Gut microbiota and inflammation analyses reveal the protective effect of medium-chain triglycerides combined with docosahexaenoic acid on cognitive function in APP/PS1 and SAMP8 mice
•Medium-chain triglycerides (MCTs) combined with DHA improve cognitive function.•16S rRNA shows that MCTs combined with DHA optimize gut microbiota composition.•Proteobacteria and Firmicutes/Bacteroidota (F/B) ratio are linked with inflammation.•MCTs combined with DHA down-regulate the abundance of...
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| Veröffentlicht in: | Nutrition research (New York, N.Y.) N.Y.), 2024-12, Vol.132, p.27-39 |
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| creator | Wang, Zehao Sun, Yue Zhang, Dalong Wang, Yue Zhou, Dezheng Li, Wen Yan, Jing Chen, Yongjie Luo, Suhui Qian, Zhiyong Li, Zhenshu Huang, Guowei |
| description | •Medium-chain triglycerides (MCTs) combined with DHA improve cognitive function.•16S rRNA shows that MCTs combined with DHA optimize gut microbiota composition.•Proteobacteria and Firmicutes/Bacteroidota (F/B) ratio are linked with inflammation.•MCTs combined with DHA down-regulate the abundance of Proteobacteria and F/B ratio.
Accumulating evidence has demonstrated that medium-chain triglycerides (MCTs) and docosahexaenoic acid (DHA) positively affect cognitive function. However, it remains unclear whether the improvement is related to the alterations of gut microbiota and inflammation and the impact of the combined intervention. In this study, we hypothesized that the supplementation of MCTs combined with DHA could modulate gut microbiota, inflammation, and improve cognitive function in APPswe/PS1De9 model mice and senescence-accelerated mouse-prone-8, which are two different mouse models used in neurodegeneration research. The mice were divided into four groups: Control group, MCTs group, DHA group, and MCTs + DHA group. The study assessed cognitive function, inflammatory cytokines, and gut microbiota composition. The results showed that supplementation of MCTs + DHA improved spatial learning ability, memory capacity, exploratory behavior; decreased the relative abundance of Proteobacteria; reduced the ratio of Firmicutes/Bacteroidetes; decreased the concentrations of serum interleukin (IL)-2, IL-6, monocyte chemotactic protein-1, tumor necrosis factor-alpha, while increasing the concentration of IL-10. Furthermore, supplementation with MCTs + DHA exhibited significantly superior effects compared to MCTs or DHA alone in reducing inflammation, optimizing gut microbiota composition, and improving cognitive function. In conclusion, supplementation with MCTs + DHA improved cognition function, accompanied with favorable alterations in gut microbiota and inflammation in APPswe/PS1De9 and senescence-accelerated mouse-prone-8 mice.
MCTs and DHA positively modulate the gut microbiota, reduce inflammation, and improve cognitive function. When the supplementation of MCTs combined with DHA intervened, the relative abundance of Proteobacteria, the ratio of F/B, the levels of inflammation were reduced, and cognitive function was improved in APP/PS1 and SAMP8 mice. The mechanisms may be related to gut microbiota and inflammation. DHA, docosahexaenoic acid; F/B, Firmicutes/Bacteroidota; MCTs, medium-chain triglycerides. [Display omitted] |
| doi_str_mv | 10.1016/j.nutres.2024.09.015 |
| format | Article |
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Accumulating evidence has demonstrated that medium-chain triglycerides (MCTs) and docosahexaenoic acid (DHA) positively affect cognitive function. However, it remains unclear whether the improvement is related to the alterations of gut microbiota and inflammation and the impact of the combined intervention. In this study, we hypothesized that the supplementation of MCTs combined with DHA could modulate gut microbiota, inflammation, and improve cognitive function in APPswe/PS1De9 model mice and senescence-accelerated mouse-prone-8, which are two different mouse models used in neurodegeneration research. The mice were divided into four groups: Control group, MCTs group, DHA group, and MCTs + DHA group. The study assessed cognitive function, inflammatory cytokines, and gut microbiota composition. The results showed that supplementation of MCTs + DHA improved spatial learning ability, memory capacity, exploratory behavior; decreased the relative abundance of Proteobacteria; reduced the ratio of Firmicutes/Bacteroidetes; decreased the concentrations of serum interleukin (IL)-2, IL-6, monocyte chemotactic protein-1, tumor necrosis factor-alpha, while increasing the concentration of IL-10. Furthermore, supplementation with MCTs + DHA exhibited significantly superior effects compared to MCTs or DHA alone in reducing inflammation, optimizing gut microbiota composition, and improving cognitive function. In conclusion, supplementation with MCTs + DHA improved cognition function, accompanied with favorable alterations in gut microbiota and inflammation in APPswe/PS1De9 and senescence-accelerated mouse-prone-8 mice.
MCTs and DHA positively modulate the gut microbiota, reduce inflammation, and improve cognitive function. When the supplementation of MCTs combined with DHA intervened, the relative abundance of Proteobacteria, the ratio of F/B, the levels of inflammation were reduced, and cognitive function was improved in APP/PS1 and SAMP8 mice. The mechanisms may be related to gut microbiota and inflammation. DHA, docosahexaenoic acid; F/B, Firmicutes/Bacteroidota; MCTs, medium-chain triglycerides. [Display omitted]</description><identifier>ISSN: 0271-5317</identifier><identifier>ISSN: 1879-0739</identifier><identifier>EISSN: 1879-0739</identifier><identifier>DOI: 10.1016/j.nutres.2024.09.015</identifier><identifier>PMID: 39437526</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alzheimer Disease ; Animals ; APP/PS1 mouse ; Cognition - drug effects ; Cognitive function ; Cytokines - blood ; Cytokines - metabolism ; Dietary Supplements ; Disease Models, Animal ; Docosahexaenoic acid ; Docosahexaenoic Acids - administration & dosage ; Docosahexaenoic Acids - pharmacology ; Gastrointestinal Microbiome - drug effects ; Gut microbiota ; Inflammation - prevention & control ; Inflammatory cytokines ; Male ; Medium-chain triglycerides ; Mice ; Mice, Transgenic ; SAMP8 mouse ; Triglycerides - blood</subject><ispartof>Nutrition research (New York, N.Y.), 2024-12, Vol.132, p.27-39</ispartof><rights>2024 The Author(s)</rights><rights>Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c287t-e9eb9ed5c0ce908a0b9600e2756fe69b4cddd516916840bdb90d1d4e6088e49f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0271531724001295$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39437526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Zehao</creatorcontrib><creatorcontrib>Sun, Yue</creatorcontrib><creatorcontrib>Zhang, Dalong</creatorcontrib><creatorcontrib>Wang, Yue</creatorcontrib><creatorcontrib>Zhou, Dezheng</creatorcontrib><creatorcontrib>Li, Wen</creatorcontrib><creatorcontrib>Yan, Jing</creatorcontrib><creatorcontrib>Chen, Yongjie</creatorcontrib><creatorcontrib>Luo, Suhui</creatorcontrib><creatorcontrib>Qian, Zhiyong</creatorcontrib><creatorcontrib>Li, Zhenshu</creatorcontrib><creatorcontrib>Huang, Guowei</creatorcontrib><title>Gut microbiota and inflammation analyses reveal the protective effect of medium-chain triglycerides combined with docosahexaenoic acid on cognitive function in APP/PS1 and SAMP8 mice</title><title>Nutrition research (New York, N.Y.)</title><addtitle>Nutr Res</addtitle><description>•Medium-chain triglycerides (MCTs) combined with DHA improve cognitive function.•16S rRNA shows that MCTs combined with DHA optimize gut microbiota composition.•Proteobacteria and Firmicutes/Bacteroidota (F/B) ratio are linked with inflammation.•MCTs combined with DHA down-regulate the abundance of Proteobacteria and F/B ratio.
Accumulating evidence has demonstrated that medium-chain triglycerides (MCTs) and docosahexaenoic acid (DHA) positively affect cognitive function. However, it remains unclear whether the improvement is related to the alterations of gut microbiota and inflammation and the impact of the combined intervention. In this study, we hypothesized that the supplementation of MCTs combined with DHA could modulate gut microbiota, inflammation, and improve cognitive function in APPswe/PS1De9 model mice and senescence-accelerated mouse-prone-8, which are two different mouse models used in neurodegeneration research. The mice were divided into four groups: Control group, MCTs group, DHA group, and MCTs + DHA group. The study assessed cognitive function, inflammatory cytokines, and gut microbiota composition. The results showed that supplementation of MCTs + DHA improved spatial learning ability, memory capacity, exploratory behavior; decreased the relative abundance of Proteobacteria; reduced the ratio of Firmicutes/Bacteroidetes; decreased the concentrations of serum interleukin (IL)-2, IL-6, monocyte chemotactic protein-1, tumor necrosis factor-alpha, while increasing the concentration of IL-10. Furthermore, supplementation with MCTs + DHA exhibited significantly superior effects compared to MCTs or DHA alone in reducing inflammation, optimizing gut microbiota composition, and improving cognitive function. In conclusion, supplementation with MCTs + DHA improved cognition function, accompanied with favorable alterations in gut microbiota and inflammation in APPswe/PS1De9 and senescence-accelerated mouse-prone-8 mice.
MCTs and DHA positively modulate the gut microbiota, reduce inflammation, and improve cognitive function. When the supplementation of MCTs combined with DHA intervened, the relative abundance of Proteobacteria, the ratio of F/B, the levels of inflammation were reduced, and cognitive function was improved in APP/PS1 and SAMP8 mice. The mechanisms may be related to gut microbiota and inflammation. DHA, docosahexaenoic acid; F/B, Firmicutes/Bacteroidota; MCTs, medium-chain triglycerides. [Display omitted]</description><subject>Alzheimer Disease</subject><subject>Animals</subject><subject>APP/PS1 mouse</subject><subject>Cognition - drug effects</subject><subject>Cognitive function</subject><subject>Cytokines - blood</subject><subject>Cytokines - metabolism</subject><subject>Dietary Supplements</subject><subject>Disease Models, Animal</subject><subject>Docosahexaenoic acid</subject><subject>Docosahexaenoic Acids - administration & dosage</subject><subject>Docosahexaenoic Acids - pharmacology</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Gut microbiota</subject><subject>Inflammation - prevention & control</subject><subject>Inflammatory cytokines</subject><subject>Male</subject><subject>Medium-chain triglycerides</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>SAMP8 mouse</subject><subject>Triglycerides - blood</subject><issn>0271-5317</issn><issn>1879-0739</issn><issn>1879-0739</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UctuEzEUtRCIhsIfIOQlm5nanqc3SFFVClIRkQpry2PfaW40YxfbE8iP8X04SWHJylfWedx7DiFvOSs54-3VrnRLChBLwURdMlky3jwjK953smBdJZ-TFRMdL5qKdxfkVYw7xnjHq-oluahkXXWNaFfk9-2S6Iwm-AF90lQ7S9GNk55nndC7_KGnQ4RIA-xBTzRtgT4Gn8Ak3AOFccwT9SOdweIyF2ar0dEU8GE6GAhoM9X4eUAHlv7EtKXWGx_1Fn5pcB4N1QYtzU7GPzg8iY6LMyfzrLTebK429_y02P36y6Y_bguvyYtRTxHePL2X5PvHm2_Xn4q7r7efr9d3hRF9lwqQMEiwjWEGJOs1G2TLGIiuaUdo5VAba23DW8nbvmaDHSSz3NbQsr6HWo7VJXl_1s0n_1ggJjVjNDBN2oFfoqo4l50QXDQZWp-hOcsYA4zqMeCsw0Fxpo6NqZ06N6aOjSkmVW4s0949OSxDjvAf6W9FGfDhDIB85x4hqGgQnMlxhxy9sh7_7_AHRiethg</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Wang, Zehao</creator><creator>Sun, Yue</creator><creator>Zhang, Dalong</creator><creator>Wang, Yue</creator><creator>Zhou, Dezheng</creator><creator>Li, Wen</creator><creator>Yan, Jing</creator><creator>Chen, Yongjie</creator><creator>Luo, Suhui</creator><creator>Qian, Zhiyong</creator><creator>Li, Zhenshu</creator><creator>Huang, Guowei</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202412</creationdate><title>Gut microbiota and inflammation analyses reveal the protective effect of medium-chain triglycerides combined with docosahexaenoic acid on cognitive function in APP/PS1 and SAMP8 mice</title><author>Wang, Zehao ; Sun, Yue ; Zhang, Dalong ; Wang, Yue ; Zhou, Dezheng ; Li, Wen ; Yan, Jing ; Chen, Yongjie ; Luo, Suhui ; Qian, Zhiyong ; Li, Zhenshu ; Huang, Guowei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-e9eb9ed5c0ce908a0b9600e2756fe69b4cddd516916840bdb90d1d4e6088e49f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alzheimer Disease</topic><topic>Animals</topic><topic>APP/PS1 mouse</topic><topic>Cognition - drug effects</topic><topic>Cognitive function</topic><topic>Cytokines - blood</topic><topic>Cytokines - metabolism</topic><topic>Dietary Supplements</topic><topic>Disease Models, Animal</topic><topic>Docosahexaenoic acid</topic><topic>Docosahexaenoic Acids - administration & dosage</topic><topic>Docosahexaenoic Acids - pharmacology</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Gut microbiota</topic><topic>Inflammation - prevention & control</topic><topic>Inflammatory cytokines</topic><topic>Male</topic><topic>Medium-chain triglycerides</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>SAMP8 mouse</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Zehao</creatorcontrib><creatorcontrib>Sun, Yue</creatorcontrib><creatorcontrib>Zhang, Dalong</creatorcontrib><creatorcontrib>Wang, Yue</creatorcontrib><creatorcontrib>Zhou, Dezheng</creatorcontrib><creatorcontrib>Li, Wen</creatorcontrib><creatorcontrib>Yan, Jing</creatorcontrib><creatorcontrib>Chen, Yongjie</creatorcontrib><creatorcontrib>Luo, Suhui</creatorcontrib><creatorcontrib>Qian, Zhiyong</creatorcontrib><creatorcontrib>Li, Zhenshu</creatorcontrib><creatorcontrib>Huang, Guowei</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition research (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Zehao</au><au>Sun, Yue</au><au>Zhang, Dalong</au><au>Wang, Yue</au><au>Zhou, Dezheng</au><au>Li, Wen</au><au>Yan, Jing</au><au>Chen, Yongjie</au><au>Luo, Suhui</au><au>Qian, Zhiyong</au><au>Li, Zhenshu</au><au>Huang, Guowei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut microbiota and inflammation analyses reveal the protective effect of medium-chain triglycerides combined with docosahexaenoic acid on cognitive function in APP/PS1 and SAMP8 mice</atitle><jtitle>Nutrition research (New York, N.Y.)</jtitle><addtitle>Nutr Res</addtitle><date>2024-12</date><risdate>2024</risdate><volume>132</volume><spage>27</spage><epage>39</epage><pages>27-39</pages><issn>0271-5317</issn><issn>1879-0739</issn><eissn>1879-0739</eissn><abstract>•Medium-chain triglycerides (MCTs) combined with DHA improve cognitive function.•16S rRNA shows that MCTs combined with DHA optimize gut microbiota composition.•Proteobacteria and Firmicutes/Bacteroidota (F/B) ratio are linked with inflammation.•MCTs combined with DHA down-regulate the abundance of Proteobacteria and F/B ratio.
Accumulating evidence has demonstrated that medium-chain triglycerides (MCTs) and docosahexaenoic acid (DHA) positively affect cognitive function. However, it remains unclear whether the improvement is related to the alterations of gut microbiota and inflammation and the impact of the combined intervention. In this study, we hypothesized that the supplementation of MCTs combined with DHA could modulate gut microbiota, inflammation, and improve cognitive function in APPswe/PS1De9 model mice and senescence-accelerated mouse-prone-8, which are two different mouse models used in neurodegeneration research. The mice were divided into four groups: Control group, MCTs group, DHA group, and MCTs + DHA group. The study assessed cognitive function, inflammatory cytokines, and gut microbiota composition. The results showed that supplementation of MCTs + DHA improved spatial learning ability, memory capacity, exploratory behavior; decreased the relative abundance of Proteobacteria; reduced the ratio of Firmicutes/Bacteroidetes; decreased the concentrations of serum interleukin (IL)-2, IL-6, monocyte chemotactic protein-1, tumor necrosis factor-alpha, while increasing the concentration of IL-10. Furthermore, supplementation with MCTs + DHA exhibited significantly superior effects compared to MCTs or DHA alone in reducing inflammation, optimizing gut microbiota composition, and improving cognitive function. In conclusion, supplementation with MCTs + DHA improved cognition function, accompanied with favorable alterations in gut microbiota and inflammation in APPswe/PS1De9 and senescence-accelerated mouse-prone-8 mice.
MCTs and DHA positively modulate the gut microbiota, reduce inflammation, and improve cognitive function. When the supplementation of MCTs combined with DHA intervened, the relative abundance of Proteobacteria, the ratio of F/B, the levels of inflammation were reduced, and cognitive function was improved in APP/PS1 and SAMP8 mice. The mechanisms may be related to gut microbiota and inflammation. DHA, docosahexaenoic acid; F/B, Firmicutes/Bacteroidota; MCTs, medium-chain triglycerides. [Display omitted]</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39437526</pmid><doi>10.1016/j.nutres.2024.09.015</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrition research (New York, N.Y.), 2024-12, Vol.132, p.27-39 |
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| subjects | Alzheimer Disease Animals APP/PS1 mouse Cognition - drug effects Cognitive function Cytokines - blood Cytokines - metabolism Dietary Supplements Disease Models, Animal Docosahexaenoic acid Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - pharmacology Gastrointestinal Microbiome - drug effects Gut microbiota Inflammation - prevention & control Inflammatory cytokines Male Medium-chain triglycerides Mice Mice, Transgenic SAMP8 mouse Triglycerides - blood |
| title | Gut microbiota and inflammation analyses reveal the protective effect of medium-chain triglycerides combined with docosahexaenoic acid on cognitive function in APP/PS1 and SAMP8 mice |
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