Development of Radiolabeled Probes with Improved Imaging Contrast by Releasing Urinary Excretable Radiolabeled Compounds from Thermosensitive Liposomes in the Blood

In this study, thermosensitive liposomes (TSLs) encapsulating urinary excretable radiolabeled compounds were developed. We considered that the release of the radiolabeled compounds from the TSLs in the blood by heating the blood in peripheral tissues can achieve rapid clearance of radioactivity, res...

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Veröffentlicht in:	Molecular pharmaceutics 2024-11, Vol.21 (11), p.5728-5735
Hauptverfasser:	Munekane, Masayuki, Ozaki, Miki, Mitani, Yuri, Sakaida, Natsuki, Sano, Kohei, Yamasaki, Toshihide, Mukai, Takahiro, Mishiro, Kenji, Fuchigami, Takeshi, Ogawa, Kazuma
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Dipalmitoylphosphatidylcholine - chemistry 1,2-Dipalmitoylphosphatidylcholine - pharmacokinetics Animals Contrast Media - chemistry Contrast Media - pharmacokinetics Female Humans Indium Radioisotopes Liposomes - chemistry Mice Mice, Inbred BALB C Pentetic Acid - chemistry Pentetic Acid - pharmacokinetics Radiopharmaceuticals - chemistry Radiopharmaceuticals - pharmacokinetics Radiopharmaceuticals - urine Tissue Distribution
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