Discovery of Potent and Selective Blockers Targeting the Epilepsy-Associated KNa1.1 Channel

Gain-of-function (GOF) mutations of the sodium-activated potassium channel KNa1.1 (Slack, Slo2.2, or KCa4.1) induce severe, drug-resistant forms of epilepsy in infants and children. Although quinidine has shown promise in treating KCNT1-related epilepsies compared to other drugs, its limited efficac...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-11, Vol.67 (21), p.19519-19545
Hauptverfasser:	Zheng, Ruqiu, Li, Zhongtang, Wang, Qiufeng, Liu, Shiqi, Liu, Ningfeng, Li, Yiyan, Zhu, Guiwang, Liu, Zhenming, Huang, Zhuo, Zhang, Liangren
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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