Comparative evaluation of efficacy of Trayodashang Guggul versus Rasona Pinda as an adjuvant with Katibasti in the management of Grudhrasi (Sciatica): A randomized controlled trial [version 3; peer review: 2 approved with reservations]
Background In ayurveda, sciatica can be correlated to ' Grudhrasi' under Vata Nanatmaja-Vyadhi (neurological disorders caused by Vata, one of the bodily humour). In this mainly bodily humours vata and kapha are vitiating producing symptoms like piercing pain, stiffness, twitching, numbness...
Gespeichert in:
| Veröffentlicht in: | F1000 research 2024, Vol.13, p.9 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | 9 |
| container_title | F1000 research |
| container_volume | 13 |
| creator | Rai, Mayank Misar, Sadhana Gamne, Reeya |
| description | Background
In ayurveda, sciatica can be correlated to '
Grudhrasi' under
Vata Nanatmaja-Vyadhi (neurological disorders caused by
Vata, one of the bodily humour). In this mainly bodily humours
vata and
kapha are vitiating producing symptoms like piercing pain, stiffness, twitching, numbness and pain radiating from lumbosacral region to lower limb up to the foot. Therapeutic plan includes stabilizing and bringing back the vitiated vata and kapha humours to equilibrium. The prevalence of sciatica varies considerably ranging from 3.8% in the working population to 7.9% in the nonworking population.
Aim
Comparative evaluation of efficacy of
Rasonapinda and
Trayodashang guggul as an adjuvant to
katibasti (oil pooling therapy) in the management of
Grudhrasi (Sciatica).
Objectives
To assess the efficacy of
Rasonapinda as an adjuvant to
katibasti in subjective and objective parameters of
Grudhrasi (Sciatica). To assess the efficacy of
Trayodashang guggul as an adjuvant to
katibasti in subjective and objective parameters of
Grudhrasi (Sciatica). To compare the efficacy of
Rasonapinda and
Trayodashang guggul as an adjuvant to
katibasti in subjective and objective parameters. Standardisation of
Rasonapinda (modified formvati).
Methods
In this study, a total of 60 patients will be enrolled and divided equally into two groups. In group A,
Trayodashang Guggul 500 mg twice a day after meal with warm water for 30 days adjuvant with katibasti for the initial 7 days will be given. In group B,
Rasonapinda 500 mg twice a day after meal with warm water adjuvant with katibasti for the initial 7 days will be given for 30 days.
Result
The result will be assessed on baseline of subjective and objective parameters and data will be compared after treatment.
Conclusions
It will be based on observations and results obtained.
Trial registration
CTRI No. - CTRI/2022/12/048534 Dated - 27/12/2022. |
| doi_str_mv | 10.12688/f1000research.139568.3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3118837090</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3118837090</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2333-16d5f31b2dca68388d4f1a69446ac74965f938c96aafa2fb7004efa1ccb3ff543</originalsourceid><addsrcrecordid>eNqFkstuEzEUhkcIRKvSV4AjsSmLBF8mzrhdVREERCUQlBVCoxOPnTiasVN7PFV4Gp6F9-EdcJJy3bDyv_jO52PrL4onlIwpE1X13FBCSNBRY1CrMeVyIqoxv1ccM1KKES0Ju_9HPipOY1znCSIlF2z6sDjismRSlPS4-D7z3QYD9nbQoAdsU47egTegjbEK1XaXrwNufYNxhW4J87RcphYGHWKK8B6jdwjvrGsQMAI6wGadBnQ93Np-BW-ycYGxt2Ad9CsNHTpc6k5nIKvnITWrgNHC2QdlM6vw2fm3r3AJAV3jO_tFN6C864Nv2xz7YLGFT7vbd4vyC9hoHSDowerbc2CAm03wQyb3t---KQz7R8XPj4oHBtuoT-_Ok-LjyxfXs1ejq7fz17PLq5FinPMRFc3EcLpgjUJR8apqSkNRyLIUqKalFBMjeaWkQDTIzGJKSKkNUqUW3JhJyU-Ks4M3b3KTdOzrzkal2xad9inWnNKq4lMiSUaf_oOufQoub5cpxmTFKi4yNT1QKvgYgzb1JtgOw7ampN6Xov6rFPWhFDXPk4_v_GnR6ebX3M8KZODiABhUqe23O0392_Mf_Q-j3c2S</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3122982836</pqid></control><display><type>article</type><title>Comparative evaluation of efficacy of Trayodashang Guggul versus Rasona Pinda as an adjuvant with Katibasti in the management of Grudhrasi (Sciatica): A randomized controlled trial [version 3; peer review: 2 approved with reservations]</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Rai, Mayank ; Misar, Sadhana ; Gamne, Reeya</creator><creatorcontrib>Rai, Mayank ; Misar, Sadhana ; Gamne, Reeya</creatorcontrib><description>Background
In ayurveda, sciatica can be correlated to '
Grudhrasi' under
Vata Nanatmaja-Vyadhi (neurological disorders caused by
Vata, one of the bodily humour). In this mainly bodily humours
vata and
kapha are vitiating producing symptoms like piercing pain, stiffness, twitching, numbness and pain radiating from lumbosacral region to lower limb up to the foot. Therapeutic plan includes stabilizing and bringing back the vitiated vata and kapha humours to equilibrium. The prevalence of sciatica varies considerably ranging from 3.8% in the working population to 7.9% in the nonworking population.
Aim
Comparative evaluation of efficacy of
Rasonapinda and
Trayodashang guggul as an adjuvant to
katibasti (oil pooling therapy) in the management of
Grudhrasi (Sciatica).
Objectives
To assess the efficacy of
Rasonapinda as an adjuvant to
katibasti in subjective and objective parameters of
Grudhrasi (Sciatica). To assess the efficacy of
Trayodashang guggul as an adjuvant to
katibasti in subjective and objective parameters of
Grudhrasi (Sciatica). To compare the efficacy of
Rasonapinda and
Trayodashang guggul as an adjuvant to
katibasti in subjective and objective parameters. Standardisation of
Rasonapinda (modified formvati).
Methods
In this study, a total of 60 patients will be enrolled and divided equally into two groups. In group A,
Trayodashang Guggul 500 mg twice a day after meal with warm water for 30 days adjuvant with katibasti for the initial 7 days will be given. In group B,
Rasonapinda 500 mg twice a day after meal with warm water adjuvant with katibasti for the initial 7 days will be given for 30 days.
Result
The result will be assessed on baseline of subjective and objective parameters and data will be compared after treatment.
Conclusions
It will be based on observations and results obtained.
Trial registration
CTRI No. - CTRI/2022/12/048534 Dated - 27/12/2022.</description><identifier>ISSN: 2046-1402</identifier><identifier>EISSN: 2046-1402</identifier><identifier>DOI: 10.12688/f1000research.139568.3</identifier><identifier>PMID: 39429641</identifier><language>eng</language><publisher>England: Faculty of 1000 Ltd</publisher><subject>Adjuvants ; Adult ; Analgesics ; Ayurvedic medicine ; Commiphora ; Committees ; Female ; Gandhi, Mohandas Karamchand (1869-1948) ; Humans ; Informed consent ; Ingredients ; Male ; Medical research ; Medicine, Ayurvedic ; Middle Aged ; Neurological diseases ; Pain ; Pathogenesis ; Patients ; Plant Extracts - therapeutic use ; Plant Gums - therapeutic use ; Treatment Outcome ; Tuberculosis ; Twitching</subject><ispartof>F1000 research, 2024, Vol.13, p.9</ispartof><rights>Copyright: © 2024 Rai M et al.</rights><rights>Copyright: © 2024 Rai M et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2333-16d5f31b2dca68388d4f1a69446ac74965f938c96aafa2fb7004efa1ccb3ff543</cites><orcidid>0000-0003-0165-0171 ; 0000-0002-8960-2977 ; 0000-0002-2519-5620</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39429641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rai, Mayank</creatorcontrib><creatorcontrib>Misar, Sadhana</creatorcontrib><creatorcontrib>Gamne, Reeya</creatorcontrib><title>Comparative evaluation of efficacy of Trayodashang Guggul versus Rasona Pinda as an adjuvant with Katibasti in the management of Grudhrasi (Sciatica): A randomized controlled trial [version 3; peer review: 2 approved with reservations]</title><title>F1000 research</title><addtitle>F1000Res</addtitle><description>Background
In ayurveda, sciatica can be correlated to '
Grudhrasi' under
Vata Nanatmaja-Vyadhi (neurological disorders caused by
Vata, one of the bodily humour). In this mainly bodily humours
vata and
kapha are vitiating producing symptoms like piercing pain, stiffness, twitching, numbness and pain radiating from lumbosacral region to lower limb up to the foot. Therapeutic plan includes stabilizing and bringing back the vitiated vata and kapha humours to equilibrium. The prevalence of sciatica varies considerably ranging from 3.8% in the working population to 7.9% in the nonworking population.
Aim
Comparative evaluation of efficacy of
Rasonapinda and
Trayodashang guggul as an adjuvant to
katibasti (oil pooling therapy) in the management of
Grudhrasi (Sciatica).
Objectives
To assess the efficacy of
Rasonapinda as an adjuvant to
katibasti in subjective and objective parameters of
Grudhrasi (Sciatica). To assess the efficacy of
Trayodashang guggul as an adjuvant to
katibasti in subjective and objective parameters of
Grudhrasi (Sciatica). To compare the efficacy of
Rasonapinda and
Trayodashang guggul as an adjuvant to
katibasti in subjective and objective parameters. Standardisation of
Rasonapinda (modified formvati).
Methods
In this study, a total of 60 patients will be enrolled and divided equally into two groups. In group A,
Trayodashang Guggul 500 mg twice a day after meal with warm water for 30 days adjuvant with katibasti for the initial 7 days will be given. In group B,
Rasonapinda 500 mg twice a day after meal with warm water adjuvant with katibasti for the initial 7 days will be given for 30 days.
Result
The result will be assessed on baseline of subjective and objective parameters and data will be compared after treatment.
Conclusions
It will be based on observations and results obtained.
Trial registration
CTRI No. - CTRI/2022/12/048534 Dated - 27/12/2022.</description><subject>Adjuvants</subject><subject>Adult</subject><subject>Analgesics</subject><subject>Ayurvedic medicine</subject><subject>Commiphora</subject><subject>Committees</subject><subject>Female</subject><subject>Gandhi, Mohandas Karamchand (1869-1948)</subject><subject>Humans</subject><subject>Informed consent</subject><subject>Ingredients</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Ayurvedic</subject><subject>Middle Aged</subject><subject>Neurological diseases</subject><subject>Pain</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Gums - therapeutic use</subject><subject>Treatment Outcome</subject><subject>Tuberculosis</subject><subject>Twitching</subject><issn>2046-1402</issn><issn>2046-1402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkstuEzEUhkcIRKvSV4AjsSmLBF8mzrhdVREERCUQlBVCoxOPnTiasVN7PFV4Gp6F9-EdcJJy3bDyv_jO52PrL4onlIwpE1X13FBCSNBRY1CrMeVyIqoxv1ccM1KKES0Ju_9HPipOY1znCSIlF2z6sDjismRSlPS4-D7z3QYD9nbQoAdsU47egTegjbEK1XaXrwNufYNxhW4J87RcphYGHWKK8B6jdwjvrGsQMAI6wGadBnQ93Np-BW-ycYGxt2Ad9CsNHTpc6k5nIKvnITWrgNHC2QdlM6vw2fm3r3AJAV3jO_tFN6C864Nv2xz7YLGFT7vbd4vyC9hoHSDowerbc2CAm03wQyb3t---KQz7R8XPj4oHBtuoT-_Ok-LjyxfXs1ejq7fz17PLq5FinPMRFc3EcLpgjUJR8apqSkNRyLIUqKalFBMjeaWkQDTIzGJKSKkNUqUW3JhJyU-Ks4M3b3KTdOzrzkal2xad9inWnNKq4lMiSUaf_oOufQoub5cpxmTFKi4yNT1QKvgYgzb1JtgOw7ampN6Xov6rFPWhFDXPk4_v_GnR6ebX3M8KZODiABhUqe23O0392_Mf_Q-j3c2S</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Rai, Mayank</creator><creator>Misar, Sadhana</creator><creator>Gamne, Reeya</creator><general>Faculty of 1000 Ltd</general><scope>C-E</scope><scope>CH4</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0165-0171</orcidid><orcidid>https://orcid.org/0000-0002-8960-2977</orcidid><orcidid>https://orcid.org/0000-0002-2519-5620</orcidid></search><sort><creationdate>2024</creationdate><title>Comparative evaluation of efficacy of Trayodashang Guggul versus Rasona Pinda as an adjuvant with Katibasti in the management of Grudhrasi (Sciatica): A randomized controlled trial [version 3; peer review: 2 approved with reservations]</title><author>Rai, Mayank ; Misar, Sadhana ; Gamne, Reeya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2333-16d5f31b2dca68388d4f1a69446ac74965f938c96aafa2fb7004efa1ccb3ff543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adjuvants</topic><topic>Adult</topic><topic>Analgesics</topic><topic>Ayurvedic medicine</topic><topic>Commiphora</topic><topic>Committees</topic><topic>Female</topic><topic>Gandhi, Mohandas Karamchand (1869-1948)</topic><topic>Humans</topic><topic>Informed consent</topic><topic>Ingredients</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Ayurvedic</topic><topic>Middle Aged</topic><topic>Neurological diseases</topic><topic>Pain</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Gums - therapeutic use</topic><topic>Treatment Outcome</topic><topic>Tuberculosis</topic><topic>Twitching</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rai, Mayank</creatorcontrib><creatorcontrib>Misar, Sadhana</creatorcontrib><creatorcontrib>Gamne, Reeya</creatorcontrib><collection>F1000Research</collection><collection>Faculty of 1000</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>F1000 research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rai, Mayank</au><au>Misar, Sadhana</au><au>Gamne, Reeya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative evaluation of efficacy of Trayodashang Guggul versus Rasona Pinda as an adjuvant with Katibasti in the management of Grudhrasi (Sciatica): A randomized controlled trial [version 3; peer review: 2 approved with reservations]</atitle><jtitle>F1000 research</jtitle><addtitle>F1000Res</addtitle><date>2024</date><risdate>2024</risdate><volume>13</volume><spage>9</spage><pages>9-</pages><issn>2046-1402</issn><eissn>2046-1402</eissn><abstract>Background
In ayurveda, sciatica can be correlated to '
Grudhrasi' under
Vata Nanatmaja-Vyadhi (neurological disorders caused by
Vata, one of the bodily humour). In this mainly bodily humours
vata and
kapha are vitiating producing symptoms like piercing pain, stiffness, twitching, numbness and pain radiating from lumbosacral region to lower limb up to the foot. Therapeutic plan includes stabilizing and bringing back the vitiated vata and kapha humours to equilibrium. The prevalence of sciatica varies considerably ranging from 3.8% in the working population to 7.9% in the nonworking population.
Aim
Comparative evaluation of efficacy of
Rasonapinda and
Trayodashang guggul as an adjuvant to
katibasti (oil pooling therapy) in the management of
Grudhrasi (Sciatica).
Objectives
To assess the efficacy of
Rasonapinda as an adjuvant to
katibasti in subjective and objective parameters of
Grudhrasi (Sciatica). To assess the efficacy of
Trayodashang guggul as an adjuvant to
katibasti in subjective and objective parameters of
Grudhrasi (Sciatica). To compare the efficacy of
Rasonapinda and
Trayodashang guggul as an adjuvant to
katibasti in subjective and objective parameters. Standardisation of
Rasonapinda (modified formvati).
Methods
In this study, a total of 60 patients will be enrolled and divided equally into two groups. In group A,
Trayodashang Guggul 500 mg twice a day after meal with warm water for 30 days adjuvant with katibasti for the initial 7 days will be given. In group B,
Rasonapinda 500 mg twice a day after meal with warm water adjuvant with katibasti for the initial 7 days will be given for 30 days.
Result
The result will be assessed on baseline of subjective and objective parameters and data will be compared after treatment.
Conclusions
It will be based on observations and results obtained.
Trial registration
CTRI No. - CTRI/2022/12/048534 Dated - 27/12/2022.</abstract><cop>England</cop><pub>Faculty of 1000 Ltd</pub><pmid>39429641</pmid><doi>10.12688/f1000research.139568.3</doi><orcidid>https://orcid.org/0000-0003-0165-0171</orcidid><orcidid>https://orcid.org/0000-0002-8960-2977</orcidid><orcidid>https://orcid.org/0000-0002-2519-5620</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2046-1402 |
| ispartof | F1000 research, 2024, Vol.13, p.9 |
| issn | 2046-1402 2046-1402 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3118837090 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adjuvants Adult Analgesics Ayurvedic medicine Commiphora Committees Female Gandhi, Mohandas Karamchand (1869-1948) Humans Informed consent Ingredients Male Medical research Medicine, Ayurvedic Middle Aged Neurological diseases Pain Pathogenesis Patients Plant Extracts - therapeutic use Plant Gums - therapeutic use Treatment Outcome Tuberculosis Twitching |
| title | Comparative evaluation of efficacy of Trayodashang Guggul versus Rasona Pinda as an adjuvant with Katibasti in the management of Grudhrasi (Sciatica): A randomized controlled trial [version 3; peer review: 2 approved with reservations] |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T20%3A14%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparative%20evaluation%20of%20efficacy%20of%20Trayodashang%20Guggul%20versus%20Rasona%20Pinda%20as%20an%20adjuvant%20with%20Katibasti%20in%20the%20management%20of%20Grudhrasi%20(Sciatica):%C2%A0%20A%20randomized%20controlled%20trial%20%5Bversion%203;%20peer%20review:%202%20approved%20with%20reservations%5D&rft.jtitle=F1000%20research&rft.au=Rai,%20Mayank&rft.date=2024&rft.volume=13&rft.spage=9&rft.pages=9-&rft.issn=2046-1402&rft.eissn=2046-1402&rft_id=info:doi/10.12688/f1000research.139568.3&rft_dat=%3Cproquest_cross%3E3118837090%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3122982836&rft_id=info:pmid/39429641&rfr_iscdi=true |