Inhibition of proteasome activity facilitates definitive endodermal specification of pluripotent stem cells by influencing YAP signalling

The knowledge of the molecular players that regulate the generation of endoderm cells is imperative to obtain homogenous population of pancreatic β-cells from stem cells. The Ubiquitin proteasome system (UPS) has been envisaged as a crucial intracellular protein degradation system, but its role in t...

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Veröffentlicht in:	Life sciences (1973) 2024-12, Vol.358, p.123160, Article 123160
Hauptverfasser:	Ashok, Akshaya, Ashwathnarayan, Ashwini, Bhaskar, Smitha, Shekar, Spandana, Kalathur, Guruprasad, Prasanna, Jyothi, Kumar, Anujith
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Cell Differentiation - drug effects Embryonic stem cells Endoderm - cytology Endoderm - metabolism Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Mice Pancreatic β-cells Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors - pharmacology Signal Transduction Ubiquitin Proteasome System (UPS) Unfolded protein response YAP signalling YAP-Signaling Proteins - metabolism
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