The Role of Global Longitudinal Strain in Predicting Left Ventricular Reverse Remodeling After Mitral Valve Replacement Surgery in Patients With Primary Mitral Regurgitation
ABSTRACT Objectives This study aimed to identify the utility of global longitudinal strain (GLS) as a reliable parameter that can accurately forecast left ventricle reverse remodeling (LVRR) in patients undergoing valve replacement surgery for severe chronic primary mitral regurgitation (MR), thereb...
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| Veröffentlicht in: | Echocardiography (Mount Kisco, N.Y.) N.Y.), 2024-11, Vol.41 (11), p.e15950-n/a |
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| container_title | Echocardiography (Mount Kisco, N.Y.) |
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| creator | Natalino, Liem Audi Marsam, Real Kusumanjaya Dinarti, Lucia Kris Mumpuni, Hasanah Anggrahini, Dyah Wulan |
| description | ABSTRACT
Objectives
This study aimed to identify the utility of global longitudinal strain (GLS) as a reliable parameter that can accurately forecast left ventricle reverse remodeling (LVRR) in patients undergoing valve replacement surgery for severe chronic primary mitral regurgitation (MR), thereby aiding in assessing mortality and morbidity risk.
Methods
This retrospective observational study involved severe primary MR patients who underwent valve replacement surgery between 2018 and 2023. Pre‐ and postsurgery echocardiography data were collected, with GLS measurements utilized to assess left ventricular function. Various echocardiography parameters, including MR severity and LV dimensions, were analyzed. Bivariate and multivariate analyses were performed to explore relationships between GLS and LVRR.
Results
This study enrolled 103 patients (54.4% male; mean age 45.4 ± 13.6 years). Statistical analyses revealed GLS to be an independent predictor of LVRR, with a threshold of −16.25% showing 89% sensitivity and 50% specificity. Each 1% increase in GLS corresponded to a 1.14‐fold (odds ratio [OR]: 1.14; 95% confidence interval [CI]: 1.01–1.31; p |
| doi_str_mv | 10.1111/echo.15950 |
| format | Article |
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Objectives
This study aimed to identify the utility of global longitudinal strain (GLS) as a reliable parameter that can accurately forecast left ventricle reverse remodeling (LVRR) in patients undergoing valve replacement surgery for severe chronic primary mitral regurgitation (MR), thereby aiding in assessing mortality and morbidity risk.
Methods
This retrospective observational study involved severe primary MR patients who underwent valve replacement surgery between 2018 and 2023. Pre‐ and postsurgery echocardiography data were collected, with GLS measurements utilized to assess left ventricular function. Various echocardiography parameters, including MR severity and LV dimensions, were analyzed. Bivariate and multivariate analyses were performed to explore relationships between GLS and LVRR.
Results
This study enrolled 103 patients (54.4% male; mean age 45.4 ± 13.6 years). Statistical analyses revealed GLS to be an independent predictor of LVRR, with a threshold of −16.25% showing 89% sensitivity and 50% specificity. Each 1% increase in GLS corresponded to a 1.14‐fold (odds ratio [OR]: 1.14; 95% confidence interval [CI]: 1.01–1.31; p < 0.05) increased likelihood of LVRR.
Conclusion
These findings highlight GLS's potential as a prognostic marker for postsurgical outcomes in severe MR patients.
Each 1% increase in GLS corresponded to a 1.14‐fold increased likelihood of LVRR.</description><identifier>ISSN: 0742-2822</identifier><identifier>ISSN: 1540-8175</identifier><identifier>EISSN: 1540-8175</identifier><identifier>DOI: 10.1111/echo.15950</identifier><identifier>PMID: 39440905</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; echocardiography ; Echocardiography - methods ; Female ; Global Longitudinal Strain ; Heart Valve Prosthesis Implantation - methods ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - physiopathology ; Humans ; Male ; Middle Aged ; Mitral Valve - diagnostic imaging ; Mitral Valve - physiopathology ; Mitral Valve - surgery ; mitral valve insufficiency ; Mitral Valve Insufficiency - diagnostic imaging ; Mitral Valve Insufficiency - physiopathology ; Mitral Valve Insufficiency - surgery ; Predictive Value of Tests ; Retrospective Studies ; Ventricular Function, Left - physiology ; ventricular remodeling ; Ventricular Remodeling - physiology</subject><ispartof>Echocardiography (Mount Kisco, N.Y.), 2024-11, Vol.41 (11), p.e15950-n/a</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2180-69efc42300dde38c3ac9e597cf25589a7215bc5803255b5d7b783456226e8cc63</cites><orcidid>0009-0008-6405-6149 ; 0000-0002-4011-2184</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fecho.15950$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fecho.15950$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39440905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Natalino, Liem Audi</creatorcontrib><creatorcontrib>Marsam, Real Kusumanjaya</creatorcontrib><creatorcontrib>Dinarti, Lucia Kris</creatorcontrib><creatorcontrib>Mumpuni, Hasanah</creatorcontrib><creatorcontrib>Anggrahini, Dyah Wulan</creatorcontrib><title>The Role of Global Longitudinal Strain in Predicting Left Ventricular Reverse Remodeling After Mitral Valve Replacement Surgery in Patients With Primary Mitral Regurgitation</title><title>Echocardiography (Mount Kisco, N.Y.)</title><addtitle>Echocardiography</addtitle><description>ABSTRACT
Objectives
This study aimed to identify the utility of global longitudinal strain (GLS) as a reliable parameter that can accurately forecast left ventricle reverse remodeling (LVRR) in patients undergoing valve replacement surgery for severe chronic primary mitral regurgitation (MR), thereby aiding in assessing mortality and morbidity risk.
Methods
This retrospective observational study involved severe primary MR patients who underwent valve replacement surgery between 2018 and 2023. Pre‐ and postsurgery echocardiography data were collected, with GLS measurements utilized to assess left ventricular function. Various echocardiography parameters, including MR severity and LV dimensions, were analyzed. Bivariate and multivariate analyses were performed to explore relationships between GLS and LVRR.
Results
This study enrolled 103 patients (54.4% male; mean age 45.4 ± 13.6 years). Statistical analyses revealed GLS to be an independent predictor of LVRR, with a threshold of −16.25% showing 89% sensitivity and 50% specificity. Each 1% increase in GLS corresponded to a 1.14‐fold (odds ratio [OR]: 1.14; 95% confidence interval [CI]: 1.01–1.31; p < 0.05) increased likelihood of LVRR.
Conclusion
These findings highlight GLS's potential as a prognostic marker for postsurgical outcomes in severe MR patients.
Each 1% increase in GLS corresponded to a 1.14‐fold increased likelihood of LVRR.</description><subject>Adult</subject><subject>echocardiography</subject><subject>Echocardiography - methods</subject><subject>Female</subject><subject>Global Longitudinal Strain</subject><subject>Heart Valve Prosthesis Implantation - methods</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mitral Valve - diagnostic imaging</subject><subject>Mitral Valve - physiopathology</subject><subject>Mitral Valve - surgery</subject><subject>mitral valve insufficiency</subject><subject>Mitral Valve Insufficiency - diagnostic imaging</subject><subject>Mitral Valve Insufficiency - physiopathology</subject><subject>Mitral Valve Insufficiency - surgery</subject><subject>Predictive Value of Tests</subject><subject>Retrospective Studies</subject><subject>Ventricular Function, Left - physiology</subject><subject>ventricular remodeling</subject><subject>Ventricular Remodeling - physiology</subject><issn>0742-2822</issn><issn>1540-8175</issn><issn>1540-8175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctOxCAUhonR6HjZ-ACGpTGpAi1DuzQTb8kYzXhbNpSezmBoGYFqfCjfUcaOLiUk5HC-8xHyI3RIySmN6wzUwp5SXnCygUaUZyTJqeCbaERExhKWM7aDdr1_JYQISrNttJMWWUYKwkfo63EBeGYNYNvgK2MrafDUdnMd-lp3sXgITuoOx33voNYq6G6Op9AE_AxdcFr1Rjo8g3dwPpqgtTWYFXPeBHD4Vsd5g5-leV91l0YqaOMgfujdHNznj1gGHa88ftFhEZ_RrYyN9eQM5pHUITK220dbjTQeDtbnHnq6vHicXCfTu6ubyfk0UYzmJBkX0KiMpYTUNaS5SqUqgBdCNYzzvJCCUV4pnpM01hWvRSXyNONjxsaQKzVO99Dx4F06-9aDD2WrvQJjZAe292VKaSFYRpmI6MmAKme9d9CUy-EDJSXlKp5yFU_5E0-Ej9bevmqh_kN_84gAHYAPbeDzH1V5Mbm-G6Tf2_GdDw</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Natalino, Liem Audi</creator><creator>Marsam, Real Kusumanjaya</creator><creator>Dinarti, Lucia Kris</creator><creator>Mumpuni, Hasanah</creator><creator>Anggrahini, Dyah Wulan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0008-6405-6149</orcidid><orcidid>https://orcid.org/0000-0002-4011-2184</orcidid></search><sort><creationdate>202411</creationdate><title>The Role of Global Longitudinal Strain in Predicting Left Ventricular Reverse Remodeling After Mitral Valve Replacement Surgery in Patients With Primary Mitral Regurgitation</title><author>Natalino, Liem Audi ; Marsam, Real Kusumanjaya ; Dinarti, Lucia Kris ; Mumpuni, Hasanah ; Anggrahini, Dyah Wulan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2180-69efc42300dde38c3ac9e597cf25589a7215bc5803255b5d7b783456226e8cc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>echocardiography</topic><topic>Echocardiography - methods</topic><topic>Female</topic><topic>Global Longitudinal Strain</topic><topic>Heart Valve Prosthesis Implantation - methods</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mitral Valve - diagnostic imaging</topic><topic>Mitral Valve - physiopathology</topic><topic>Mitral Valve - surgery</topic><topic>mitral valve insufficiency</topic><topic>Mitral Valve Insufficiency - diagnostic imaging</topic><topic>Mitral Valve Insufficiency - physiopathology</topic><topic>Mitral Valve Insufficiency - surgery</topic><topic>Predictive Value of Tests</topic><topic>Retrospective Studies</topic><topic>Ventricular Function, Left - physiology</topic><topic>ventricular remodeling</topic><topic>Ventricular Remodeling - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Natalino, Liem Audi</creatorcontrib><creatorcontrib>Marsam, Real Kusumanjaya</creatorcontrib><creatorcontrib>Dinarti, Lucia Kris</creatorcontrib><creatorcontrib>Mumpuni, Hasanah</creatorcontrib><creatorcontrib>Anggrahini, Dyah Wulan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Echocardiography (Mount Kisco, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Natalino, Liem Audi</au><au>Marsam, Real Kusumanjaya</au><au>Dinarti, Lucia Kris</au><au>Mumpuni, Hasanah</au><au>Anggrahini, Dyah Wulan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Global Longitudinal Strain in Predicting Left Ventricular Reverse Remodeling After Mitral Valve Replacement Surgery in Patients With Primary Mitral Regurgitation</atitle><jtitle>Echocardiography (Mount Kisco, N.Y.)</jtitle><addtitle>Echocardiography</addtitle><date>2024-11</date><risdate>2024</risdate><volume>41</volume><issue>11</issue><spage>e15950</spage><epage>n/a</epage><pages>e15950-n/a</pages><issn>0742-2822</issn><issn>1540-8175</issn><eissn>1540-8175</eissn><abstract>ABSTRACT
Objectives
This study aimed to identify the utility of global longitudinal strain (GLS) as a reliable parameter that can accurately forecast left ventricle reverse remodeling (LVRR) in patients undergoing valve replacement surgery for severe chronic primary mitral regurgitation (MR), thereby aiding in assessing mortality and morbidity risk.
Methods
This retrospective observational study involved severe primary MR patients who underwent valve replacement surgery between 2018 and 2023. Pre‐ and postsurgery echocardiography data were collected, with GLS measurements utilized to assess left ventricular function. Various echocardiography parameters, including MR severity and LV dimensions, were analyzed. Bivariate and multivariate analyses were performed to explore relationships between GLS and LVRR.
Results
This study enrolled 103 patients (54.4% male; mean age 45.4 ± 13.6 years). Statistical analyses revealed GLS to be an independent predictor of LVRR, with a threshold of −16.25% showing 89% sensitivity and 50% specificity. Each 1% increase in GLS corresponded to a 1.14‐fold (odds ratio [OR]: 1.14; 95% confidence interval [CI]: 1.01–1.31; p < 0.05) increased likelihood of LVRR.
Conclusion
These findings highlight GLS's potential as a prognostic marker for postsurgical outcomes in severe MR patients.
Each 1% increase in GLS corresponded to a 1.14‐fold increased likelihood of LVRR.</abstract><cop>United States</cop><pmid>39440905</pmid><doi>10.1111/echo.15950</doi><tpages>8</tpages><orcidid>https://orcid.org/0009-0008-6405-6149</orcidid><orcidid>https://orcid.org/0000-0002-4011-2184</orcidid></addata></record> |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Adult echocardiography Echocardiography - methods Female Global Longitudinal Strain Heart Valve Prosthesis Implantation - methods Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Humans Male Middle Aged Mitral Valve - diagnostic imaging Mitral Valve - physiopathology Mitral Valve - surgery mitral valve insufficiency Mitral Valve Insufficiency - diagnostic imaging Mitral Valve Insufficiency - physiopathology Mitral Valve Insufficiency - surgery Predictive Value of Tests Retrospective Studies Ventricular Function, Left - physiology ventricular remodeling Ventricular Remodeling - physiology |
| title | The Role of Global Longitudinal Strain in Predicting Left Ventricular Reverse Remodeling After Mitral Valve Replacement Surgery in Patients With Primary Mitral Regurgitation |
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