Systematic Approach in the Development of Chitosan Functionalized Iloperidone Nanoemulsions for Transnasal Delivery, In Vitro and In Vivo Studies

Iloperidone, a second-generation USFDA approved antipsychotic and BCS class II drug shows poor oral bioavailability of 28%. The present research deals with optimization of transnasal nanoemulsions of Iloperidone using Design Expert (Version 11) and further surface functionalization with chitosan for...

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Veröffentlicht in:	AAPS PharmSciTech 2024-10, Vol.25 (8), p.247, Article 247
Hauptverfasser:	Sawant, Niserga D., Tatke, Pratima A., Desai, Namita D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Antipsychotic Agents - administration & dosage Antipsychotic Agents - chemistry Antipsychotic Agents - pharmacokinetics Biochemistry Biological Availability Biomedical and Life Sciences Biomedicine Biotechnology Chitosan - chemistry Drug Carriers - chemistry Drug Delivery Systems - methods Drug Liberation Emulsions - chemistry Goats Isoxazoles - administration & dosage Isoxazoles - chemistry Isoxazoles - pharmacokinetics Male Nanoparticles - chemistry Nasal Mucosa - metabolism Particle Size Pharmacology/Toxicology Pharmacy Piperidines - administration & dosage Piperidines - chemistry Piperidines - pharmacokinetics Rats Rats, Wistar Research Article
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