Evaluating the Efficacy of Endoscopic Medialization Laryngoplasty with Autologous Nasal Septal Cartilage Graft in Patients with Unilateral Vocal Fold Paralysis

The evaluation of endoscopic medialization laryngoplasty (ML) using autologous nasal septal cartilage graft as a treatment for unilateral vocal fold paralysis (UVFP) is crucial to inform clinical practice. This study was aimed to assess the efficacy of endoscopic ML on voice quality and patient-reported outcomes in UVFP patients. This single-arm prospective clinical trial was conducted at Mashhad, Iran, involving 18 patients diagnosed with UVFP with different etiology, aged over 18years. All participants underwent endoscopic ML with autologous nasal septal cartilage graft. Primary outcomes included auditory-perceptual evaluation of voice (GRBAS scale), Voice Handicap Index (VHI), and acoustic voice parameters (fundamental frequency (F0), jitter, shimmer, harmonic-to-noise ratio [HNR], and maximum phonation time [MPT]), measured preoperatively and at 2weeks, 2months, and 6months postoperatively. Eighteen patients completed the study. Significant improvements were observed in VHI scores at all postoperative time points (P