Ex vivo permeability study of poorly soluble drugs across gastrointestinal membranes: acceptor compartment media composition

[Display omitted] •Acceptor compartment media compositions in ex vivo permeability studies for poorly soluble drugs are critically evaluated•An algorithm for selecting solubility-enhancing additives for the acceptor media in ex vivo permeability studies is proposed•The acceptor media components sele...

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Veröffentlicht in:	Drug discovery today 2024-12, Vol.29 (12), p.104214, Article 104214
Hauptverfasser:	Sitovs, Andrejs, Mohylyuk, Valentyn
Format:	Artikel
Sprache:	eng
Schlagworte:	acceptor Animals Drug Delivery Systems ex vivo Gastrointestinal Tract - metabolism Humans Intestinal Absorption Permeability Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism poorly soluble drugs Solubility Ussing chamber
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