Pancreatic fat infiltration is associated with risk of vertebral fracture in older patients with type 2 diabetes: A longitudinal multicenter study
•The association between pancreatic fat and vertebral fracture in patients with type 2 diabetes is unknown.•Pancreatic CT attenuation or P/S ratio is associated factor for vertebral fracture in patients with type 2 diabetes.•Addition of pancreatic attenuation or P/S ratio improved the performance of...
Gespeichert in:
| Veröffentlicht in: | Diabetes research and clinical practice 2024-11, Vol.217, p.111904, Article 111904 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | 111904 |
| container_title | Diabetes research and clinical practice |
| container_volume | 217 |
| creator | Wang, Jiangchuan Wei, Zicheng Wang, Yu Zhang, Dingzhe Wang, Miaomiao Chen, Xin Xia, Peng Wang, Jianhua Xie, Chao Chen, Xiao |
| description | •The association between pancreatic fat and vertebral fracture in patients with type 2 diabetes is unknown.•Pancreatic CT attenuation or P/S ratio is associated factor for vertebral fracture in patients with type 2 diabetes.•Addition of pancreatic attenuation or P/S ratio improved the performance of bone-based predictive model.
Patients with type 2diabetesmellitus (T2DM) have high fracture risk. This study explored the associations between pancreatic computed tomography (CT) attenuation, a marker of pancreatic fat, and risk of vertebral fracture in T2DM patients.
A total of 1486 T2DM patients who aged 50 years and older and without preexisting vertebral fractures during 2019–2023 at our institutions were followed up untilJanuary 2024. CT attenuation of the pancreas, bone and spleen were measured. Pancreatic attenuation/spleen attenuation ratio (P/S) was calculated. Vertebral fractures were evaluated on spine CT images according to Genant’s semiquantitative scoring system.
A total of 135 cases of vertebral fracture were identified during 26 months of follow-up and 270 patients without vertebral fracture were matched. Pancreatic CT attenuation and the P/S ratio were negatively associated with the risk of vertebral fracture (adjusted hazard ratio (aHR) = 0.97, 95 %confidence interval (CI): 0.96–0.99; aHR = 0.26, 95 %CI: 0.12–0.58). Addition of pancreatic attenuation or P/S ratio improved the performance of bone attenuation-based model (area under the curve = 0.72–0.763 vs 0.63–0.728).
Pancreatic fat infiltration is an associated factor for vertebral fracture in T2DM patients. Addition of pancreatic fat infiltration improved the predictive performance of the bone-based model. |
| doi_str_mv | 10.1016/j.diabres.2024.111904 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3120595020</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168822724008143</els_id><sourcerecordid>3120595020</sourcerecordid><originalsourceid>FETCH-LOGICAL-c243t-b3a79680acf5d82e7279aa1789fcfccd77d811265e63def0d307047354cde6c13</originalsourceid><addsrcrecordid>eNqFkctOGzEUhq0KVFLaR6Dykk1SX2bGM90gFEFBQoIFXVuOfVycTsbBxwPKa_DEdTppt6x80ff5HJ-fkDPOFpzx5tt64YJZJcCFYKJacM47Vn0gM94qMW-FUEdkVrj27_6EfEJcM8YaWdUfyYnsqko1qp2Rtwcz2AQmB0u9yTQMPvQ5lXMcaEBqEKMNJoOjryE_0RTwN42evkDKsEqmpz4Zm8cERaWxd5DottgwZJyMvNsCFXTfLWTA7_SS9nH4FfLowlD8zdiX4oUvJpbL3Wdy7E2P8OWwnpKf11ePy5v53f2P2-Xl3dyKSub5ShrVNS0z1teuFaCE6ozhqu289dY6pVzLuWhqaKQDz5xkilVK1pV10FguT8n59O42xecRMOtNQAt9bwaII2rJBau7mglW0HpCbYqICbzeprAxaac50_s49Fof4tD7OPQUR_G-HkqMqw24_9a_-RfgYgKgfPQlQNJoy-wsuJDAZu1ieKfEHzw5oXE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3120595020</pqid></control><display><type>article</type><title>Pancreatic fat infiltration is associated with risk of vertebral fracture in older patients with type 2 diabetes: A longitudinal multicenter study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Wang, Jiangchuan ; Wei, Zicheng ; Wang, Yu ; Zhang, Dingzhe ; Wang, Miaomiao ; Chen, Xin ; Xia, Peng ; Wang, Jianhua ; Xie, Chao ; Chen, Xiao</creator><creatorcontrib>Wang, Jiangchuan ; Wei, Zicheng ; Wang, Yu ; Zhang, Dingzhe ; Wang, Miaomiao ; Chen, Xin ; Xia, Peng ; Wang, Jianhua ; Xie, Chao ; Chen, Xiao</creatorcontrib><description>•The association between pancreatic fat and vertebral fracture in patients with type 2 diabetes is unknown.•Pancreatic CT attenuation or P/S ratio is associated factor for vertebral fracture in patients with type 2 diabetes.•Addition of pancreatic attenuation or P/S ratio improved the performance of bone-based predictive model.
Patients with type 2diabetesmellitus (T2DM) have high fracture risk. This study explored the associations between pancreatic computed tomography (CT) attenuation, a marker of pancreatic fat, and risk of vertebral fracture in T2DM patients.
A total of 1486 T2DM patients who aged 50 years and older and without preexisting vertebral fractures during 2019–2023 at our institutions were followed up untilJanuary 2024. CT attenuation of the pancreas, bone and spleen were measured. Pancreatic attenuation/spleen attenuation ratio (P/S) was calculated. Vertebral fractures were evaluated on spine CT images according to Genant’s semiquantitative scoring system.
A total of 135 cases of vertebral fracture were identified during 26 months of follow-up and 270 patients without vertebral fracture were matched. Pancreatic CT attenuation and the P/S ratio were negatively associated with the risk of vertebral fracture (adjusted hazard ratio (aHR) = 0.97, 95 %confidence interval (CI): 0.96–0.99; aHR = 0.26, 95 %CI: 0.12–0.58). Addition of pancreatic attenuation or P/S ratio improved the performance of bone attenuation-based model (area under the curve = 0.72–0.763 vs 0.63–0.728).
Pancreatic fat infiltration is an associated factor for vertebral fracture in T2DM patients. Addition of pancreatic fat infiltration improved the predictive performance of the bone-based model.</description><identifier>ISSN: 0168-8227</identifier><identifier>ISSN: 1872-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2024.111904</identifier><identifier>PMID: 39447678</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adipose Tissue - diagnostic imaging ; Adipose Tissue - pathology ; Aged ; Diabetes Mellitus, Type 2 - complications ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Pancreas - diagnostic imaging ; Pancreas - pathology ; Pancreatic attenuation ; Risk Factors ; Spinal Fractures - diagnostic imaging ; Spinal Fractures - epidemiology ; Spinal Fractures - etiology ; Tomography, X-Ray Computed ; Type 2 diabetes ; Vertebral fracture</subject><ispartof>Diabetes research and clinical practice, 2024-11, Vol.217, p.111904, Article 111904</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c243t-b3a79680acf5d82e7279aa1789fcfccd77d811265e63def0d307047354cde6c13</cites><orcidid>0000-0002-8354-9087</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168822724008143$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39447678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jiangchuan</creatorcontrib><creatorcontrib>Wei, Zicheng</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Zhang, Dingzhe</creatorcontrib><creatorcontrib>Wang, Miaomiao</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Xia, Peng</creatorcontrib><creatorcontrib>Wang, Jianhua</creatorcontrib><creatorcontrib>Xie, Chao</creatorcontrib><creatorcontrib>Chen, Xiao</creatorcontrib><title>Pancreatic fat infiltration is associated with risk of vertebral fracture in older patients with type 2 diabetes: A longitudinal multicenter study</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>•The association between pancreatic fat and vertebral fracture in patients with type 2 diabetes is unknown.•Pancreatic CT attenuation or P/S ratio is associated factor for vertebral fracture in patients with type 2 diabetes.•Addition of pancreatic attenuation or P/S ratio improved the performance of bone-based predictive model.
Patients with type 2diabetesmellitus (T2DM) have high fracture risk. This study explored the associations between pancreatic computed tomography (CT) attenuation, a marker of pancreatic fat, and risk of vertebral fracture in T2DM patients.
A total of 1486 T2DM patients who aged 50 years and older and without preexisting vertebral fractures during 2019–2023 at our institutions were followed up untilJanuary 2024. CT attenuation of the pancreas, bone and spleen were measured. Pancreatic attenuation/spleen attenuation ratio (P/S) was calculated. Vertebral fractures were evaluated on spine CT images according to Genant’s semiquantitative scoring system.
A total of 135 cases of vertebral fracture were identified during 26 months of follow-up and 270 patients without vertebral fracture were matched. Pancreatic CT attenuation and the P/S ratio were negatively associated with the risk of vertebral fracture (adjusted hazard ratio (aHR) = 0.97, 95 %confidence interval (CI): 0.96–0.99; aHR = 0.26, 95 %CI: 0.12–0.58). Addition of pancreatic attenuation or P/S ratio improved the performance of bone attenuation-based model (area under the curve = 0.72–0.763 vs 0.63–0.728).
Pancreatic fat infiltration is an associated factor for vertebral fracture in T2DM patients. Addition of pancreatic fat infiltration improved the predictive performance of the bone-based model.</description><subject>Adipose Tissue - diagnostic imaging</subject><subject>Adipose Tissue - pathology</subject><subject>Aged</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Female</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreas - diagnostic imaging</subject><subject>Pancreas - pathology</subject><subject>Pancreatic attenuation</subject><subject>Risk Factors</subject><subject>Spinal Fractures - diagnostic imaging</subject><subject>Spinal Fractures - epidemiology</subject><subject>Spinal Fractures - etiology</subject><subject>Tomography, X-Ray Computed</subject><subject>Type 2 diabetes</subject><subject>Vertebral fracture</subject><issn>0168-8227</issn><issn>1872-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctOGzEUhq0KVFLaR6Dykk1SX2bGM90gFEFBQoIFXVuOfVycTsbBxwPKa_DEdTppt6x80ff5HJ-fkDPOFpzx5tt64YJZJcCFYKJacM47Vn0gM94qMW-FUEdkVrj27_6EfEJcM8YaWdUfyYnsqko1qp2Rtwcz2AQmB0u9yTQMPvQ5lXMcaEBqEKMNJoOjryE_0RTwN42evkDKsEqmpz4Zm8cERaWxd5DottgwZJyMvNsCFXTfLWTA7_SS9nH4FfLowlD8zdiX4oUvJpbL3Wdy7E2P8OWwnpKf11ePy5v53f2P2-Xl3dyKSub5ShrVNS0z1teuFaCE6ozhqu289dY6pVzLuWhqaKQDz5xkilVK1pV10FguT8n59O42xecRMOtNQAt9bwaII2rJBau7mglW0HpCbYqICbzeprAxaac50_s49Fof4tD7OPQUR_G-HkqMqw24_9a_-RfgYgKgfPQlQNJoy-wsuJDAZu1ieKfEHzw5oXE</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Wang, Jiangchuan</creator><creator>Wei, Zicheng</creator><creator>Wang, Yu</creator><creator>Zhang, Dingzhe</creator><creator>Wang, Miaomiao</creator><creator>Chen, Xin</creator><creator>Xia, Peng</creator><creator>Wang, Jianhua</creator><creator>Xie, Chao</creator><creator>Chen, Xiao</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8354-9087</orcidid></search><sort><creationdate>202411</creationdate><title>Pancreatic fat infiltration is associated with risk of vertebral fracture in older patients with type 2 diabetes: A longitudinal multicenter study</title><author>Wang, Jiangchuan ; Wei, Zicheng ; Wang, Yu ; Zhang, Dingzhe ; Wang, Miaomiao ; Chen, Xin ; Xia, Peng ; Wang, Jianhua ; Xie, Chao ; Chen, Xiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c243t-b3a79680acf5d82e7279aa1789fcfccd77d811265e63def0d307047354cde6c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adipose Tissue - diagnostic imaging</topic><topic>Adipose Tissue - pathology</topic><topic>Aged</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Female</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pancreas - diagnostic imaging</topic><topic>Pancreas - pathology</topic><topic>Pancreatic attenuation</topic><topic>Risk Factors</topic><topic>Spinal Fractures - diagnostic imaging</topic><topic>Spinal Fractures - epidemiology</topic><topic>Spinal Fractures - etiology</topic><topic>Tomography, X-Ray Computed</topic><topic>Type 2 diabetes</topic><topic>Vertebral fracture</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jiangchuan</creatorcontrib><creatorcontrib>Wei, Zicheng</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Zhang, Dingzhe</creatorcontrib><creatorcontrib>Wang, Miaomiao</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Xia, Peng</creatorcontrib><creatorcontrib>Wang, Jianhua</creatorcontrib><creatorcontrib>Xie, Chao</creatorcontrib><creatorcontrib>Chen, Xiao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jiangchuan</au><au>Wei, Zicheng</au><au>Wang, Yu</au><au>Zhang, Dingzhe</au><au>Wang, Miaomiao</au><au>Chen, Xin</au><au>Xia, Peng</au><au>Wang, Jianhua</au><au>Xie, Chao</au><au>Chen, Xiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pancreatic fat infiltration is associated with risk of vertebral fracture in older patients with type 2 diabetes: A longitudinal multicenter study</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2024-11</date><risdate>2024</risdate><volume>217</volume><spage>111904</spage><pages>111904-</pages><artnum>111904</artnum><issn>0168-8227</issn><issn>1872-8227</issn><eissn>1872-8227</eissn><abstract>•The association between pancreatic fat and vertebral fracture in patients with type 2 diabetes is unknown.•Pancreatic CT attenuation or P/S ratio is associated factor for vertebral fracture in patients with type 2 diabetes.•Addition of pancreatic attenuation or P/S ratio improved the performance of bone-based predictive model.
Patients with type 2diabetesmellitus (T2DM) have high fracture risk. This study explored the associations between pancreatic computed tomography (CT) attenuation, a marker of pancreatic fat, and risk of vertebral fracture in T2DM patients.
A total of 1486 T2DM patients who aged 50 years and older and without preexisting vertebral fractures during 2019–2023 at our institutions were followed up untilJanuary 2024. CT attenuation of the pancreas, bone and spleen were measured. Pancreatic attenuation/spleen attenuation ratio (P/S) was calculated. Vertebral fractures were evaluated on spine CT images according to Genant’s semiquantitative scoring system.
A total of 135 cases of vertebral fracture were identified during 26 months of follow-up and 270 patients without vertebral fracture were matched. Pancreatic CT attenuation and the P/S ratio were negatively associated with the risk of vertebral fracture (adjusted hazard ratio (aHR) = 0.97, 95 %confidence interval (CI): 0.96–0.99; aHR = 0.26, 95 %CI: 0.12–0.58). Addition of pancreatic attenuation or P/S ratio improved the performance of bone attenuation-based model (area under the curve = 0.72–0.763 vs 0.63–0.728).
Pancreatic fat infiltration is an associated factor for vertebral fracture in T2DM patients. Addition of pancreatic fat infiltration improved the predictive performance of the bone-based model.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>39447678</pmid><doi>10.1016/j.diabres.2024.111904</doi><orcidid>https://orcid.org/0000-0002-8354-9087</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-8227 |
| ispartof | Diabetes research and clinical practice, 2024-11, Vol.217, p.111904, Article 111904 |
| issn | 0168-8227 1872-8227 1872-8227 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3120595020 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adipose Tissue - diagnostic imaging Adipose Tissue - pathology Aged Diabetes Mellitus, Type 2 - complications Female Humans Longitudinal Studies Male Middle Aged Pancreas - diagnostic imaging Pancreas - pathology Pancreatic attenuation Risk Factors Spinal Fractures - diagnostic imaging Spinal Fractures - epidemiology Spinal Fractures - etiology Tomography, X-Ray Computed Type 2 diabetes Vertebral fracture |
| title | Pancreatic fat infiltration is associated with risk of vertebral fracture in older patients with type 2 diabetes: A longitudinal multicenter study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T19%3A49%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pancreatic%20fat%20infiltration%20is%20associated%20with%20risk%20of%20vertebral%20fracture%20in%20older%20patients%20with%20type%202%20diabetes:%20A%20longitudinal%20multicenter%20study&rft.jtitle=Diabetes%20research%20and%20clinical%20practice&rft.au=Wang,%20Jiangchuan&rft.date=2024-11&rft.volume=217&rft.spage=111904&rft.pages=111904-&rft.artnum=111904&rft.issn=0168-8227&rft.eissn=1872-8227&rft_id=info:doi/10.1016/j.diabres.2024.111904&rft_dat=%3Cproquest_cross%3E3120595020%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3120595020&rft_id=info:pmid/39447678&rft_els_id=S0168822724008143&rfr_iscdi=true |