Increased NPM1 inhibit ferroptosis and aggravate renal fibrosis via Nrf2 pathway in chronic kidney disease

Recent findings underscore the significance of ferroptosis, an innovative iron-dependent mode of cell death, in the etiology and progression of chronic kidney disease (CKD). Nucleophosmin 1 (NPM1), a nucleolar protein, contributes to fibrogenesis and modulates cellular functions and mortality. Initi...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2025-01, Vol.1871 (1), p.167551, Article 167551
Hauptverfasser:	Fu, Wenjing, Zhang, Mingyu, Meng, Yilin, Wang, Jingyu, Sun, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chronic kidney disease Fer-1 Ferroptosis Fibrosis - metabolism Humans Iron - metabolism Kidney - metabolism Kidney - pathology Male Mice NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism NPM1 Nuclear factor erythroid 2–related factor 2 Nuclear Proteins - genetics Nuclear Proteins - metabolism Nucleophosmin Rats Renal fibrosis Renal Insufficiency, Chronic - genetics Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - pathology Signal Transduction
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