Citreoviridin induces apoptosis through oxidative damage and inflammatory response in PC-12 cells

Citreoviridin (CIT) is a mycotoxin produced by various fungi. Although CIT has been reported to cause neurotoxicity, the molecular mechanism is poorly understood. Therefore, the aim of this study was to investigate the effects and molecular mechanisms of CIT in neurotoxicity. Different concentration...

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Veröffentlicht in:	Toxicology and industrial health 2025-01, Vol.41 (1), p.32-39
Hauptverfasser:	Yang, Jing, Lu, Jiaojiao, Cao, Luoyuan, Dong, Wenxu, Zheng, Xian, Fu, Xianguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Aurovertins - pharmacology Cell cycle Cell Cycle Proteins - metabolism Cytokines Damage DNA damage GADD45 Proteins Gene expression Glutathione Glutathione - metabolism GTP-binding protein Inflammation Inflammation - chemically induced Inflammatory response Interleukin 1 Interleukin-1beta - metabolism Intracellular Intracellular levels L-Lactate dehydrogenase Lactate dehydrogenase Malondialdehyde - metabolism Molecular modelling Mycotoxins Neurotoxicity Oxidative stress Oxidative Stress - drug effects PC12 Cells Rats Reactive oxygen species Reactive Oxygen Species - metabolism Superoxide dismutase Superoxide Dismutase - metabolism Tumor Necrosis Factor-alpha - metabolism Western blotting
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