Interaction of SARS-CoV-2 Spike protein with ACE2 induces cortical actin modulation, including dephosphorylation of ERM proteins and reduction of cortical stiffness

Cell surface cortical actin is a regulatory target for viral infection. We aimed to investigate the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on host cell cortical stiffness, an indicator of cortical actin structure. The receptor-binding domain (RBD) of SARS-Co...

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Veröffentlicht in:	Human cell : official journal of Human Cell Research Society 2024-10, Vol.38 (1), p.3, Article 3
Hauptverfasser:	Do, Thi Ly, Tachibana, Kouichi, Yamamoto, Norio, Ando, Kiyoshi, Isoda, Takaaki, Kihara, Takanori
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Actin Actins - metabolism Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - metabolism Angiotensin-Converting Enzyme 2 - physiology Biomedical and Life Sciences Cell Biology Cell surface Coronaviruses COVID-19 Cytoskeletal Proteins - metabolism Dephosphorylation Ezrin Gynecology Humans Life Sciences Membrane Proteins - metabolism Microfilament Proteins - metabolism Moesin Oncology Phosphorylation Protein Binding Protein Domains Radixin Reproductive Medicine Research Article SARS-CoV-2 - physiology Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - metabolism Spike Glycoprotein, Coronavirus - physiology Spike protein Stem Cells Surgery
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