Shaoyao decoction alleviates DSS-induced colitis by inhibiting IL-17a-mediated polarization of M1 macrophages

The efficacy of Shaoyao decoction (SYD), a traditional Chinese medicine prescription, in alleviating colonic mucosal inflammation in ulcerative colitis (UC) has been established. However, the specific mechanism underlying the therapeutic effects of SYD on UC is not clear. In this study, we demonstra...

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Veröffentlicht in:	Journal of ethnopharmacology 2025-01, Vol.337 (Pt 3), p.118941, Article 118941
Hauptverfasser:	Wang, Shiying, Cai, Linkun, Ma, Yanyan, Zhang, Haiyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Colitis - chemically induced Colitis - drug therapy Colitis, Ulcerative - chemically induced Colitis, Ulcerative - drug therapy Colon - drug effects Colon - metabolism Colon - pathology Cytokines - metabolism Dextran Sulfate Disease Models, Animal Drugs, Chinese Herbal - pharmacology IL-17a Interleukin-17 - metabolism M1 macrophage polarization Macrophages - drug effects Macrophages - metabolism Male Mice Mice, Inbred C57BL PPAR/NF-κB pathway RAW 264.7 Cells Shaoyao decoction Ulcerative colitis
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