatorcontrib>Keuker, Valerie S. L.</creatorcontrib><creatorcontrib>Hashimoto, Simone</creatorcontrib><creatorcontrib>Rutjes, Niels W.</creatorcontrib><creatorcontrib>Muilekom, Maud M.</creatorcontrib><creatorcontrib>Golebski, Kornel</creatorcontrib><creatorcontrib>Van Litsenburg, Raphaële R. L.</creatorcontrib><creatorcontrib>Terheggen‐Lagro, Suzanne W. J.</creatorcontrib><creatorcontrib>Ewijk, Bart E.</creatorcontrib><creatorcontrib>Gemke, Reinoud J. B. J.</creatorcontrib><creatorcontrib>Maitland‐van der Zee, Anke H.</creatorcontrib><creatorcontrib>Vijverberg, Susanne J. H.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dijk, Yoni E.</au><au>Keuker, Valerie S. L.</au><au>Hashimoto, Simone</au><au>Rutjes, Niels W.</au><au>Muilekom, Maud M.</au><au>Golebski, Kornel</au><au>Van Litsenburg, Raphaële R. L.</au><au>Terheggen‐Lagro, Suzanne W. J.</au><au>Ewijk, Bart E.</au><au>Gemke, Reinoud J. B. J.</au><au>Maitland‐van der Zee, Anke H.</au><au>Vijverberg, Susanne J. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatigue in severe pediatric asthma patients: Results of the PANDA study</atitle><jtitle>Pediatric allergy and immunology</jtitle><addtitle>Pediatr Allergy Immunol</addtitle><date>2024-10</date><risdate>2024</risdate><volume>35</volume><issue>10</issue><spage>e14262</spage><epage>n/a</epage><pages>e14262-n/a</pages><issn>0905-6157</issn><issn>1399-3038</issn><eissn>1399-3038</eissn><abstract>Background
Fatigue is a commonly reported clinical symptom, yet research on fatigue in children with severe asthma is missing. We aimed to explore the extent of fatigue in severe pediatric asthma and identify associated factors.
Method
This study was conducted within the Pediatric Asthma Non‐Invasive Diagnostic Approaches (PANDA), an observational cohort of 6‐ to 17‐year‐old Dutch children with severe asthma. The Pediatric Quality of Life Inventory Multidimensional Fatigue Scale (PedsQL™‐MFS) was used to measure self‐reported fatigue. Fatigue levels were compared with a general pediatric Dutch population using linear regression, and quantifying the prevalence of “fatigued” (−2 < Standard deviations [SD] ≤ −1) and “severely fatigued” (SD ≤ −2) children. Secondly, we performed linear regression analyses to explore whether fatigue levels were independently associated with asthma attacks, comorbidities, medication, pulmonary function, symptom control, and asthma‐related quality of life (QoL).
Results
Severe pediatric asthma patients (n = 78, mean age 11.8 ± 3.1 years) reported significantly more fatigue than Dutch peers (n = 328, mean age 11.8 ± 3.2 years) mean difference in z‐score: −0.68; 95%CI −0.96, −0.40. In the severe asthma group, 28.2% scored as “fatigued” and 15.4% as “severely fatigued,” compared with 14.0% and 3.4% in the general population. In pediatric asthma patients, asthma‐related QoL (β = 0.77, p < .01, ΔR2 = .43), symptom control (β = 0.56, p < .01, ΔR2 = .24) and a dysfunctional breathing pattern (β = −0.36, p < .01, ΔR2 = .12) were most strongly associated with fatigue scores.
Conclusion
Fatigue is a common symptom in children with severe asthma and is associated with multiple clinical factors and patient‐reported outcomes. It should be considered as an important treatment target.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39450694</pmid><doi>10.1111/pai.14262</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-0414-3442</orcidid><orcidid>https://orcid.org/0000-0002-3305-3745</orcidid><orcidid>https://orcid.org/0000-0002-3996-1963</orcidid><orcidid>https://orcid.org/0000-0002-4579-4081</orcidid><orcidid>https://orcid.org/0009-0004-2381-9403</orcidid><orcidid>https://orcid.org/0000-0001-8995-3817</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Asthma Asthma - complications Asthma - diagnosis Asthma - epidemiology Child Children Cohort Studies Comorbidity Fatigue Fatigue - epidemiology Fatigue - etiology Female Humans Male Netherlands - epidemiology Patients patient‐reported outcome measures Pediatrics Prevalence Quality of Life Regression analysis Respiratory function Self Report severe asthma Severity of Illness Index Surveys and Questionnaires |
| title | Fatigue in severe pediatric asthma patients: Results of the PANDA study |
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