Oral squamous cell carcinomas drive monocytes into immunosuppressive CD25+CD163+CD206+ macrophages

•Culture media derived from oral squamous cell carcinoma (OSCC) cell lines promoted the differentiation of monocytes into TAM-like macrophages.•OSCC-conditioned macrophages displayed enhanced expression of CD163 and CD206, and inhibited T cell activation and proliferation.•Proteins known to promote...

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Veröffentlicht in:	Oral oncology 2024-12, Vol.159, p.107078, Article 107078
Hauptverfasser:	Pelaez-Prestel, Hector F., Gonzalez-Martin, Fernando, Ras-Carmona, Alvaro, Rocha, Almudena, Cabañas, Carlos, Lafuente, Esther M., Reche, Pedro A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Differentiation Cell Line, Tumor Humans Interleukin-2 Receptor alpha Subunit - metabolism Macrophages - immunology Macrophages - metabolism Mannose Receptor Mannose-Binding Lectins - metabolism Monocytes - immunology Monocytes - metabolism Mouth Neoplasms - immunology Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Receptors, Cell Surface - metabolism Tumor Microenvironment - immunology
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