Prelimbic cortex perineuronal net expression and social behavior: Impact of adolescent intermittent ethanol exposure

Adolescent intermittent ethanol (AIE) exposure in rats leads to social deficits. Parvalbumin (PV) expressing fast-spiking interneurons in the prelimbic cortex (PrL) contribute to social behavior, and perineuronal nets (PNNs) within the PrL preferentially encompass and regulate PV interneurons. AIE e...

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Veröffentlicht in:	Neuropharmacology 2025-01, Vol.262, p.110195, Article 110195
Hauptverfasser:	Towner, Trevor T., Coleman, Harper J., Goyden, Matthew A., Vore, Andrew S., Papastrat, Kimberly M., Varlinskaya, Elena I., Werner, David F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescence Animals Central Nervous System Depressants - administration & dosage Central Nervous System Depressants - pharmacology Chondroitin ABC Lyase - pharmacology Ethanol Ethanol - administration & dosage Ethanol - pharmacology Female Interneurons - drug effects Interneurons - metabolism Male Nerve Net - drug effects Nerve Net - metabolism Parvalbumins - metabolism Perineuronal nets Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Rats Sex-differences Social Behavior Vesicular Inhibitory Amino Acid Transport Proteins - genetics Vesicular Inhibitory Amino Acid Transport Proteins - metabolism
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