Sirt1-mediated deacetylation of PGC-1α alleviated hepatic steatosis in type 2 diabetes mellitus via improving mitochondrial fatty acid oxidation

Being activated by deacetylation, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) has become an important regulator of metabolic-related diseases. The activation of Sirtuin 1 (Sirt1) by resveratrol was likely to deacetylate PGC-1α. However, the role of deacetylated PGC-1α in the...

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Veröffentlicht in:	Cellular signalling 2024-12, Vol.124, p.111478, Article 111478
Hauptverfasser:	Pang, Jiale, Yin, Longxiang, Jiang, Wenjie, Wang, Haiyan, Cheng, Qian, Jiang, Zhenzhou, Cao, Yanjuan, Zhu, Xia, Li, Baojing, Qian, Sitong, Yin, Xiaoxing, Wang, Tao, Lu, Qian, Yang, Tingting
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Fatty Acids - metabolism Fatty Liver - metabolism Fatty Liver - pathology Glucose - metabolism Hep G2 Cells Hepatocytes - metabolism Humans Mice Mitochondria - metabolism Mitochondrial FAO Oxidation-Reduction Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism PGC-1α deacetylation Sirt1 activation Sirtuin 1 - metabolism T2DM-associated FLD
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