Differentiation fate of a stem-like CD4 T cell controls immunity to cancer

The T cell response to cancer controls disease progression and response to immunotherapy 1 , 2 – 3 . Despite extensive knowledge regarding CD8 T cells, how CD4 T cells contribute to this process is less well understood. Here we identified a population of PD1 + TCF1 + CD4 T cells with stem-like prope...

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Veröffentlicht in:	Nature (London) 2024-12, Vol.636 (8041), p.224-232
Hauptverfasser:	Cardenas, Maria A., Prokhnevska, Nataliya, Sobierajska, Ewelina, Gregorova, Petra, Medina, Christopher B., Valanparambil, Rajesh M., Greenwald, Rachel, DelBalzo, Luke, Bilen, Mehmet Asim, Joshi, Shreyas S., Narayan, Vikram M., Master, Viraj A., Sanda, Martin G., Kissick, Haydn T.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/109 13/21 13/31 38/91 42/44 631/250/1619 631/250/580 Animals CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cell Differentiation Cell Self Renewal Female Hepatocyte Nuclear Factor 1-alpha - metabolism Humanities and Social Sciences Humans Immunotherapy Interferon-gamma - immunology Interferon-gamma - metabolism Kidney Neoplasms - immunology Kidney Neoplasms - pathology Kidney Neoplasms - therapy Lymph Nodes - cytology Lymph Nodes - immunology Male Mice Mice, Inbred C57BL multidisciplinary Science Science (multidisciplinary) Stem Cells - cytology Stem Cells - immunology T-Box Domain Proteins - metabolism T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology Th1 Cells - cytology Th1 Cells - immunology
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