Clinical usefulness of C-reactive protein-albumin-lymphocyte (CALLY) index as a prognostic biomarker in patients undergoing surgical resection of pancreatic cancer
Purpose The C-reactive protein-albumin-lymphocyte (CALLY) index, which simultaneously evaluates the nutritional, immunological, and inflammatory statuses, is a new prognostic biomarker in patients with various cancers; however, no study has reported the clinical significance of the CALLY index in pa...
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| Veröffentlicht in: | Langenbeck's archives of surgery 2024-10, Vol.409 (1), p.317, Article 317 |
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| creator | Kawahara, Shinnosuke Aoyama, Toru Murakawa, Masaaki Kanemoto, Rei Matsushita, Naohiko Hashimoto, Itaru Kamiya, Mariko Maezawa, Yukio Kobayashi, Satoshi Ueno, Makoto Yamamoto, Naoto Oshima, Takashi Yukawa, Norio Saito, Aya Morinaga, Soichiro |
| description | Purpose
The C-reactive protein-albumin-lymphocyte (CALLY) index, which simultaneously evaluates the nutritional, immunological, and inflammatory statuses, is a new prognostic biomarker in patients with various cancers; however, no study has reported the clinical significance of the CALLY index in patients with pancreatic cancer. This study aimed to investigate whether the preoperative CALLY index is a prognostic biomarker in patients undergoing surgical resection of pancreatic cancer.
Methods
We retrospectively enrolled 461 patients with pancreatic cancer who underwent surgical resection between January 2013 and December 2022. The overall survival (OS) and relapse-free survival (RFS) rates were calculated using the Kaplan–Meier method. Univariate and multivariate analyses were performed using Cox proportional hazards regression models.
Results
The optimal cut-off value for the preoperative CALLY index was 1.9. In the low CALLY group, patients were older (
p
= 0.012), more patients underwent pancreaticoduodenectomy (
p
= 0.002), the median tumor size was larger (
p
|
| doi_str_mv | 10.1007/s00423-024-03512-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3118835151</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3118835151</sourcerecordid><originalsourceid>FETCH-LOGICAL-c228t-e0ed494923911a7c56294650e15d5dd094e88d700107da28a34351a67807a4833</originalsourceid><addsrcrecordid>eNp9UcmO1DAQjRCIGQZ-gAPycTgYyks6zhG1hkVqiQscOFlupzp4SOxgx4j-Hn6U6ukBceJUJdVb_Pya5rmAVwKge10AtFQcpOagWiG5edBcCq1aLnUrHv6zXzRPSrkFgE3X68fNheq1kiDgsvm1nUIM3k2sFjzUKWIpLB3Ylmd0fg0_kC05rRgid9O-zjSn47x8Tf64IrvevtntvrxkIQ74k7nC3Ak9xlTW4Nk-pNnlb5jpzha3BoxrYZWweUwhjqzUPN55ZyxIZimerBcXPZmfFDytmJ82jw5uKvjsfl41n9_efNq-57uP7z7QC7iX0qwcAQfd616qXgjX-XYje71pAUU7tMMAvUZjhg4odzc4aZyi7xFu0xnonDZKXTXXZ13K8L1iWe0cisdpchFTLVYJYQxRWkFQeYb6nErJeLBLDhT2aAXYUzn2XI6lcuxdOdYQ6cW9ft3POPyl_GmDAOoMKHSKI2Z7m2qOlPl_sr8B51eb6w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3118835151</pqid></control><display><type>article</type><title>Clinical usefulness of C-reactive protein-albumin-lymphocyte (CALLY) index as a prognostic biomarker in patients undergoing surgical resection of pancreatic cancer</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Kawahara, Shinnosuke ; Aoyama, Toru ; Murakawa, Masaaki ; Kanemoto, Rei ; Matsushita, Naohiko ; Hashimoto, Itaru ; Kamiya, Mariko ; Maezawa, Yukio ; Kobayashi, Satoshi ; Ueno, Makoto ; Yamamoto, Naoto ; Oshima, Takashi ; Yukawa, Norio ; Saito, Aya ; Morinaga, Soichiro</creator><creatorcontrib>Kawahara, Shinnosuke ; Aoyama, Toru ; Murakawa, Masaaki ; Kanemoto, Rei ; Matsushita, Naohiko ; Hashimoto, Itaru ; Kamiya, Mariko ; Maezawa, Yukio ; Kobayashi, Satoshi ; Ueno, Makoto ; Yamamoto, Naoto ; Oshima, Takashi ; Yukawa, Norio ; Saito, Aya ; Morinaga, Soichiro</creatorcontrib><description>Purpose
The C-reactive protein-albumin-lymphocyte (CALLY) index, which simultaneously evaluates the nutritional, immunological, and inflammatory statuses, is a new prognostic biomarker in patients with various cancers; however, no study has reported the clinical significance of the CALLY index in patients with pancreatic cancer. This study aimed to investigate whether the preoperative CALLY index is a prognostic biomarker in patients undergoing surgical resection of pancreatic cancer.
Methods
We retrospectively enrolled 461 patients with pancreatic cancer who underwent surgical resection between January 2013 and December 2022. The overall survival (OS) and relapse-free survival (RFS) rates were calculated using the Kaplan–Meier method. Univariate and multivariate analyses were performed using Cox proportional hazards regression models.
Results
The optimal cut-off value for the preoperative CALLY index was 1.9. In the low CALLY group, patients were older (
p
= 0.012), more patients underwent pancreaticoduodenectomy (
p
= 0.002), the median tumor size was larger (
p
< 0.001), more patients had pathologically confirmed metastatic lymph nodes (
p
= 0.015) and worse pathological stage (
p
= 0.015), and fewer patients received adjuvant chemotherapy (
p
= 0.003). A low CALLY index was associated with decreased OS (22.1
vs.
37.9 months) and RFS (12.4
vs.
16.4 months). Univariate and multivariate analyses showed that the preoperative CALLY index was an independent prognostic factor for OS (
p
< 0.001) and RFS (
p
= 0.045).
Conclusion
The preoperative CALLY index is a prognostic biomarker for both OS and RFS in patients undergoing surgery for pancreatic cancer.</description><identifier>ISSN: 1435-2451</identifier><identifier>EISSN: 1435-2451</identifier><identifier>DOI: 10.1007/s00423-024-03512-8</identifier><identifier>PMID: 39432010</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abdominal Surgery ; Aged ; Biomarkers, Tumor - blood ; C-Reactive Protein - analysis ; Cardiac Surgery ; Female ; General Surgery ; Humans ; Lymphocyte Count ; Lymphocytes ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Pancreatectomy ; Pancreatic Neoplasms - blood ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - surgery ; Pancreaticoduodenectomy ; Prognosis ; Retrospective Studies ; Serum Albumin - analysis ; Thoracic Surgery ; Traumatic Surgery ; Vascular Surgery</subject><ispartof>Langenbeck's archives of surgery, 2024-10, Vol.409 (1), p.317, Article 317</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c228t-e0ed494923911a7c56294650e15d5dd094e88d700107da28a34351a67807a4833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00423-024-03512-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00423-024-03512-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39432010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawahara, Shinnosuke</creatorcontrib><creatorcontrib>Aoyama, Toru</creatorcontrib><creatorcontrib>Murakawa, Masaaki</creatorcontrib><creatorcontrib>Kanemoto, Rei</creatorcontrib><creatorcontrib>Matsushita, Naohiko</creatorcontrib><creatorcontrib>Hashimoto, Itaru</creatorcontrib><creatorcontrib>Kamiya, Mariko</creatorcontrib><creatorcontrib>Maezawa, Yukio</creatorcontrib><creatorcontrib>Kobayashi, Satoshi</creatorcontrib><creatorcontrib>Ueno, Makoto</creatorcontrib><creatorcontrib>Yamamoto, Naoto</creatorcontrib><creatorcontrib>Oshima, Takashi</creatorcontrib><creatorcontrib>Yukawa, Norio</creatorcontrib><creatorcontrib>Saito, Aya</creatorcontrib><creatorcontrib>Morinaga, Soichiro</creatorcontrib><title>Clinical usefulness of C-reactive protein-albumin-lymphocyte (CALLY) index as a prognostic biomarker in patients undergoing surgical resection of pancreatic cancer</title><title>Langenbeck's archives of surgery</title><addtitle>Langenbecks Arch Surg</addtitle><addtitle>Langenbecks Arch Surg</addtitle><description>Purpose
The C-reactive protein-albumin-lymphocyte (CALLY) index, which simultaneously evaluates the nutritional, immunological, and inflammatory statuses, is a new prognostic biomarker in patients with various cancers; however, no study has reported the clinical significance of the CALLY index in patients with pancreatic cancer. This study aimed to investigate whether the preoperative CALLY index is a prognostic biomarker in patients undergoing surgical resection of pancreatic cancer.
Methods
We retrospectively enrolled 461 patients with pancreatic cancer who underwent surgical resection between January 2013 and December 2022. The overall survival (OS) and relapse-free survival (RFS) rates were calculated using the Kaplan–Meier method. Univariate and multivariate analyses were performed using Cox proportional hazards regression models.
Results
The optimal cut-off value for the preoperative CALLY index was 1.9. In the low CALLY group, patients were older (
p
= 0.012), more patients underwent pancreaticoduodenectomy (
p
= 0.002), the median tumor size was larger (
p
< 0.001), more patients had pathologically confirmed metastatic lymph nodes (
p
= 0.015) and worse pathological stage (
p
= 0.015), and fewer patients received adjuvant chemotherapy (
p
= 0.003). A low CALLY index was associated with decreased OS (22.1
vs.
37.9 months) and RFS (12.4
vs.
16.4 months). Univariate and multivariate analyses showed that the preoperative CALLY index was an independent prognostic factor for OS (
p
< 0.001) and RFS (
p
= 0.045).
Conclusion
The preoperative CALLY index is a prognostic biomarker for both OS and RFS in patients undergoing surgery for pancreatic cancer.</description><subject>Abdominal Surgery</subject><subject>Aged</subject><subject>Biomarkers, Tumor - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiac Surgery</subject><subject>Female</subject><subject>General Surgery</subject><subject>Humans</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Pancreatectomy</subject><subject>Pancreatic Neoplasms - blood</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Pancreaticoduodenectomy</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Serum Albumin - analysis</subject><subject>Thoracic Surgery</subject><subject>Traumatic Surgery</subject><subject>Vascular Surgery</subject><issn>1435-2451</issn><issn>1435-2451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcmO1DAQjRCIGQZ-gAPycTgYyks6zhG1hkVqiQscOFlupzp4SOxgx4j-Hn6U6ukBceJUJdVb_Pya5rmAVwKge10AtFQcpOagWiG5edBcCq1aLnUrHv6zXzRPSrkFgE3X68fNheq1kiDgsvm1nUIM3k2sFjzUKWIpLB3Ylmd0fg0_kC05rRgid9O-zjSn47x8Tf64IrvevtntvrxkIQ74k7nC3Ak9xlTW4Nk-pNnlb5jpzha3BoxrYZWweUwhjqzUPN55ZyxIZimerBcXPZmfFDytmJ82jw5uKvjsfl41n9_efNq-57uP7z7QC7iX0qwcAQfd616qXgjX-XYje71pAUU7tMMAvUZjhg4odzc4aZyi7xFu0xnonDZKXTXXZ13K8L1iWe0cisdpchFTLVYJYQxRWkFQeYb6nErJeLBLDhT2aAXYUzn2XI6lcuxdOdYQ6cW9ft3POPyl_GmDAOoMKHSKI2Z7m2qOlPl_sr8B51eb6w</recordid><startdate>20241021</startdate><enddate>20241021</enddate><creator>Kawahara, Shinnosuke</creator><creator>Aoyama, Toru</creator><creator>Murakawa, Masaaki</creator><creator>Kanemoto, Rei</creator><creator>Matsushita, Naohiko</creator><creator>Hashimoto, Itaru</creator><creator>Kamiya, Mariko</creator><creator>Maezawa, Yukio</creator><creator>Kobayashi, Satoshi</creator><creator>Ueno, Makoto</creator><creator>Yamamoto, Naoto</creator><creator>Oshima, Takashi</creator><creator>Yukawa, Norio</creator><creator>Saito, Aya</creator><creator>Morinaga, Soichiro</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241021</creationdate><title>Clinical usefulness of C-reactive protein-albumin-lymphocyte (CALLY) index as a prognostic biomarker in patients undergoing surgical resection of pancreatic cancer</title><author>Kawahara, Shinnosuke ; Aoyama, Toru ; Murakawa, Masaaki ; Kanemoto, Rei ; Matsushita, Naohiko ; Hashimoto, Itaru ; Kamiya, Mariko ; Maezawa, Yukio ; Kobayashi, Satoshi ; Ueno, Makoto ; Yamamoto, Naoto ; Oshima, Takashi ; Yukawa, Norio ; Saito, Aya ; Morinaga, Soichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-e0ed494923911a7c56294650e15d5dd094e88d700107da28a34351a67807a4833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abdominal Surgery</topic><topic>Aged</topic><topic>Biomarkers, Tumor - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiac Surgery</topic><topic>Female</topic><topic>General Surgery</topic><topic>Humans</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Pancreatectomy</topic><topic>Pancreatic Neoplasms - blood</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Pancreaticoduodenectomy</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Serum Albumin - analysis</topic><topic>Thoracic Surgery</topic><topic>Traumatic Surgery</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawahara, Shinnosuke</creatorcontrib><creatorcontrib>Aoyama, Toru</creatorcontrib><creatorcontrib>Murakawa, Masaaki</creatorcontrib><creatorcontrib>Kanemoto, Rei</creatorcontrib><creatorcontrib>Matsushita, Naohiko</creatorcontrib><creatorcontrib>Hashimoto, Itaru</creatorcontrib><creatorcontrib>Kamiya, Mariko</creatorcontrib><creatorcontrib>Maezawa, Yukio</creatorcontrib><creatorcontrib>Kobayashi, Satoshi</creatorcontrib><creatorcontrib>Ueno, Makoto</creatorcontrib><creatorcontrib>Yamamoto, Naoto</creatorcontrib><creatorcontrib>Oshima, Takashi</creatorcontrib><creatorcontrib>Yukawa, Norio</creatorcontrib><creatorcontrib>Saito, Aya</creatorcontrib><creatorcontrib>Morinaga, Soichiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langenbeck's archives of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawahara, Shinnosuke</au><au>Aoyama, Toru</au><au>Murakawa, Masaaki</au><au>Kanemoto, Rei</au><au>Matsushita, Naohiko</au><au>Hashimoto, Itaru</au><au>Kamiya, Mariko</au><au>Maezawa, Yukio</au><au>Kobayashi, Satoshi</au><au>Ueno, Makoto</au><au>Yamamoto, Naoto</au><au>Oshima, Takashi</au><au>Yukawa, Norio</au><au>Saito, Aya</au><au>Morinaga, Soichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical usefulness of C-reactive protein-albumin-lymphocyte (CALLY) index as a prognostic biomarker in patients undergoing surgical resection of pancreatic cancer</atitle><jtitle>Langenbeck's archives of surgery</jtitle><stitle>Langenbecks Arch Surg</stitle><addtitle>Langenbecks Arch Surg</addtitle><date>2024-10-21</date><risdate>2024</risdate><volume>409</volume><issue>1</issue><spage>317</spage><pages>317-</pages><artnum>317</artnum><issn>1435-2451</issn><eissn>1435-2451</eissn><abstract>Purpose
The C-reactive protein-albumin-lymphocyte (CALLY) index, which simultaneously evaluates the nutritional, immunological, and inflammatory statuses, is a new prognostic biomarker in patients with various cancers; however, no study has reported the clinical significance of the CALLY index in patients with pancreatic cancer. This study aimed to investigate whether the preoperative CALLY index is a prognostic biomarker in patients undergoing surgical resection of pancreatic cancer.
Methods
We retrospectively enrolled 461 patients with pancreatic cancer who underwent surgical resection between January 2013 and December 2022. The overall survival (OS) and relapse-free survival (RFS) rates were calculated using the Kaplan–Meier method. Univariate and multivariate analyses were performed using Cox proportional hazards regression models.
Results
The optimal cut-off value for the preoperative CALLY index was 1.9. In the low CALLY group, patients were older (
p
= 0.012), more patients underwent pancreaticoduodenectomy (
p
= 0.002), the median tumor size was larger (
p
< 0.001), more patients had pathologically confirmed metastatic lymph nodes (
p
= 0.015) and worse pathological stage (
p
= 0.015), and fewer patients received adjuvant chemotherapy (
p
= 0.003). A low CALLY index was associated with decreased OS (22.1
vs.
37.9 months) and RFS (12.4
vs.
16.4 months). Univariate and multivariate analyses showed that the preoperative CALLY index was an independent prognostic factor for OS (
p
< 0.001) and RFS (
p
= 0.045).
Conclusion
The preoperative CALLY index is a prognostic biomarker for both OS and RFS in patients undergoing surgery for pancreatic cancer.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39432010</pmid><doi>10.1007/s00423-024-03512-8</doi></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Abdominal Surgery Aged Biomarkers, Tumor - blood C-Reactive Protein - analysis Cardiac Surgery Female General Surgery Humans Lymphocyte Count Lymphocytes Male Medicine Medicine & Public Health Middle Aged Pancreatectomy Pancreatic Neoplasms - blood Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Pancreaticoduodenectomy Prognosis Retrospective Studies Serum Albumin - analysis Thoracic Surgery Traumatic Surgery Vascular Surgery |
| title | Clinical usefulness of C-reactive protein-albumin-lymphocyte (CALLY) index as a prognostic biomarker in patients undergoing surgical resection of pancreatic cancer |
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