Abnormal functional lateralization and cooperation in bipolar disorder are associated with neurotransmitter and cellular profiles
Hemispheric lateralization and cooperation are essential for efficient brain function, and aberrations in both have been found in psychiatric disorders such as schizophrenia. This study investigated alterations in hemispheric lateralization and cooperation among patients with bipolar disorder (BD) a...
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| Veröffentlicht in: | Journal of affective disorders 2025-01, Vol.369, p.970-977 |
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| container_title | Journal of affective disorders |
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| creator | Huang, Tongqing Hua, Qiang Zhao, Xiya Tian, Weichao Cao, Hai Xu, Wenqiang Sun, Jinmei Zhang, Li Wang, Kai Ji, Gong-Jun |
| description | Hemispheric lateralization and cooperation are essential for efficient brain function, and aberrations in both have been found in psychiatric disorders such as schizophrenia. This study investigated alterations in hemispheric lateralization and cooperation among patients with bipolar disorder (BD) and associations with neurotransmitter and cell-type density distributions to identify potential molecular and cellular pathomechanisms.
Sixty-seven BD patients and 127 healthy controls (HCs) were examined by resting-state functional MRI (rs-fMRI). Whole-brain maps of the autonomy index (AI) and connectivity between functionally homotopic voxels (CFH) were constructed to reveal BD-specific changes in brain functional lateralization and interhemispheric cooperation, respectively. Spatial associations of regional AI and CFH abnormalities with neurotransmitter and cell-type density distributions were examined by correlation analyses.
Bipolar disorder patients exhibited higher AI values in left superior parietal gyrus, cerebellar right Crus I, and cerebellar right Crus II, and these regional abnormalities were associated with the relative densities (proportions) of oligodendrocyte precursor cells and microglia. Patients also exhibited lower CFH values in right inferior parietal gyrus, bilateral middle occipital gyrus, left postcentral gyrus, and bilateral cerebellar crus II, and these regional abnormalities were associated with the densities of serotonin 1A and dopamine D2 receptors, oligodendrocyte precursor cells, astrocytes, and neurons.
These findings indicate that abnormal functional lateralization and cooperation in BD with potential molecular and cellular basis.
•Bipolar disorder patients show abnormal brain lateralization and cooperation.•Increased functional lateralization in bipolar disorder is linked to cell-type density.•Decreased cooperation links to densities of neurotransmitter and cell types. |
| doi_str_mv | 10.1016/j.jad.2024.10.108 |
| format | Article |
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Sixty-seven BD patients and 127 healthy controls (HCs) were examined by resting-state functional MRI (rs-fMRI). Whole-brain maps of the autonomy index (AI) and connectivity between functionally homotopic voxels (CFH) were constructed to reveal BD-specific changes in brain functional lateralization and interhemispheric cooperation, respectively. Spatial associations of regional AI and CFH abnormalities with neurotransmitter and cell-type density distributions were examined by correlation analyses.
Bipolar disorder patients exhibited higher AI values in left superior parietal gyrus, cerebellar right Crus I, and cerebellar right Crus II, and these regional abnormalities were associated with the relative densities (proportions) of oligodendrocyte precursor cells and microglia. Patients also exhibited lower CFH values in right inferior parietal gyrus, bilateral middle occipital gyrus, left postcentral gyrus, and bilateral cerebellar crus II, and these regional abnormalities were associated with the densities of serotonin 1A and dopamine D2 receptors, oligodendrocyte precursor cells, astrocytes, and neurons.
These findings indicate that abnormal functional lateralization and cooperation in BD with potential molecular and cellular basis.
•Bipolar disorder patients show abnormal brain lateralization and cooperation.•Increased functional lateralization in bipolar disorder is linked to cell-type density.•Decreased cooperation links to densities of neurotransmitter and cell types.</description><identifier>ISSN: 0165-0327</identifier><identifier>ISSN: 1573-2517</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2024.10.108</identifier><identifier>PMID: 39447972</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Bipolar disorder ; Bipolar Disorder - diagnostic imaging ; Bipolar Disorder - physiopathology ; Brain - diagnostic imaging ; Brain - physiopathology ; Brain Mapping ; Case-Control Studies ; Cell-type abundances ; Female ; Functional Laterality - physiology ; Functional lateralization ; Humans ; Imaging ; Interhemispheric cooperation ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neurotransmitter Agents ; Neurotransmitters receptors/transporters ; Resting-state functional magnetic resonance</subject><ispartof>Journal of affective disorders, 2025-01, Vol.369, p.970-977</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c235t-b1842e69ea5cfd9f9a4055d80ece4d85e341462260a36abac01695624949a7f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165032724018032$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39447972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Tongqing</creatorcontrib><creatorcontrib>Hua, Qiang</creatorcontrib><creatorcontrib>Zhao, Xiya</creatorcontrib><creatorcontrib>Tian, Weichao</creatorcontrib><creatorcontrib>Cao, Hai</creatorcontrib><creatorcontrib>Xu, Wenqiang</creatorcontrib><creatorcontrib>Sun, Jinmei</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Wang, Kai</creatorcontrib><creatorcontrib>Ji, Gong-Jun</creatorcontrib><title>Abnormal functional lateralization and cooperation in bipolar disorder are associated with neurotransmitter and cellular profiles</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Hemispheric lateralization and cooperation are essential for efficient brain function, and aberrations in both have been found in psychiatric disorders such as schizophrenia. This study investigated alterations in hemispheric lateralization and cooperation among patients with bipolar disorder (BD) and associations with neurotransmitter and cell-type density distributions to identify potential molecular and cellular pathomechanisms.
Sixty-seven BD patients and 127 healthy controls (HCs) were examined by resting-state functional MRI (rs-fMRI). Whole-brain maps of the autonomy index (AI) and connectivity between functionally homotopic voxels (CFH) were constructed to reveal BD-specific changes in brain functional lateralization and interhemispheric cooperation, respectively. Spatial associations of regional AI and CFH abnormalities with neurotransmitter and cell-type density distributions were examined by correlation analyses.
Bipolar disorder patients exhibited higher AI values in left superior parietal gyrus, cerebellar right Crus I, and cerebellar right Crus II, and these regional abnormalities were associated with the relative densities (proportions) of oligodendrocyte precursor cells and microglia. Patients also exhibited lower CFH values in right inferior parietal gyrus, bilateral middle occipital gyrus, left postcentral gyrus, and bilateral cerebellar crus II, and these regional abnormalities were associated with the densities of serotonin 1A and dopamine D2 receptors, oligodendrocyte precursor cells, astrocytes, and neurons.
These findings indicate that abnormal functional lateralization and cooperation in BD with potential molecular and cellular basis.
•Bipolar disorder patients show abnormal brain lateralization and cooperation.•Increased functional lateralization in bipolar disorder is linked to cell-type density.•Decreased cooperation links to densities of neurotransmitter and cell types.</description><subject>Adult</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - diagnostic imaging</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiopathology</subject><subject>Brain Mapping</subject><subject>Case-Control Studies</subject><subject>Cell-type abundances</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Functional lateralization</subject><subject>Humans</subject><subject>Imaging</subject><subject>Interhemispheric cooperation</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurotransmitter Agents</subject><subject>Neurotransmitters receptors/transporters</subject><subject>Resting-state functional magnetic resonance</subject><issn>0165-0327</issn><issn>1573-2517</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAUhS1ERaeFB2CDvGSTwb9JLFZV1UKlSmzo2rqxb4RHiT3YCQh2vHmdTmHJyvbRd871PYS85WzPGW8_HPYH8HvBhNo_Sf0LsuO6k43QvHtJdpXRDZOiOycXpRwYY63p2CtyLo1SnenEjvy5GmLKM0x0XKNbQor1OsGCGabwGzaBQvTUpXSs2tM7RDqEY5ogUx9Kyh4zhYwUSkkuVK-nP8PyjUZcc1oyxDKHZdmgLQinad2sx5zGMGF5Tc5GmAq-eT4vycPtzdfrz839l09311f3jRNSL83AeyWwNQjajd6MBhTT2vcMHSrfa5SKq1aIloFsYQBXlze6FcooA90o5CV5f8qtg7-vWBY7h7L9BiKmtVjJBdNG91xWlJ9Ql1MpGUd7zGGG_MtyZrfm7cHW5u3W_Enqq-fdc_w6zOj_Of5WXYGPJwDrkj8CZltcwOjQh4xusT6F_8Q_AhSGlvU</recordid><startdate>20250115</startdate><enddate>20250115</enddate><creator>Huang, Tongqing</creator><creator>Hua, Qiang</creator><creator>Zhao, Xiya</creator><creator>Tian, Weichao</creator><creator>Cao, Hai</creator><creator>Xu, Wenqiang</creator><creator>Sun, Jinmei</creator><creator>Zhang, Li</creator><creator>Wang, Kai</creator><creator>Ji, Gong-Jun</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20250115</creationdate><title>Abnormal functional lateralization and cooperation in bipolar disorder are associated with neurotransmitter and cellular profiles</title><author>Huang, Tongqing ; Hua, Qiang ; Zhao, Xiya ; Tian, Weichao ; Cao, Hai ; Xu, Wenqiang ; Sun, Jinmei ; Zhang, Li ; Wang, Kai ; Ji, Gong-Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c235t-b1842e69ea5cfd9f9a4055d80ece4d85e341462260a36abac01695624949a7f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adult</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - diagnostic imaging</topic><topic>Bipolar Disorder - physiopathology</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - physiopathology</topic><topic>Brain Mapping</topic><topic>Case-Control Studies</topic><topic>Cell-type abundances</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Functional lateralization</topic><topic>Humans</topic><topic>Imaging</topic><topic>Interhemispheric cooperation</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurotransmitter Agents</topic><topic>Neurotransmitters receptors/transporters</topic><topic>Resting-state functional magnetic resonance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Tongqing</creatorcontrib><creatorcontrib>Hua, Qiang</creatorcontrib><creatorcontrib>Zhao, Xiya</creatorcontrib><creatorcontrib>Tian, Weichao</creatorcontrib><creatorcontrib>Cao, Hai</creatorcontrib><creatorcontrib>Xu, Wenqiang</creatorcontrib><creatorcontrib>Sun, Jinmei</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Wang, Kai</creatorcontrib><creatorcontrib>Ji, Gong-Jun</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Tongqing</au><au>Hua, Qiang</au><au>Zhao, Xiya</au><au>Tian, Weichao</au><au>Cao, Hai</au><au>Xu, Wenqiang</au><au>Sun, Jinmei</au><au>Zhang, Li</au><au>Wang, Kai</au><au>Ji, Gong-Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal functional lateralization and cooperation in bipolar disorder are associated with neurotransmitter and cellular profiles</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2025-01-15</date><risdate>2025</risdate><volume>369</volume><spage>970</spage><epage>977</epage><pages>970-977</pages><issn>0165-0327</issn><issn>1573-2517</issn><eissn>1573-2517</eissn><abstract>Hemispheric lateralization and cooperation are essential for efficient brain function, and aberrations in both have been found in psychiatric disorders such as schizophrenia. This study investigated alterations in hemispheric lateralization and cooperation among patients with bipolar disorder (BD) and associations with neurotransmitter and cell-type density distributions to identify potential molecular and cellular pathomechanisms.
Sixty-seven BD patients and 127 healthy controls (HCs) were examined by resting-state functional MRI (rs-fMRI). Whole-brain maps of the autonomy index (AI) and connectivity between functionally homotopic voxels (CFH) were constructed to reveal BD-specific changes in brain functional lateralization and interhemispheric cooperation, respectively. Spatial associations of regional AI and CFH abnormalities with neurotransmitter and cell-type density distributions were examined by correlation analyses.
Bipolar disorder patients exhibited higher AI values in left superior parietal gyrus, cerebellar right Crus I, and cerebellar right Crus II, and these regional abnormalities were associated with the relative densities (proportions) of oligodendrocyte precursor cells and microglia. Patients also exhibited lower CFH values in right inferior parietal gyrus, bilateral middle occipital gyrus, left postcentral gyrus, and bilateral cerebellar crus II, and these regional abnormalities were associated with the densities of serotonin 1A and dopamine D2 receptors, oligodendrocyte precursor cells, astrocytes, and neurons.
These findings indicate that abnormal functional lateralization and cooperation in BD with potential molecular and cellular basis.
•Bipolar disorder patients show abnormal brain lateralization and cooperation.•Increased functional lateralization in bipolar disorder is linked to cell-type density.•Decreased cooperation links to densities of neurotransmitter and cell types.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39447972</pmid><doi>10.1016/j.jad.2024.10.108</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Bipolar disorder Bipolar Disorder - diagnostic imaging Bipolar Disorder - physiopathology Brain - diagnostic imaging Brain - physiopathology Brain Mapping Case-Control Studies Cell-type abundances Female Functional Laterality - physiology Functional lateralization Humans Imaging Interhemispheric cooperation Magnetic Resonance Imaging Male Middle Aged Neurotransmitter Agents Neurotransmitters receptors/transporters Resting-state functional magnetic resonance |
| title | Abnormal functional lateralization and cooperation in bipolar disorder are associated with neurotransmitter and cellular profiles |
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