Sarcopenia Influences Clinical Outcome in Hospitalized Patients with Peripheral Artery Disease Aged 75 Years and Older
Sarcopenia represents a relevant comorbidity in patients with peripheral artery disease (PAD). However, only few studies exist assessing the clinical burden of sarcopenia in PAD. All hospitalizations of patients aged ≥75 years who were admitted due to PAD within 2005–2020 in Germany were included in...
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| Veröffentlicht in: | Annals of vascular surgery 2025-01, Vol.110 (Pt B), p.54-65 |
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| creator | Schmitt, Volker H. Hobohm, Lukas Brochhausen, Christoph Espinola-Klein, Christine Lurz, Philipp Münzel, Thomas Hahad, Omar Keller, Karsten |
| description | Sarcopenia represents a relevant comorbidity in patients with peripheral artery disease (PAD). However, only few studies exist assessing the clinical burden of sarcopenia in PAD.
All hospitalizations of patients aged ≥75 years who were admitted due to PAD within 2005–2020 in Germany were included in the study and stratified for sarcopenia. Temporal trends and the impact of sarcopenia on treatment procedures as well as adverse in-hospital events were investigated.
Overall, 1,166,848 hospitalization cases of patients admitted due to PAD (median age 81.0 [78.0–85.0] years; 49.5% female sex) were included, of which 2,109 (0.2%) were coded with sarcopenia. Prevalence of sarcopenia in these patients increased during the observational period from 0.05% in 2005 to 0.34% in 2020 (β 2.61 [95%CI 2.42–2.80], P |
| doi_str_mv | 10.1016/j.avsg.2024.09.066 |
| format | Article |
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All hospitalizations of patients aged ≥75 years who were admitted due to PAD within 2005–2020 in Germany were included in the study and stratified for sarcopenia. Temporal trends and the impact of sarcopenia on treatment procedures as well as adverse in-hospital events were investigated.
Overall, 1,166,848 hospitalization cases of patients admitted due to PAD (median age 81.0 [78.0–85.0] years; 49.5% female sex) were included, of which 2,109 (0.2%) were coded with sarcopenia. Prevalence of sarcopenia in these patients increased during the observational period from 0.05% in 2005 to 0.34% in 2020 (β 2.61 [95%CI 2.42–2.80], P < 0.001). Sarcopenic PAD patients were more often female (52.1% vs. 49.5%, P = 0.015), obese (6.6% vs. 5.5%, P = 0.021), and revealed higher prevalences of comorbidities (Charlson comorbidity index, 7.00 [6.00–9.00] vs. 6.00 [5.00–7.00], P < 0.001). Sarcopenia was associated with reduced usage of reperfusion treatments (endovascular intervention: odds ratio (OR) 0.409 [95%CI 0.358–0.466], P < 0.001; surgical revascularization: OR 0.705 [95%CI 0.617–0.805], P < 0.001) but higher conduction of amputation (OR 1.365 [95%CI 1.231–1.514], P < 0.001) and higher rates of major adverse cardiovascular and cerebrovascular events (MACCE) (OR 1.313 [95%CI 1.141–1.512], P < 0.001) and in-hospital death (OR 1.229 [95%CI 1.052–1.436], P = 0.009).
Sarcopenia is an under-recognized condition in PAD patients of high clinical relevance causing a crucial disease burden. Awareness of the ailment needs to be increased in daily clinical practice to identify sarcopenia and improve the clinical outcome of this vulnerable patient group.
•Sarcopenia is an under-recognized condition in peripheral artery disease (PAD) patients, which was coded in only 0.2% of all PAD patients aged 75 years and older.•However, the awareness for sarcopenia increased slowly over time.•Sarcopenia was associated with an unbeneficial cardiovascular risk and comorbidity profile.•Interventional and surgical reperfusion treatments were less often performed in sarcopenic PAD patients and in return amputation was more often performed.•In PAD patients, sarcopenia was associated with an elevated length of in-hospital stay, higher rates of adverse in-hospital events, and increased in-hospital mortality.Why does this paper matter?•The results of our study underline the clinical impact of sarcopenia on outcomes in PAD patients.]]></description><identifier>ISSN: 0890-5096</identifier><identifier>ISSN: 1615-5947</identifier><identifier>EISSN: 1615-5947</identifier><identifier>DOI: 10.1016/j.avsg.2024.09.066</identifier><identifier>PMID: 39427977</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Amputation, Surgical ; Comorbidity ; Endovascular Procedures - adverse effects ; Endovascular Procedures - mortality ; Female ; Germany - epidemiology ; Hospital Mortality ; Hospitalization ; Humans ; Male ; Peripheral Arterial Disease - diagnosis ; Peripheral Arterial Disease - epidemiology ; Peripheral Arterial Disease - mortality ; Peripheral Arterial Disease - therapy ; Prevalence ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Sarcopenia - diagnosis ; Sarcopenia - epidemiology ; Sarcopenia - mortality ; Sarcopenia - therapy ; Time Factors ; Treatment Outcome ; Vascular Surgical Procedures - adverse effects ; Vascular Surgical Procedures - mortality</subject><ispartof>Annals of vascular surgery, 2025-01, Vol.110 (Pt B), p.54-65</ispartof><rights>2024 The Author(s)</rights><rights>Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c281t-d1906a6f60ce6362d38a727721b23587bbd73ef2422f0f7910875495ea6244823</cites><orcidid>0000-0002-0820-9584</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0890509624006629$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39427977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmitt, Volker H.</creatorcontrib><creatorcontrib>Hobohm, Lukas</creatorcontrib><creatorcontrib>Brochhausen, Christoph</creatorcontrib><creatorcontrib>Espinola-Klein, Christine</creatorcontrib><creatorcontrib>Lurz, Philipp</creatorcontrib><creatorcontrib>Münzel, Thomas</creatorcontrib><creatorcontrib>Hahad, Omar</creatorcontrib><creatorcontrib>Keller, Karsten</creatorcontrib><title>Sarcopenia Influences Clinical Outcome in Hospitalized Patients with Peripheral Artery Disease Aged 75 Years and Older</title><title>Annals of vascular surgery</title><addtitle>Ann Vasc Surg</addtitle><description><![CDATA[Sarcopenia represents a relevant comorbidity in patients with peripheral artery disease (PAD). However, only few studies exist assessing the clinical burden of sarcopenia in PAD.
All hospitalizations of patients aged ≥75 years who were admitted due to PAD within 2005–2020 in Germany were included in the study and stratified for sarcopenia. Temporal trends and the impact of sarcopenia on treatment procedures as well as adverse in-hospital events were investigated.
Overall, 1,166,848 hospitalization cases of patients admitted due to PAD (median age 81.0 [78.0–85.0] years; 49.5% female sex) were included, of which 2,109 (0.2%) were coded with sarcopenia. Prevalence of sarcopenia in these patients increased during the observational period from 0.05% in 2005 to 0.34% in 2020 (β 2.61 [95%CI 2.42–2.80], P < 0.001). Sarcopenic PAD patients were more often female (52.1% vs. 49.5%, P = 0.015), obese (6.6% vs. 5.5%, P = 0.021), and revealed higher prevalences of comorbidities (Charlson comorbidity index, 7.00 [6.00–9.00] vs. 6.00 [5.00–7.00], P < 0.001). Sarcopenia was associated with reduced usage of reperfusion treatments (endovascular intervention: odds ratio (OR) 0.409 [95%CI 0.358–0.466], P < 0.001; surgical revascularization: OR 0.705 [95%CI 0.617–0.805], P < 0.001) but higher conduction of amputation (OR 1.365 [95%CI 1.231–1.514], P < 0.001) and higher rates of major adverse cardiovascular and cerebrovascular events (MACCE) (OR 1.313 [95%CI 1.141–1.512], P < 0.001) and in-hospital death (OR 1.229 [95%CI 1.052–1.436], P = 0.009).
Sarcopenia is an under-recognized condition in PAD patients of high clinical relevance causing a crucial disease burden. Awareness of the ailment needs to be increased in daily clinical practice to identify sarcopenia and improve the clinical outcome of this vulnerable patient group.
•Sarcopenia is an under-recognized condition in peripheral artery disease (PAD) patients, which was coded in only 0.2% of all PAD patients aged 75 years and older.•However, the awareness for sarcopenia increased slowly over time.•Sarcopenia was associated with an unbeneficial cardiovascular risk and comorbidity profile.•Interventional and surgical reperfusion treatments were less often performed in sarcopenic PAD patients and in return amputation was more often performed.•In PAD patients, sarcopenia was associated with an elevated length of in-hospital stay, higher rates of adverse in-hospital events, and increased in-hospital mortality.Why does this paper matter?•The results of our study underline the clinical impact of sarcopenia on outcomes in PAD patients.]]></description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amputation, Surgical</subject><subject>Comorbidity</subject><subject>Endovascular Procedures - adverse effects</subject><subject>Endovascular Procedures - mortality</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Hospital Mortality</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Male</subject><subject>Peripheral Arterial Disease - diagnosis</subject><subject>Peripheral Arterial Disease - epidemiology</subject><subject>Peripheral Arterial Disease - mortality</subject><subject>Peripheral Arterial Disease - therapy</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sarcopenia - diagnosis</subject><subject>Sarcopenia - epidemiology</subject><subject>Sarcopenia - mortality</subject><subject>Sarcopenia - therapy</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vascular Surgical Procedures - adverse effects</subject><subject>Vascular Surgical Procedures - mortality</subject><issn>0890-5096</issn><issn>1615-5947</issn><issn>1615-5947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1O3DAURq2KqkxpX4AF8pJNUv_FP1I3o4EWJKRBarvoyvLYN-BRJkltB0SfhmfhyZrR0C67upvzHekehE4pqSmh8tO2dg_5rmaEiZqYmkj5Bi2opE3VGKGO0IJoQ6qGGHmM3ue8JYQyLfQ7dMyNYMootUCP31zywwh9dPi6b7sJeg8Zr7rYR-86vJ6KH3aAY4-vhjzG4rr4GwK-dSVCXzJ-jOUe30KK4z2kebBMBdITvogZXAa8vJth1bw8_wSXMnZ9wOsuQPqA3rauy_Dx9Z6gH18uv6-uqpv11-vV8qbyTNNSBWqIdLKVxIPkkgWunWJKMbphvNFqswmKQ8sEYy1plaFEq0aYBpxkQmjGT9D5wTum4dcEudhdzB66zvUwTNlySrXmgisxo-yA-jTknKC1Y4o7l54sJXYf3G7tPrjdB7fE2Dn4PDp79U-bHYR_k7-FZ-DzAYD5y4cIyWYf95FDTOCLDUP8n_8Ph1OSNQ</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Schmitt, Volker H.</creator><creator>Hobohm, Lukas</creator><creator>Brochhausen, Christoph</creator><creator>Espinola-Klein, Christine</creator><creator>Lurz, Philipp</creator><creator>Münzel, Thomas</creator><creator>Hahad, Omar</creator><creator>Keller, Karsten</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0820-9584</orcidid></search><sort><creationdate>202501</creationdate><title>Sarcopenia Influences Clinical Outcome in Hospitalized Patients with Peripheral Artery Disease Aged 75 Years and Older</title><author>Schmitt, Volker H. ; Hobohm, Lukas ; Brochhausen, Christoph ; Espinola-Klein, Christine ; Lurz, Philipp ; Münzel, Thomas ; Hahad, Omar ; Keller, Karsten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-d1906a6f60ce6362d38a727721b23587bbd73ef2422f0f7910875495ea6244823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amputation, Surgical</topic><topic>Comorbidity</topic><topic>Endovascular Procedures - adverse effects</topic><topic>Endovascular Procedures - mortality</topic><topic>Female</topic><topic>Germany - epidemiology</topic><topic>Hospital Mortality</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Male</topic><topic>Peripheral Arterial Disease - diagnosis</topic><topic>Peripheral Arterial Disease - epidemiology</topic><topic>Peripheral Arterial Disease - mortality</topic><topic>Peripheral Arterial Disease - therapy</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Sarcopenia - diagnosis</topic><topic>Sarcopenia - epidemiology</topic><topic>Sarcopenia - mortality</topic><topic>Sarcopenia - therapy</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vascular Surgical Procedures - adverse effects</topic><topic>Vascular Surgical Procedures - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmitt, Volker H.</creatorcontrib><creatorcontrib>Hobohm, Lukas</creatorcontrib><creatorcontrib>Brochhausen, Christoph</creatorcontrib><creatorcontrib>Espinola-Klein, Christine</creatorcontrib><creatorcontrib>Lurz, Philipp</creatorcontrib><creatorcontrib>Münzel, Thomas</creatorcontrib><creatorcontrib>Hahad, Omar</creatorcontrib><creatorcontrib>Keller, Karsten</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of vascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmitt, Volker H.</au><au>Hobohm, Lukas</au><au>Brochhausen, Christoph</au><au>Espinola-Klein, Christine</au><au>Lurz, Philipp</au><au>Münzel, Thomas</au><au>Hahad, Omar</au><au>Keller, Karsten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sarcopenia Influences Clinical Outcome in Hospitalized Patients with Peripheral Artery Disease Aged 75 Years and Older</atitle><jtitle>Annals of vascular surgery</jtitle><addtitle>Ann Vasc Surg</addtitle><date>2025-01</date><risdate>2025</risdate><volume>110</volume><issue>Pt B</issue><spage>54</spage><epage>65</epage><pages>54-65</pages><issn>0890-5096</issn><issn>1615-5947</issn><eissn>1615-5947</eissn><abstract><![CDATA[Sarcopenia represents a relevant comorbidity in patients with peripheral artery disease (PAD). However, only few studies exist assessing the clinical burden of sarcopenia in PAD.
All hospitalizations of patients aged ≥75 years who were admitted due to PAD within 2005–2020 in Germany were included in the study and stratified for sarcopenia. Temporal trends and the impact of sarcopenia on treatment procedures as well as adverse in-hospital events were investigated.
Overall, 1,166,848 hospitalization cases of patients admitted due to PAD (median age 81.0 [78.0–85.0] years; 49.5% female sex) were included, of which 2,109 (0.2%) were coded with sarcopenia. Prevalence of sarcopenia in these patients increased during the observational period from 0.05% in 2005 to 0.34% in 2020 (β 2.61 [95%CI 2.42–2.80], P < 0.001). Sarcopenic PAD patients were more often female (52.1% vs. 49.5%, P = 0.015), obese (6.6% vs. 5.5%, P = 0.021), and revealed higher prevalences of comorbidities (Charlson comorbidity index, 7.00 [6.00–9.00] vs. 6.00 [5.00–7.00], P < 0.001). Sarcopenia was associated with reduced usage of reperfusion treatments (endovascular intervention: odds ratio (OR) 0.409 [95%CI 0.358–0.466], P < 0.001; surgical revascularization: OR 0.705 [95%CI 0.617–0.805], P < 0.001) but higher conduction of amputation (OR 1.365 [95%CI 1.231–1.514], P < 0.001) and higher rates of major adverse cardiovascular and cerebrovascular events (MACCE) (OR 1.313 [95%CI 1.141–1.512], P < 0.001) and in-hospital death (OR 1.229 [95%CI 1.052–1.436], P = 0.009).
Sarcopenia is an under-recognized condition in PAD patients of high clinical relevance causing a crucial disease burden. Awareness of the ailment needs to be increased in daily clinical practice to identify sarcopenia and improve the clinical outcome of this vulnerable patient group.
•Sarcopenia is an under-recognized condition in peripheral artery disease (PAD) patients, which was coded in only 0.2% of all PAD patients aged 75 years and older.•However, the awareness for sarcopenia increased slowly over time.•Sarcopenia was associated with an unbeneficial cardiovascular risk and comorbidity profile.•Interventional and surgical reperfusion treatments were less often performed in sarcopenic PAD patients and in return amputation was more often performed.•In PAD patients, sarcopenia was associated with an elevated length of in-hospital stay, higher rates of adverse in-hospital events, and increased in-hospital mortality.Why does this paper matter?•The results of our study underline the clinical impact of sarcopenia on outcomes in PAD patients.]]></abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>39427977</pmid><doi>10.1016/j.avsg.2024.09.066</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-0820-9584</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Aged Aged, 80 and over Amputation, Surgical Comorbidity Endovascular Procedures - adverse effects Endovascular Procedures - mortality Female Germany - epidemiology Hospital Mortality Hospitalization Humans Male Peripheral Arterial Disease - diagnosis Peripheral Arterial Disease - epidemiology Peripheral Arterial Disease - mortality Peripheral Arterial Disease - therapy Prevalence Retrospective Studies Risk Assessment Risk Factors Sarcopenia - diagnosis Sarcopenia - epidemiology Sarcopenia - mortality Sarcopenia - therapy Time Factors Treatment Outcome Vascular Surgical Procedures - adverse effects Vascular Surgical Procedures - mortality |
| title | Sarcopenia Influences Clinical Outcome in Hospitalized Patients with Peripheral Artery Disease Aged 75 Years and Older |
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