CRISPR innovations in tissue engineering and gene editing

The CRISPR/Cas9 system is a powerful tool for genome editing, utilizing the Cas9 nuclease and programmable single guide RNA (sgRNA). However, the Cas9 nuclease activity can be disabled by mutation, resulting in catalytically deactivated Cas9 (dCas9). By combining the customizable sgRNA with dCas9, r...

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Veröffentlicht in:	Life sciences (1973) 2024-12, Vol.358, p.123120, Article 123120
Hauptverfasser:	Razavi, ZahraSadat, Soltani, Madjid, Souri, Mohammad, van Wijnen, Andre J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Clustered Regularly Interspaced Short Palindromic Repeats - genetics CRISPR system CRISPR-Cas Systems Gene Editing - methods Genome editing Humans Regenerative medicine Regenerative Medicine - methods Stem cell engineering Tissue Engineering - methods
Online-Zugang:	Volltext
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