Sodium bicarbonate potentiates the antitumor effects of Olaparib in ovarian cancer via cGMP/PKG-mediated ROS scavenging and M1 macrophage transformation

The high metabolic requirements of cancer cells result in excess accumulation of H+ in the tumor microenvironment. Therefore, the extracellular pH of solid tumors is acidic, whereas the pH of normal tissues is more alkaline. The acidic tumor environment is correlated with tumor metastasis, immune es...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2024-11, Vol.180, p.117509, Article 117509
Hauptverfasser:	Li, Xiao, Sun, Yaoqi, Guo, Jing, Cheng, Yujie, Lu, Wei, Yang, Weihong, Wang, Lian, Cheng, Zhongping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Movement - drug effects Cyclic GMP - metabolism Cyclic GMP-Dependent Protein Kinases - metabolism Drug Synergism Female Humans Macrophage Macrophages - drug effects Macrophages - metabolism Mice Mice, Inbred BALB C Mice, Nude Olaparib Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Phthalazines - pharmacology Piperazines - pharmacology Reactive oxygen species Reactive Oxygen Species - metabolism Signal Transduction - drug effects Sodium bicarbonate Sodium Bicarbonate - pharmacology Tumor Microenvironment - drug effects
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