Mammographic density and breast cancer risk among Black American women

Mammographic density and breast cancer risk among Black American women

High mammographic density is a well-established risk factor for breast cancer; however, data from Black women are limited. It is largely unknown how mammographic density is associated with breast cancer subtypes among Black women. We examined the association between percent mammographic density (PMD...

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Veröffentlicht in:International journal of cancer 2024-10
Hauptverfasser: Holder, Etienne X, Bigham, Zahna, Nelson, Kerrie P, Barnard, Mollie E, Palmer, Julie R, Bertrand, Kimberly A
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container_title International journal of cancer
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creator Holder, Etienne X
Bigham, Zahna
Nelson, Kerrie P
Barnard, Mollie E
Palmer, Julie R
Bertrand, Kimberly A
description High mammographic density is a well-established risk factor for breast cancer; however, data from Black women are limited. It is largely unknown how mammographic density is associated with breast cancer subtypes among Black women. We examined the association between percent mammographic density (PMD) and breast cancer risk among participants in the Black Women's Health Study. Digital screening mammograms were available for 363 cases and 5541 non-cases. Cumulus software was used to assess PMD. We used inverse probability of sampling weights and Cox proportional hazards models, adjusted for age and body mass index, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) overall and by age at mammography and estrogen receptor (ER) status of the breast tumors. Multivariable models included additional breast cancer risk factors. Tests of statistical significance were 2-sided. In simple models, women in the highest quartile of PMD had 53% increased odds of breast cancer compared to those in the lowest quartile (HR 1.53; 95% CI: 1.11, 2.11). HRs were 1.37 (95% CI: 0.83, 2.24) among women
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HRs were 1.37 (95% CI: 0.83, 2.24) among women &lt;55 years of age and 1.68 (95% CI: 1.10, 2.56) among women aged ≥55 years. HRs were 1.49 (95% CI: 1.02, 2.16) for ER+ cancer and 1.45 (95% CI: 0.73, 2.87) for ER- cancer. Associations were largely unchanged in multivariable models. In this study of U.S. Black women, higher PMD was associated with ER+ and ER- breast cancer risk. 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title Mammographic density and breast cancer risk among Black American women
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