Pregnancy zone protein, a potential research target in multiple diseases
•PZP is downregulated in diabetes, obesity, and metabolic dysfunction-associated fatty liver disease.•High PZP improve dysregulation of glucose and lipid metabolism.•PZP is reduced in breast cancer, hepatocellular carcinoma, and lung adenocarcinoma.•PZP is elevated in diabetics with lung adenocarcin...
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| Veröffentlicht in: | Gene 2025-01, Vol.935, p.149013, Article 149013 |
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| creator | Wu, You Zhao, Zhicong Deng, Xia Jia, Jue Yuan, Guoyue |
| description | •PZP is downregulated in diabetes, obesity, and metabolic dysfunction-associated fatty liver disease.•High PZP improve dysregulation of glucose and lipid metabolism.•PZP is reduced in breast cancer, hepatocellular carcinoma, and lung adenocarcinoma.•PZP is elevated in diabetics with lung adenocarcinoma or colorectal cancer.
Pregnancy zone protein (PZP) is an antiprotease-resistant immunosuppressant belonging to the α-macroglobulin (αM) protein family. PZP is secreted by the liver and was found to be upregulated in plasma during pregnancy. α-2-macroglobulin (Α2M) shares 71 % serial homology with PZP, but low PZP levels do not lead to increased A2M levels in pregnancy. PZP can interact with several factors such as low-density lipoprotein receptor-associated protein (LRP), transforming growth factor-β (TGF-β), 78 kDa glucose-regulated protein (GRP78), and glycoside A (GdA). PZP is involved in the development of glycolipid metabolism disorders, bronchiectasis, Alzheimer’s disease (AD), rheumatoid arthritis (RA), myocardial infarction (MI) and inflammatory bowel disease (IBD). PZP is also associated with the progression of tumorigenesis such as breast cancer (BC), homologyepatocellular carcinoma (HCC), lung adenocarcinoma (LAC), and colorectal cancer (CRC). Therefore, this review analyzes the role of PZP in pathophysiology of various diseases. |
| doi_str_mv | 10.1016/j.gene.2024.149013 |
| format | Article |
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Pregnancy zone protein (PZP) is an antiprotease-resistant immunosuppressant belonging to the α-macroglobulin (αM) protein family. PZP is secreted by the liver and was found to be upregulated in plasma during pregnancy. α-2-macroglobulin (Α2M) shares 71 % serial homology with PZP, but low PZP levels do not lead to increased A2M levels in pregnancy. PZP can interact with several factors such as low-density lipoprotein receptor-associated protein (LRP), transforming growth factor-β (TGF-β), 78 kDa glucose-regulated protein (GRP78), and glycoside A (GdA). PZP is involved in the development of glycolipid metabolism disorders, bronchiectasis, Alzheimer’s disease (AD), rheumatoid arthritis (RA), myocardial infarction (MI) and inflammatory bowel disease (IBD). PZP is also associated with the progression of tumorigenesis such as breast cancer (BC), homologyepatocellular carcinoma (HCC), lung adenocarcinoma (LAC), and colorectal cancer (CRC). Therefore, this review analyzes the role of PZP in pathophysiology of various diseases.</description><identifier>ISSN: 0378-1119</identifier><identifier>ISSN: 1879-0038</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/j.gene.2024.149013</identifier><identifier>PMID: 39433266</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>adenocarcinoma ; alpha-Macroglobulins ; Alzheimer Disease - genetics ; Alzheimer Disease - metabolism ; Alzheimer’s disease (AD) ; Animals ; Arthritis, Rheumatoid - genetics ; Arthritis, Rheumatoid - metabolism ; breast neoplasms ; carcinogenesis ; colorectal neoplasms ; family ; Female ; genes ; glycolipids ; glycosides ; Humans ; immunosuppressive agents ; inflammatory bowel disease ; Inflammatory diseases ; liver ; low density lipoprotein ; lungs ; Metabolic diseases ; metabolism ; myocardial infarction ; Neoplasms - genetics ; Neoplasms - metabolism ; pathophysiology ; Pregnancy ; Pregnancy zone protein (PZP) ; Pregnancy-Associated alpha 2-Macroglobulins - metabolism ; rheumatoid arthritis ; Tumors</subject><ispartof>Gene, 2025-01, Vol.935, p.149013, Article 149013</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c270t-e4366b11dca5db927f27b5ebcd67275254a3a21cac084f6c418241185aeac5bf3</cites><orcidid>0009-0003-5168-0798</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378111924008941$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39433266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, You</creatorcontrib><creatorcontrib>Zhao, Zhicong</creatorcontrib><creatorcontrib>Deng, Xia</creatorcontrib><creatorcontrib>Jia, Jue</creatorcontrib><creatorcontrib>Yuan, Guoyue</creatorcontrib><title>Pregnancy zone protein, a potential research target in multiple diseases</title><title>Gene</title><addtitle>Gene</addtitle><description>•PZP is downregulated in diabetes, obesity, and metabolic dysfunction-associated fatty liver disease.•High PZP improve dysregulation of glucose and lipid metabolism.•PZP is reduced in breast cancer, hepatocellular carcinoma, and lung adenocarcinoma.•PZP is elevated in diabetics with lung adenocarcinoma or colorectal cancer.
Pregnancy zone protein (PZP) is an antiprotease-resistant immunosuppressant belonging to the α-macroglobulin (αM) protein family. PZP is secreted by the liver and was found to be upregulated in plasma during pregnancy. α-2-macroglobulin (Α2M) shares 71 % serial homology with PZP, but low PZP levels do not lead to increased A2M levels in pregnancy. PZP can interact with several factors such as low-density lipoprotein receptor-associated protein (LRP), transforming growth factor-β (TGF-β), 78 kDa glucose-regulated protein (GRP78), and glycoside A (GdA). PZP is involved in the development of glycolipid metabolism disorders, bronchiectasis, Alzheimer’s disease (AD), rheumatoid arthritis (RA), myocardial infarction (MI) and inflammatory bowel disease (IBD). PZP is also associated with the progression of tumorigenesis such as breast cancer (BC), homologyepatocellular carcinoma (HCC), lung adenocarcinoma (LAC), and colorectal cancer (CRC). Therefore, this review analyzes the role of PZP in pathophysiology of various diseases.</description><subject>adenocarcinoma</subject><subject>alpha-Macroglobulins</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer’s disease (AD)</subject><subject>Animals</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>breast neoplasms</subject><subject>carcinogenesis</subject><subject>colorectal neoplasms</subject><subject>family</subject><subject>Female</subject><subject>genes</subject><subject>glycolipids</subject><subject>glycosides</subject><subject>Humans</subject><subject>immunosuppressive agents</subject><subject>inflammatory bowel disease</subject><subject>Inflammatory diseases</subject><subject>liver</subject><subject>low density lipoprotein</subject><subject>lungs</subject><subject>Metabolic diseases</subject><subject>metabolism</subject><subject>myocardial infarction</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>pathophysiology</subject><subject>Pregnancy</subject><subject>Pregnancy zone protein (PZP)</subject><subject>Pregnancy-Associated alpha 2-Macroglobulins - metabolism</subject><subject>rheumatoid arthritis</subject><subject>Tumors</subject><issn>0378-1119</issn><issn>1879-0038</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtKxDAUhoMoOl5ewIVk6cKOObm1BTci3kDQha5Dmp6OGTrpmHQEfXozjLoUk0UOnO__CR8hx8CmwECfz6czDDjljMspyJqB2CITqMq6YExU22TCRFkVAFDvkf2U5iwfpfgu2RO1FIJrPSF3TxFnwQb3QT-HgHQZhxF9OKOWLvMURm97GjGhje6VjjbOcKQ-0MWqH_2yR9r6vEuYDslOZ_uER9_vAXm5uX6-uiseHm_vry4fCsdLNhYohdYNQOusapualx0vG4WNa3XJS8WVtMJycNaxSnbaSai4BKiURetU04kDcrrpzT99W2EazcInh31vAw6rZAQoCaquK_UPFOp8tRYZ5RvUxSGliJ1ZRr-w8cMAM2vZZm7Wss1attnIzqGT7_5Vs8D2N_JjNwMXGwCzkHeP0STnMThsfUQ3mnbwf_V_AWxVj5M</recordid><startdate>20250130</startdate><enddate>20250130</enddate><creator>Wu, You</creator><creator>Zhao, Zhicong</creator><creator>Deng, Xia</creator><creator>Jia, Jue</creator><creator>Yuan, Guoyue</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0009-0003-5168-0798</orcidid></search><sort><creationdate>20250130</creationdate><title>Pregnancy zone protein, a potential research target in multiple diseases</title><author>Wu, You ; Zhao, Zhicong ; Deng, Xia ; Jia, Jue ; Yuan, Guoyue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-e4366b11dca5db927f27b5ebcd67275254a3a21cac084f6c418241185aeac5bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>adenocarcinoma</topic><topic>alpha-Macroglobulins</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer’s disease (AD)</topic><topic>Animals</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>Arthritis, Rheumatoid - metabolism</topic><topic>breast neoplasms</topic><topic>carcinogenesis</topic><topic>colorectal neoplasms</topic><topic>family</topic><topic>Female</topic><topic>genes</topic><topic>glycolipids</topic><topic>glycosides</topic><topic>Humans</topic><topic>immunosuppressive agents</topic><topic>inflammatory bowel disease</topic><topic>Inflammatory diseases</topic><topic>liver</topic><topic>low density lipoprotein</topic><topic>lungs</topic><topic>Metabolic diseases</topic><topic>metabolism</topic><topic>myocardial infarction</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>pathophysiology</topic><topic>Pregnancy</topic><topic>Pregnancy zone protein (PZP)</topic><topic>Pregnancy-Associated alpha 2-Macroglobulins - metabolism</topic><topic>rheumatoid arthritis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, You</creatorcontrib><creatorcontrib>Zhao, Zhicong</creatorcontrib><creatorcontrib>Deng, Xia</creatorcontrib><creatorcontrib>Jia, Jue</creatorcontrib><creatorcontrib>Yuan, Guoyue</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, You</au><au>Zhao, Zhicong</au><au>Deng, Xia</au><au>Jia, Jue</au><au>Yuan, Guoyue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy zone protein, a potential research target in multiple diseases</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>2025-01-30</date><risdate>2025</risdate><volume>935</volume><spage>149013</spage><pages>149013-</pages><artnum>149013</artnum><issn>0378-1119</issn><issn>1879-0038</issn><eissn>1879-0038</eissn><abstract>•PZP is downregulated in diabetes, obesity, and metabolic dysfunction-associated fatty liver disease.•High PZP improve dysregulation of glucose and lipid metabolism.•PZP is reduced in breast cancer, hepatocellular carcinoma, and lung adenocarcinoma.•PZP is elevated in diabetics with lung adenocarcinoma or colorectal cancer.
Pregnancy zone protein (PZP) is an antiprotease-resistant immunosuppressant belonging to the α-macroglobulin (αM) protein family. PZP is secreted by the liver and was found to be upregulated in plasma during pregnancy. α-2-macroglobulin (Α2M) shares 71 % serial homology with PZP, but low PZP levels do not lead to increased A2M levels in pregnancy. PZP can interact with several factors such as low-density lipoprotein receptor-associated protein (LRP), transforming growth factor-β (TGF-β), 78 kDa glucose-regulated protein (GRP78), and glycoside A (GdA). PZP is involved in the development of glycolipid metabolism disorders, bronchiectasis, Alzheimer’s disease (AD), rheumatoid arthritis (RA), myocardial infarction (MI) and inflammatory bowel disease (IBD). PZP is also associated with the progression of tumorigenesis such as breast cancer (BC), homologyepatocellular carcinoma (HCC), lung adenocarcinoma (LAC), and colorectal cancer (CRC). Therefore, this review analyzes the role of PZP in pathophysiology of various diseases.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39433266</pmid><doi>10.1016/j.gene.2024.149013</doi><orcidid>https://orcid.org/0009-0003-5168-0798</orcidid></addata></record> |
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| subjects | adenocarcinoma alpha-Macroglobulins Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer’s disease (AD) Animals Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - metabolism breast neoplasms carcinogenesis colorectal neoplasms family Female genes glycolipids glycosides Humans immunosuppressive agents inflammatory bowel disease Inflammatory diseases liver low density lipoprotein lungs Metabolic diseases metabolism myocardial infarction Neoplasms - genetics Neoplasms - metabolism pathophysiology Pregnancy Pregnancy zone protein (PZP) Pregnancy-Associated alpha 2-Macroglobulins - metabolism rheumatoid arthritis Tumors |
| title | Pregnancy zone protein, a potential research target in multiple diseases |
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