Manipulation of radixin phosphorylation in the nucleus accumbens core modulates risky choice behavior
Ezrin-Radixin-Moesin (ERM) proteins are actin-binding proteins that contribute to morphological changes in dendritic spines. Despite their significant role in regulating spine structure, the role of ERM proteins in the nucleus accumbnes (NAcc) is not well known, especially in in the context of risk-...
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| Veröffentlicht in: | Progress in neurobiology 2024-11, Vol.242, p.102681, Article 102681 |
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| creator | Kwak, Myung Ji Choi, Su Jeong Cai, Wen Ting Cho, Bo Ram Han, Joonyeup Park, Jong Woo Riecken, Lars Björn Morrison, Helen Choi, Se-Young Kim, Wha Young Kim, Jeong-Hoon |
| description | Ezrin-Radixin-Moesin (ERM) proteins are actin-binding proteins that contribute to morphological changes in dendritic spines. Despite their significant role in regulating spine structure, the role of ERM proteins in the nucleus accumbnes (NAcc) is not well known, especially in in the context of risk-reward decision-making. Here, we measured the relationship between synaptic excitation and inhibition (E/I ratio) from medium spiny neurons in the NAcc core obtained in the rat after a rat gambling task (rGT). Then, after surgery of a phosphomimetic pseudo-active mutant form of radixin (Rdx-T564D) in the NAcc core, we examined its role in synaptic plasticity and the accompanying risk-choice behavior in rGT. We found that basal E/I ratio in the NAcc core was higher in risk-averse rats than risk-seeking rats. However, it was significantly reduced in risk-averse rats similar to that in risk-seeking rats in the presence of Rdx-T564D in the NAcc core. Furthermore, the head sizes of spines were shifted in risk-averse rats expressing Rdx-T564D in the NAcc core, similar to those observed in risk-seeking rats. The effects of Rdx-T564D in risk-averse rats were again manifested as behavioral changes, with reduced selection of optimal choices and increased selection of disadvantageous ones. In this study, we demonstrated that manipulation of radixin phosphorylation status in the NAcc core can alter glutamatergic synaptic transmission and spine structure at this site, as well as risk choice behaviors in the rGT. These novel findings illustrate that radixin in the NAcc core plays a significant role in determining risk preference during the rGT.
•In the NAcc core, risk-seeking rats has lower E/I ratio than risk-averse rats.•Rdx-T564D in the NAcc core shifts risk-averse rats toward risk-seeking.•Rdx-T564D in the NAcc core lowered E/I ratio in the risk-averse rats similar to the level of that in the risk-seeking.•Rdx-T564D in the NAcc core reduced spine head size in the risk-averse rats similar to the level of that in the risk-seeking. |
| doi_str_mv | 10.1016/j.pneurobio.2024.102681 |
| format | Article |
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•In the NAcc core, risk-seeking rats has lower E/I ratio than risk-averse rats.•Rdx-T564D in the NAcc core shifts risk-averse rats toward risk-seeking.•Rdx-T564D in the NAcc core lowered E/I ratio in the risk-averse rats similar to the level of that in the risk-seeking.•Rdx-T564D in the NAcc core reduced spine head size in the risk-averse rats similar to the level of that in the risk-seeking.</description><identifier>ISSN: 0301-0082</identifier><identifier>ISSN: 1873-5118</identifier><identifier>EISSN: 1873-5118</identifier><identifier>DOI: 10.1016/j.pneurobio.2024.102681</identifier><identifier>PMID: 39437882</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Choice Behavior - physiology ; Cytoskeletal Proteins - metabolism ; Decision-making ; Dendritic spine ; Dendritic Spines - metabolism ; Dendritic Spines - physiology ; Male ; Membrane Proteins - metabolism ; Neuronal Plasticity - physiology ; Nucleus accumbens ; Nucleus Accumbens - metabolism ; Phosphorylation - physiology ; Radixin ; Rat gambling task ; Rats ; Rats, Sprague-Dawley ; Risk-Taking</subject><ispartof>Progress in neurobiology, 2024-11, Vol.242, p.102681, Article 102681</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c247t-b0bbe92855f62680bb206f3d8c701a7e3b97c5c9ad54e8aff38c04c6342dc7993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0301008224001175$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39437882$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwak, Myung Ji</creatorcontrib><creatorcontrib>Choi, Su Jeong</creatorcontrib><creatorcontrib>Cai, Wen Ting</creatorcontrib><creatorcontrib>Cho, Bo Ram</creatorcontrib><creatorcontrib>Han, Joonyeup</creatorcontrib><creatorcontrib>Park, Jong Woo</creatorcontrib><creatorcontrib>Riecken, Lars Björn</creatorcontrib><creatorcontrib>Morrison, Helen</creatorcontrib><creatorcontrib>Choi, Se-Young</creatorcontrib><creatorcontrib>Kim, Wha Young</creatorcontrib><creatorcontrib>Kim, Jeong-Hoon</creatorcontrib><title>Manipulation of radixin phosphorylation in the nucleus accumbens core modulates risky choice behavior</title><title>Progress in neurobiology</title><addtitle>Prog Neurobiol</addtitle><description>Ezrin-Radixin-Moesin (ERM) proteins are actin-binding proteins that contribute to morphological changes in dendritic spines. Despite their significant role in regulating spine structure, the role of ERM proteins in the nucleus accumbnes (NAcc) is not well known, especially in in the context of risk-reward decision-making. Here, we measured the relationship between synaptic excitation and inhibition (E/I ratio) from medium spiny neurons in the NAcc core obtained in the rat after a rat gambling task (rGT). Then, after surgery of a phosphomimetic pseudo-active mutant form of radixin (Rdx-T564D) in the NAcc core, we examined its role in synaptic plasticity and the accompanying risk-choice behavior in rGT. We found that basal E/I ratio in the NAcc core was higher in risk-averse rats than risk-seeking rats. However, it was significantly reduced in risk-averse rats similar to that in risk-seeking rats in the presence of Rdx-T564D in the NAcc core. Furthermore, the head sizes of spines were shifted in risk-averse rats expressing Rdx-T564D in the NAcc core, similar to those observed in risk-seeking rats. The effects of Rdx-T564D in risk-averse rats were again manifested as behavioral changes, with reduced selection of optimal choices and increased selection of disadvantageous ones. In this study, we demonstrated that manipulation of radixin phosphorylation status in the NAcc core can alter glutamatergic synaptic transmission and spine structure at this site, as well as risk choice behaviors in the rGT. These novel findings illustrate that radixin in the NAcc core plays a significant role in determining risk preference during the rGT.
•In the NAcc core, risk-seeking rats has lower E/I ratio than risk-averse rats.•Rdx-T564D in the NAcc core shifts risk-averse rats toward risk-seeking.•Rdx-T564D in the NAcc core lowered E/I ratio in the risk-averse rats similar to the level of that in the risk-seeking.•Rdx-T564D in the NAcc core reduced spine head size in the risk-averse rats similar to the level of that in the risk-seeking.</description><subject>Animals</subject><subject>Choice Behavior - physiology</subject><subject>Cytoskeletal Proteins - metabolism</subject><subject>Decision-making</subject><subject>Dendritic spine</subject><subject>Dendritic Spines - metabolism</subject><subject>Dendritic Spines - physiology</subject><subject>Male</subject><subject>Membrane Proteins - metabolism</subject><subject>Neuronal Plasticity - physiology</subject><subject>Nucleus accumbens</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Phosphorylation - physiology</subject><subject>Radixin</subject><subject>Rat gambling task</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Risk-Taking</subject><issn>0301-0082</issn><issn>1873-5118</issn><issn>1873-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v2zAMhoViRZOm_Qudjrs404dtyceg2NYCGXZpz4JM04hS2_Iku1j-fRUkzXUHgiD58iX4EPKVszVnvPy-X48DzsHXzq8FE3nqilLzK7LkWsms4Fx_IUsmGc8Y02JBbmPcM8ZKyeQNWcgql0prsST42w5unDs7OT9Q39JgG_fPDXTc-ZgiHM6j1Jp2SIcZOpwjtQBzX-MQKfiAtPfN0QMjDS6-HSjsvAOkNe7su_Phjly3tot4f84r8vrzx8vjU7b98-v5cbPNQORqympW11gJXRRtmd5JlWBlKxsNinGrUNaVggIq2xQ5atu2UgPLoZS5aEBVlVyRbyffMfi_M8bJ9C4Cdp0d0M_RSM4rJYRMHFZEnaQQfIwBWzMG19twMJyZI2OzNxfG5sjYnBinzYfzkbnusbnsfUJNgs1JgOnVd4fBRHA4ADYuIEym8e6_Rz4AUEeUEg</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Kwak, Myung Ji</creator><creator>Choi, Su Jeong</creator><creator>Cai, Wen Ting</creator><creator>Cho, Bo Ram</creator><creator>Han, Joonyeup</creator><creator>Park, Jong Woo</creator><creator>Riecken, Lars Björn</creator><creator>Morrison, Helen</creator><creator>Choi, Se-Young</creator><creator>Kim, Wha Young</creator><creator>Kim, Jeong-Hoon</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202411</creationdate><title>Manipulation of radixin phosphorylation in the nucleus accumbens core modulates risky choice behavior</title><author>Kwak, Myung Ji ; Choi, Su Jeong ; Cai, Wen Ting ; Cho, Bo Ram ; Han, Joonyeup ; Park, Jong Woo ; Riecken, Lars Björn ; Morrison, Helen ; Choi, Se-Young ; Kim, Wha Young ; Kim, Jeong-Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c247t-b0bbe92855f62680bb206f3d8c701a7e3b97c5c9ad54e8aff38c04c6342dc7993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Choice Behavior - physiology</topic><topic>Cytoskeletal Proteins - metabolism</topic><topic>Decision-making</topic><topic>Dendritic spine</topic><topic>Dendritic Spines - metabolism</topic><topic>Dendritic Spines - physiology</topic><topic>Male</topic><topic>Membrane Proteins - metabolism</topic><topic>Neuronal Plasticity - physiology</topic><topic>Nucleus accumbens</topic><topic>Nucleus Accumbens - metabolism</topic><topic>Phosphorylation - physiology</topic><topic>Radixin</topic><topic>Rat gambling task</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Risk-Taking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwak, Myung Ji</creatorcontrib><creatorcontrib>Choi, Su Jeong</creatorcontrib><creatorcontrib>Cai, Wen Ting</creatorcontrib><creatorcontrib>Cho, Bo Ram</creatorcontrib><creatorcontrib>Han, Joonyeup</creatorcontrib><creatorcontrib>Park, Jong Woo</creatorcontrib><creatorcontrib>Riecken, Lars Björn</creatorcontrib><creatorcontrib>Morrison, Helen</creatorcontrib><creatorcontrib>Choi, Se-Young</creatorcontrib><creatorcontrib>Kim, Wha Young</creatorcontrib><creatorcontrib>Kim, Jeong-Hoon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwak, Myung Ji</au><au>Choi, Su Jeong</au><au>Cai, Wen Ting</au><au>Cho, Bo Ram</au><au>Han, Joonyeup</au><au>Park, Jong Woo</au><au>Riecken, Lars Björn</au><au>Morrison, Helen</au><au>Choi, Se-Young</au><au>Kim, Wha Young</au><au>Kim, Jeong-Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Manipulation of radixin phosphorylation in the nucleus accumbens core modulates risky choice behavior</atitle><jtitle>Progress in neurobiology</jtitle><addtitle>Prog Neurobiol</addtitle><date>2024-11</date><risdate>2024</risdate><volume>242</volume><spage>102681</spage><pages>102681-</pages><artnum>102681</artnum><issn>0301-0082</issn><issn>1873-5118</issn><eissn>1873-5118</eissn><abstract>Ezrin-Radixin-Moesin (ERM) proteins are actin-binding proteins that contribute to morphological changes in dendritic spines. Despite their significant role in regulating spine structure, the role of ERM proteins in the nucleus accumbnes (NAcc) is not well known, especially in in the context of risk-reward decision-making. Here, we measured the relationship between synaptic excitation and inhibition (E/I ratio) from medium spiny neurons in the NAcc core obtained in the rat after a rat gambling task (rGT). Then, after surgery of a phosphomimetic pseudo-active mutant form of radixin (Rdx-T564D) in the NAcc core, we examined its role in synaptic plasticity and the accompanying risk-choice behavior in rGT. We found that basal E/I ratio in the NAcc core was higher in risk-averse rats than risk-seeking rats. However, it was significantly reduced in risk-averse rats similar to that in risk-seeking rats in the presence of Rdx-T564D in the NAcc core. Furthermore, the head sizes of spines were shifted in risk-averse rats expressing Rdx-T564D in the NAcc core, similar to those observed in risk-seeking rats. The effects of Rdx-T564D in risk-averse rats were again manifested as behavioral changes, with reduced selection of optimal choices and increased selection of disadvantageous ones. In this study, we demonstrated that manipulation of radixin phosphorylation status in the NAcc core can alter glutamatergic synaptic transmission and spine structure at this site, as well as risk choice behaviors in the rGT. These novel findings illustrate that radixin in the NAcc core plays a significant role in determining risk preference during the rGT.
•In the NAcc core, risk-seeking rats has lower E/I ratio than risk-averse rats.•Rdx-T564D in the NAcc core shifts risk-averse rats toward risk-seeking.•Rdx-T564D in the NAcc core lowered E/I ratio in the risk-averse rats similar to the level of that in the risk-seeking.•Rdx-T564D in the NAcc core reduced spine head size in the risk-averse rats similar to the level of that in the risk-seeking.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39437882</pmid><doi>10.1016/j.pneurobio.2024.102681</doi></addata></record> |
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| subjects | Animals Choice Behavior - physiology Cytoskeletal Proteins - metabolism Decision-making Dendritic spine Dendritic Spines - metabolism Dendritic Spines - physiology Male Membrane Proteins - metabolism Neuronal Plasticity - physiology Nucleus accumbens Nucleus Accumbens - metabolism Phosphorylation - physiology Radixin Rat gambling task Rats Rats, Sprague-Dawley Risk-Taking |
| title | Manipulation of radixin phosphorylation in the nucleus accumbens core modulates risky choice behavior |
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