SIRT2 deacetylates and decreases the expression of FOXM1 in colon cancer

New FOXM1‐specific inhibitors with the potential to be used for therapeutic purposes are under extensive research. We hypothesized that deacetylation of FOXM1 would decrease protein expression, thus providing novel therapeutic management of colon cancers. Immunostaining was used to determine FOXM1 a...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2024-11, Vol.38 (11), p.e70018-n/a
Hauptverfasser:	Yildiz, Baris, Demirel, Ramazan, Staudacher, Jonas J., Beseren, Hatice, Yildiz, Gulden, Akpinar, Ali Emre, Park, Seong‐Hoon, Ozden, Ozkan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Berberine Colon Colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer Colorectal carcinoma CRC Deacetylation Disease management Female Forkhead Box Protein M1 - genetics Forkhead Box Protein M1 - metabolism FOXM1 Gene Expression Regulation, Neoplastic - drug effects HCT116 Cells Histones Humans Immunomodulation Immunoprecipitation Inhibitors Male Molecular interactions posttranslational regulation Quercetin Resveratrol SirReal2 sirtuin Sirtuin 2 - genetics Sirtuin 2 - metabolism Staining Therapeutic applications Tumor cell lines
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