Integrating metabolomics with network pharmacology to reveal the mechanism of Poria cocos in hyperuricemia treatment

Hyperuricemia is a chronic condition characterized by persistently elevated uric acid levels, often leading to gouty arthritis and renal insufficiency. Poria cocos F.A.Wolf, a traditional Chinese medicinal herb, possesses notable diuretic and anti-inflammatory properties and is widely used to treat...

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Veröffentlicht in:	Journal of ethnopharmacology 2025-01, Vol.337 (Pt 3), p.118977, Article 118977
Hauptverfasser:	Wang, Yiru, Yu, Zhijie, Zhang, Zihao, Mu, Ronghui, Song, Jiayin, Yang, Zijun, Li, Rongshan, Zhang, Jun, Zhu, Xuehui, Gong, Min, Wu, Xiaohui, Wang, Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Urea Nitrogen Creatinine - blood Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Hyperuricemia Hyperuricemia - drug therapy Kidney - drug effects Kidney - metabolism Liver - drug effects Liver - metabolism Male Metabolomics Molecular Docking Simulation Network Pharmacology Poria cocos F.A.Wolf Rats Rats, Sprague-Dawley Uric Acid - blood Wolfiporia - chemistry Xanthine Oxidase - metabolism
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