A Systematic Review on the Role of Neutrophil to Lymphocyte Ratio in Limb Ischemia
Limb ischemia is a severe vascular condition that can lead to critical complications, endangering both limbs and lives. The goal of this research was to explore the role of neutrophil to lymphocyte ratio (NLR) in limb ischemia. From inception to June 8, 2022, PubMed/MEDLINE, Institute for Scientific...
Gespeichert in:
| Veröffentlicht in: | Annals of vascular surgery 2025-02, Vol.111, p.1-12 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 12 |
|---|---|
| container_issue | |
| container_start_page | 1 |
| container_title | Annals of vascular surgery |
| container_volume | 111 |
| creator | Khanzadeh, Monireh Babadi, Saghar Ghaedi, Arshin Meidani, Fatemeh Zari Rahmati, Rahem Aminizadeh, Sarina Bazrafshan drissi, Hamed Yaghoobpoor, Shirin Ghanbari Boroujeni, Mohammad Reza Khanzadeh, Shokoufeh |
| description | Limb ischemia is a severe vascular condition that can lead to critical complications, endangering both limbs and lives. The goal of this research was to explore the role of neutrophil to lymphocyte ratio (NLR) in limb ischemia.
From inception to June 8, 2022, PubMed/MEDLINE, Institute for Scientific Information Web of Science, and Scopus were searched for articles comparing NLR in limb ischemia to healthy individuals.
Finally, a total of 23 studies were included in the review. There was a direct link between NLR and critical limb ischemia (CLI) development in peripheral arterial disease patients. Elevated NLR levels predict a higher risk of CLI among peripheral arterial disease patients. Also, it was concluded that NLR is a dependable predictor of survival in patients with limb ischemia, and higher NLR readings are linked to decreased survival rates. Moreover, the risk of amputation is related to the level of NLR in CLI patients. However, based on the data, NLR is not a reliable indicator of sarcopenia in CLI patients. More research is needed to determine the relationship between NLR and response to treatment in CLI patients. Also, we recommend investigating the effect of each treatment on NLR level in these patients.
Our results provide evidence that NLR level is associated with risk of amputation and mortality in patients with limb ischemia. It is a promising biomarker that can be easily incorporated into clinical practice to assist in the prediction and prevention of CLI. |
| doi_str_mv | 10.1016/j.avsg.2024.09.065 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3118470700</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0890509624006630</els_id><sourcerecordid>3118470700</sourcerecordid><originalsourceid>FETCH-LOGICAL-c237t-61647c79d205bac98eaec15b4192687fd5216aca7ce8d1f5479193f840cd63793</originalsourceid><addsrcrecordid>eNp9kDtPwzAURi0EgvL4AwzII0vCtePYscSCEC-pAqnAbLnODXWV1CV2i_rvSVVgZLrL-Y50DyHnDHIGTF7Nc7uOHzkHLnLQOchyj4yYZGVWaqH2yQgqDVkJWh6R4xjnAIxXojokR4UWXEolRmRyQ183MWFnk3d0gmuPXzQsaJohnYQWaWjoM65SH5Yz39IU6HjTLWfBbdIADKNA_YKOfTelT9HNsPP2lBw0to149nNPyPv93dvtYzZ-eXi6vRlnjhcqZZJJoZzSNYdyap2u0KJj5VQwzWWlmrrkTFpnlcOqZk0plGa6aCoBrpaF0sUJudx5l334XGFMpvPRYdvaBYZVNAVjlVCgAAaU71DXhxh7bMyy953tN4aB2bY0c7NtabYtDWgztBxGFz_-1bTD-m_yG28ArncADl8O4XoTnceFw9r36JKpg__P_w1uWIRn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3118470700</pqid></control><display><type>article</type><title>A Systematic Review on the Role of Neutrophil to Lymphocyte Ratio in Limb Ischemia</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Khanzadeh, Monireh ; Babadi, Saghar ; Ghaedi, Arshin ; Meidani, Fatemeh Zari ; Rahmati, Rahem ; Aminizadeh, Sarina ; Bazrafshan drissi, Hamed ; Yaghoobpoor, Shirin ; Ghanbari Boroujeni, Mohammad Reza ; Khanzadeh, Shokoufeh</creator><creatorcontrib>Khanzadeh, Monireh ; Babadi, Saghar ; Ghaedi, Arshin ; Meidani, Fatemeh Zari ; Rahmati, Rahem ; Aminizadeh, Sarina ; Bazrafshan drissi, Hamed ; Yaghoobpoor, Shirin ; Ghanbari Boroujeni, Mohammad Reza ; Khanzadeh, Shokoufeh</creatorcontrib><description>Limb ischemia is a severe vascular condition that can lead to critical complications, endangering both limbs and lives. The goal of this research was to explore the role of neutrophil to lymphocyte ratio (NLR) in limb ischemia.
From inception to June 8, 2022, PubMed/MEDLINE, Institute for Scientific Information Web of Science, and Scopus were searched for articles comparing NLR in limb ischemia to healthy individuals.
Finally, a total of 23 studies were included in the review. There was a direct link between NLR and critical limb ischemia (CLI) development in peripheral arterial disease patients. Elevated NLR levels predict a higher risk of CLI among peripheral arterial disease patients. Also, it was concluded that NLR is a dependable predictor of survival in patients with limb ischemia, and higher NLR readings are linked to decreased survival rates. Moreover, the risk of amputation is related to the level of NLR in CLI patients. However, based on the data, NLR is not a reliable indicator of sarcopenia in CLI patients. More research is needed to determine the relationship between NLR and response to treatment in CLI patients. Also, we recommend investigating the effect of each treatment on NLR level in these patients.
Our results provide evidence that NLR level is associated with risk of amputation and mortality in patients with limb ischemia. It is a promising biomarker that can be easily incorporated into clinical practice to assist in the prediction and prevention of CLI.</description><identifier>ISSN: 0890-5096</identifier><identifier>ISSN: 1615-5947</identifier><identifier>EISSN: 1615-5947</identifier><identifier>DOI: 10.1016/j.avsg.2024.09.065</identifier><identifier>PMID: 39426674</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Amputation, Surgical ; Female ; Humans ; Ischemia - blood ; Ischemia - diagnosis ; Ischemia - mortality ; Ischemia - physiopathology ; Limb Salvage ; Lymphocyte Count ; Lymphocytes ; Male ; Middle Aged ; Neutrophils ; Peripheral Arterial Disease - blood ; Peripheral Arterial Disease - diagnosis ; Peripheral Arterial Disease - immunology ; Peripheral Arterial Disease - mortality ; Predictive Value of Tests ; Prognosis ; Risk Assessment ; Risk Factors</subject><ispartof>Annals of vascular surgery, 2025-02, Vol.111, p.1-12</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c237t-61647c79d205bac98eaec15b4192687fd5216aca7ce8d1f5479193f840cd63793</cites><orcidid>0000-0002-4177-8746</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0890509624006630$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39426674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khanzadeh, Monireh</creatorcontrib><creatorcontrib>Babadi, Saghar</creatorcontrib><creatorcontrib>Ghaedi, Arshin</creatorcontrib><creatorcontrib>Meidani, Fatemeh Zari</creatorcontrib><creatorcontrib>Rahmati, Rahem</creatorcontrib><creatorcontrib>Aminizadeh, Sarina</creatorcontrib><creatorcontrib>Bazrafshan drissi, Hamed</creatorcontrib><creatorcontrib>Yaghoobpoor, Shirin</creatorcontrib><creatorcontrib>Ghanbari Boroujeni, Mohammad Reza</creatorcontrib><creatorcontrib>Khanzadeh, Shokoufeh</creatorcontrib><title>A Systematic Review on the Role of Neutrophil to Lymphocyte Ratio in Limb Ischemia</title><title>Annals of vascular surgery</title><addtitle>Ann Vasc Surg</addtitle><description>Limb ischemia is a severe vascular condition that can lead to critical complications, endangering both limbs and lives. The goal of this research was to explore the role of neutrophil to lymphocyte ratio (NLR) in limb ischemia.
From inception to June 8, 2022, PubMed/MEDLINE, Institute for Scientific Information Web of Science, and Scopus were searched for articles comparing NLR in limb ischemia to healthy individuals.
Finally, a total of 23 studies were included in the review. There was a direct link between NLR and critical limb ischemia (CLI) development in peripheral arterial disease patients. Elevated NLR levels predict a higher risk of CLI among peripheral arterial disease patients. Also, it was concluded that NLR is a dependable predictor of survival in patients with limb ischemia, and higher NLR readings are linked to decreased survival rates. Moreover, the risk of amputation is related to the level of NLR in CLI patients. However, based on the data, NLR is not a reliable indicator of sarcopenia in CLI patients. More research is needed to determine the relationship between NLR and response to treatment in CLI patients. Also, we recommend investigating the effect of each treatment on NLR level in these patients.
Our results provide evidence that NLR level is associated with risk of amputation and mortality in patients with limb ischemia. It is a promising biomarker that can be easily incorporated into clinical practice to assist in the prediction and prevention of CLI.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amputation, Surgical</subject><subject>Female</subject><subject>Humans</subject><subject>Ischemia - blood</subject><subject>Ischemia - diagnosis</subject><subject>Ischemia - mortality</subject><subject>Ischemia - physiopathology</subject><subject>Limb Salvage</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neutrophils</subject><subject>Peripheral Arterial Disease - blood</subject><subject>Peripheral Arterial Disease - diagnosis</subject><subject>Peripheral Arterial Disease - immunology</subject><subject>Peripheral Arterial Disease - mortality</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><issn>0890-5096</issn><issn>1615-5947</issn><issn>1615-5947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAURi0EgvL4AwzII0vCtePYscSCEC-pAqnAbLnODXWV1CV2i_rvSVVgZLrL-Y50DyHnDHIGTF7Nc7uOHzkHLnLQOchyj4yYZGVWaqH2yQgqDVkJWh6R4xjnAIxXojokR4UWXEolRmRyQ183MWFnk3d0gmuPXzQsaJohnYQWaWjoM65SH5Yz39IU6HjTLWfBbdIADKNA_YKOfTelT9HNsPP2lBw0to149nNPyPv93dvtYzZ-eXi6vRlnjhcqZZJJoZzSNYdyap2u0KJj5VQwzWWlmrrkTFpnlcOqZk0plGa6aCoBrpaF0sUJudx5l334XGFMpvPRYdvaBYZVNAVjlVCgAAaU71DXhxh7bMyy953tN4aB2bY0c7NtabYtDWgztBxGFz_-1bTD-m_yG28ArncADl8O4XoTnceFw9r36JKpg__P_w1uWIRn</recordid><startdate>20250201</startdate><enddate>20250201</enddate><creator>Khanzadeh, Monireh</creator><creator>Babadi, Saghar</creator><creator>Ghaedi, Arshin</creator><creator>Meidani, Fatemeh Zari</creator><creator>Rahmati, Rahem</creator><creator>Aminizadeh, Sarina</creator><creator>Bazrafshan drissi, Hamed</creator><creator>Yaghoobpoor, Shirin</creator><creator>Ghanbari Boroujeni, Mohammad Reza</creator><creator>Khanzadeh, Shokoufeh</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4177-8746</orcidid></search><sort><creationdate>20250201</creationdate><title>A Systematic Review on the Role of Neutrophil to Lymphocyte Ratio in Limb Ischemia</title><author>Khanzadeh, Monireh ; Babadi, Saghar ; Ghaedi, Arshin ; Meidani, Fatemeh Zari ; Rahmati, Rahem ; Aminizadeh, Sarina ; Bazrafshan drissi, Hamed ; Yaghoobpoor, Shirin ; Ghanbari Boroujeni, Mohammad Reza ; Khanzadeh, Shokoufeh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c237t-61647c79d205bac98eaec15b4192687fd5216aca7ce8d1f5479193f840cd63793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amputation, Surgical</topic><topic>Female</topic><topic>Humans</topic><topic>Ischemia - blood</topic><topic>Ischemia - diagnosis</topic><topic>Ischemia - mortality</topic><topic>Ischemia - physiopathology</topic><topic>Limb Salvage</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neutrophils</topic><topic>Peripheral Arterial Disease - blood</topic><topic>Peripheral Arterial Disease - diagnosis</topic><topic>Peripheral Arterial Disease - immunology</topic><topic>Peripheral Arterial Disease - mortality</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khanzadeh, Monireh</creatorcontrib><creatorcontrib>Babadi, Saghar</creatorcontrib><creatorcontrib>Ghaedi, Arshin</creatorcontrib><creatorcontrib>Meidani, Fatemeh Zari</creatorcontrib><creatorcontrib>Rahmati, Rahem</creatorcontrib><creatorcontrib>Aminizadeh, Sarina</creatorcontrib><creatorcontrib>Bazrafshan drissi, Hamed</creatorcontrib><creatorcontrib>Yaghoobpoor, Shirin</creatorcontrib><creatorcontrib>Ghanbari Boroujeni, Mohammad Reza</creatorcontrib><creatorcontrib>Khanzadeh, Shokoufeh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of vascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khanzadeh, Monireh</au><au>Babadi, Saghar</au><au>Ghaedi, Arshin</au><au>Meidani, Fatemeh Zari</au><au>Rahmati, Rahem</au><au>Aminizadeh, Sarina</au><au>Bazrafshan drissi, Hamed</au><au>Yaghoobpoor, Shirin</au><au>Ghanbari Boroujeni, Mohammad Reza</au><au>Khanzadeh, Shokoufeh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Systematic Review on the Role of Neutrophil to Lymphocyte Ratio in Limb Ischemia</atitle><jtitle>Annals of vascular surgery</jtitle><addtitle>Ann Vasc Surg</addtitle><date>2025-02-01</date><risdate>2025</risdate><volume>111</volume><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>0890-5096</issn><issn>1615-5947</issn><eissn>1615-5947</eissn><abstract>Limb ischemia is a severe vascular condition that can lead to critical complications, endangering both limbs and lives. The goal of this research was to explore the role of neutrophil to lymphocyte ratio (NLR) in limb ischemia.
From inception to June 8, 2022, PubMed/MEDLINE, Institute for Scientific Information Web of Science, and Scopus were searched for articles comparing NLR in limb ischemia to healthy individuals.
Finally, a total of 23 studies were included in the review. There was a direct link between NLR and critical limb ischemia (CLI) development in peripheral arterial disease patients. Elevated NLR levels predict a higher risk of CLI among peripheral arterial disease patients. Also, it was concluded that NLR is a dependable predictor of survival in patients with limb ischemia, and higher NLR readings are linked to decreased survival rates. Moreover, the risk of amputation is related to the level of NLR in CLI patients. However, based on the data, NLR is not a reliable indicator of sarcopenia in CLI patients. More research is needed to determine the relationship between NLR and response to treatment in CLI patients. Also, we recommend investigating the effect of each treatment on NLR level in these patients.
Our results provide evidence that NLR level is associated with risk of amputation and mortality in patients with limb ischemia. It is a promising biomarker that can be easily incorporated into clinical practice to assist in the prediction and prevention of CLI.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>39426674</pmid><doi>10.1016/j.avsg.2024.09.065</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-4177-8746</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0890-5096 |
| ispartof | Annals of vascular surgery, 2025-02, Vol.111, p.1-12 |
| issn | 0890-5096 1615-5947 1615-5947 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3118470700 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Aged, 80 and over Amputation, Surgical Female Humans Ischemia - blood Ischemia - diagnosis Ischemia - mortality Ischemia - physiopathology Limb Salvage Lymphocyte Count Lymphocytes Male Middle Aged Neutrophils Peripheral Arterial Disease - blood Peripheral Arterial Disease - diagnosis Peripheral Arterial Disease - immunology Peripheral Arterial Disease - mortality Predictive Value of Tests Prognosis Risk Assessment Risk Factors |
| title | A Systematic Review on the Role of Neutrophil to Lymphocyte Ratio in Limb Ischemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T21%3A13%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Systematic%20Review%20on%20the%20Role%20of%20Neutrophil%20to%20Lymphocyte%20Ratio%20in%20Limb%20Ischemia&rft.jtitle=Annals%20of%20vascular%20surgery&rft.au=Khanzadeh,%20Monireh&rft.date=2025-02-01&rft.volume=111&rft.spage=1&rft.epage=12&rft.pages=1-12&rft.issn=0890-5096&rft.eissn=1615-5947&rft_id=info:doi/10.1016/j.avsg.2024.09.065&rft_dat=%3Cproquest_cross%3E3118470700%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3118470700&rft_id=info:pmid/39426674&rft_els_id=S0890509624006630&rfr_iscdi=true |