The Society of Thoracic Surgeons Expert Consensus on the Multidisciplinary Management and Resectability of Locally Advanced Non-small Cell Lung Cancer
The contemporary management and resectability of locally advanced lung cancer are undergoing significant changes as new data emerge regarding immunotherapy and targeted treatments. The objective of this document is to review the literature and present consensus among a group of multidisciplinary exp...
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| Veröffentlicht in: | The Annals of thoracic surgery 2025-01, Vol.119 (1), p.16-33 |
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| creator | Kim, Samuel S. Cooke, David T. Kidane, Biniam Tapias, Luis F. Lazar, John F. Awori Hayanga, Jeremiah W. Patel, Jyoti D. Neal, Joel W. Abazeed, Mohamed E. Willers, Henning Shrager, Joseph B. |
| description | The contemporary management and resectability of locally advanced lung cancer are undergoing significant changes as new data emerge regarding immunotherapy and targeted treatments. The objective of this document is to review the literature and present consensus among a group of multidisciplinary experts to guide the determination of resectability and management of locally advanced non-small cell lung cancer (NSCLC) in the context of contemporary evidence.
The Society of Thoracic Surgeon Workforce on Thoracic Surgery assembled a multidisciplinary expert panel composed of thoracic surgeons and medical and radiation oncologists with established expertise in the management of lung cancer. A focused literature review was performed, and expert consensus statements were developed using a modified Delphi process to address 3 major themes: (1) assessing resectability and multidisciplinary management of locally advanced lung cancer, (2) neoadjuvant (including perioperative) therapy, and (3) adjuvant therapy.
A consensus was reached on 19 recommendations. These consensus statements reflect updated insights on resectability and multidisciplinary management of locally advanced lung cancer based on the latest literature and current clinical experience, mainly focusing on the appropriateness of surgical therapy and emerging data regarding neoadjuvant and adjuvant therapies.
Despite the complex decision-making process in managing locally advanced lung cancer, this expert panel agreed on several key recommendations. This document provides guidance for thoracic surgeons and other medical professionals in the optimal management of locally advanced lung cancer based on the most updated evidence and literature. |
| doi_str_mv | 10.1016/j.athoracsur.2024.09.041 |
| format | Article |
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The Society of Thoracic Surgeon Workforce on Thoracic Surgery assembled a multidisciplinary expert panel composed of thoracic surgeons and medical and radiation oncologists with established expertise in the management of lung cancer. A focused literature review was performed, and expert consensus statements were developed using a modified Delphi process to address 3 major themes: (1) assessing resectability and multidisciplinary management of locally advanced lung cancer, (2) neoadjuvant (including perioperative) therapy, and (3) adjuvant therapy.
A consensus was reached on 19 recommendations. These consensus statements reflect updated insights on resectability and multidisciplinary management of locally advanced lung cancer based on the latest literature and current clinical experience, mainly focusing on the appropriateness of surgical therapy and emerging data regarding neoadjuvant and adjuvant therapies.
Despite the complex decision-making process in managing locally advanced lung cancer, this expert panel agreed on several key recommendations. This document provides guidance for thoracic surgeons and other medical professionals in the optimal management of locally advanced lung cancer based on the most updated evidence and literature.</description><identifier>ISSN: 0003-4975</identifier><identifier>ISSN: 1552-6259</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/j.athoracsur.2024.09.041</identifier><identifier>PMID: 39424119</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Non-Small-Cell Lung - therapy ; Combined Modality Therapy - methods ; Combined Modality Therapy - standards ; Consensus ; Humans ; Lung Neoplasms - pathology ; Lung Neoplasms - therapy ; Neoadjuvant Therapy - methods ; Neoadjuvant Therapy - standards ; Neoplasm Staging ; Pneumonectomy - methods ; Pneumonectomy - standards ; Societies, Medical - standards ; Thoracic Surgery - standards</subject><ispartof>The Annals of thoracic surgery, 2025-01, Vol.119 (1), p.16-33</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2141-467d3fc8e84ac5324722608892900055ad5398744d2a82b7bc36e863d48addde3</cites><orcidid>0000-0001-8889-478X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.athoracsur.2024.09.041$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39424119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Samuel S.</creatorcontrib><creatorcontrib>Cooke, David T.</creatorcontrib><creatorcontrib>Kidane, Biniam</creatorcontrib><creatorcontrib>Tapias, Luis F.</creatorcontrib><creatorcontrib>Lazar, John F.</creatorcontrib><creatorcontrib>Awori Hayanga, Jeremiah W.</creatorcontrib><creatorcontrib>Patel, Jyoti D.</creatorcontrib><creatorcontrib>Neal, Joel W.</creatorcontrib><creatorcontrib>Abazeed, Mohamed E.</creatorcontrib><creatorcontrib>Willers, Henning</creatorcontrib><creatorcontrib>Shrager, Joseph B.</creatorcontrib><title>The Society of Thoracic Surgeons Expert Consensus on the Multidisciplinary Management and Resectability of Locally Advanced Non-small Cell Lung Cancer</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>The contemporary management and resectability of locally advanced lung cancer are undergoing significant changes as new data emerge regarding immunotherapy and targeted treatments. The objective of this document is to review the literature and present consensus among a group of multidisciplinary experts to guide the determination of resectability and management of locally advanced non-small cell lung cancer (NSCLC) in the context of contemporary evidence.
The Society of Thoracic Surgeon Workforce on Thoracic Surgery assembled a multidisciplinary expert panel composed of thoracic surgeons and medical and radiation oncologists with established expertise in the management of lung cancer. A focused literature review was performed, and expert consensus statements were developed using a modified Delphi process to address 3 major themes: (1) assessing resectability and multidisciplinary management of locally advanced lung cancer, (2) neoadjuvant (including perioperative) therapy, and (3) adjuvant therapy.
A consensus was reached on 19 recommendations. These consensus statements reflect updated insights on resectability and multidisciplinary management of locally advanced lung cancer based on the latest literature and current clinical experience, mainly focusing on the appropriateness of surgical therapy and emerging data regarding neoadjuvant and adjuvant therapies.
Despite the complex decision-making process in managing locally advanced lung cancer, this expert panel agreed on several key recommendations. This document provides guidance for thoracic surgeons and other medical professionals in the optimal management of locally advanced lung cancer based on the most updated evidence and literature.</description><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - therapy</subject><subject>Combined Modality Therapy - methods</subject><subject>Combined Modality Therapy - standards</subject><subject>Consensus</subject><subject>Humans</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - therapy</subject><subject>Neoadjuvant Therapy - methods</subject><subject>Neoadjuvant Therapy - standards</subject><subject>Neoplasm Staging</subject><subject>Pneumonectomy - methods</subject><subject>Pneumonectomy - standards</subject><subject>Societies, Medical - standards</subject><subject>Thoracic Surgery - standards</subject><issn>0003-4975</issn><issn>1552-6259</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctuEzEUtRCIhpZfQF6ymcGvmbGXZVRapBQkmq4tx75JHc3YwZ6pyI_0e-uQAks2ft1zzvW5ByFMSU0JbT_tajM9xGRsnlPNCBM1UTUR9BVa0KZhVcsa9RotCCG8EqprztC7nHflykr5LTrjSjBBqVqgp9UD4LtoPUwHHDd49VvWW3w3py3EkPHVrz2kCfflDCHPGceAp0K6nYfJO5-t3w8-mHTAtyaYLYwQJmyCwz8gg53M2g_-pL2M1gzDAV-6RxMsOPwthiqP5Q33UJblHLa4P5bSBXqzMUOG9y_7Obr_crXqb6rl9-uv_eWysowKWom2c3xjJUhhbMOZ6BhriZSKqWK2aYxruJKdEI4Zydbd2vIWZMudkMY5B_wcfTzp7lP8OUOe9Fgclc-YAHHOmlMqOWmo6gpUnqA2xZwTbPQ--bH41pToYyp6p_-loo-paKJ0SaVQP7x0mdcjuL_EPzEUwOcTAIrXRw9Jl7HCcUY-lRlqF_3_uzwDLI-lAA</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Kim, Samuel S.</creator><creator>Cooke, David T.</creator><creator>Kidane, Biniam</creator><creator>Tapias, Luis F.</creator><creator>Lazar, John F.</creator><creator>Awori Hayanga, Jeremiah W.</creator><creator>Patel, Jyoti D.</creator><creator>Neal, Joel W.</creator><creator>Abazeed, Mohamed E.</creator><creator>Willers, Henning</creator><creator>Shrager, Joseph B.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8889-478X</orcidid></search><sort><creationdate>202501</creationdate><title>The Society of Thoracic Surgeons Expert Consensus on the Multidisciplinary Management and Resectability of Locally Advanced Non-small Cell Lung Cancer</title><author>Kim, Samuel S. ; Cooke, David T. ; Kidane, Biniam ; Tapias, Luis F. ; Lazar, John F. ; Awori Hayanga, Jeremiah W. ; Patel, Jyoti D. ; Neal, Joel W. ; Abazeed, Mohamed E. ; Willers, Henning ; Shrager, Joseph B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2141-467d3fc8e84ac5324722608892900055ad5398744d2a82b7bc36e863d48addde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Non-Small-Cell Lung - therapy</topic><topic>Combined Modality Therapy - methods</topic><topic>Combined Modality Therapy - standards</topic><topic>Consensus</topic><topic>Humans</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - therapy</topic><topic>Neoadjuvant Therapy - methods</topic><topic>Neoadjuvant Therapy - standards</topic><topic>Neoplasm Staging</topic><topic>Pneumonectomy - methods</topic><topic>Pneumonectomy - standards</topic><topic>Societies, Medical - standards</topic><topic>Thoracic Surgery - standards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Samuel S.</creatorcontrib><creatorcontrib>Cooke, David T.</creatorcontrib><creatorcontrib>Kidane, Biniam</creatorcontrib><creatorcontrib>Tapias, Luis F.</creatorcontrib><creatorcontrib>Lazar, John F.</creatorcontrib><creatorcontrib>Awori Hayanga, Jeremiah W.</creatorcontrib><creatorcontrib>Patel, Jyoti D.</creatorcontrib><creatorcontrib>Neal, Joel W.</creatorcontrib><creatorcontrib>Abazeed, Mohamed E.</creatorcontrib><creatorcontrib>Willers, Henning</creatorcontrib><creatorcontrib>Shrager, Joseph B.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Samuel S.</au><au>Cooke, David T.</au><au>Kidane, Biniam</au><au>Tapias, Luis F.</au><au>Lazar, John F.</au><au>Awori Hayanga, Jeremiah W.</au><au>Patel, Jyoti D.</au><au>Neal, Joel W.</au><au>Abazeed, Mohamed E.</au><au>Willers, Henning</au><au>Shrager, Joseph B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Society of Thoracic Surgeons Expert Consensus on the Multidisciplinary Management and Resectability of Locally Advanced Non-small Cell Lung Cancer</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>2025-01</date><risdate>2025</risdate><volume>119</volume><issue>1</issue><spage>16</spage><epage>33</epage><pages>16-33</pages><issn>0003-4975</issn><issn>1552-6259</issn><eissn>1552-6259</eissn><abstract>The contemporary management and resectability of locally advanced lung cancer are undergoing significant changes as new data emerge regarding immunotherapy and targeted treatments. The objective of this document is to review the literature and present consensus among a group of multidisciplinary experts to guide the determination of resectability and management of locally advanced non-small cell lung cancer (NSCLC) in the context of contemporary evidence.
The Society of Thoracic Surgeon Workforce on Thoracic Surgery assembled a multidisciplinary expert panel composed of thoracic surgeons and medical and radiation oncologists with established expertise in the management of lung cancer. A focused literature review was performed, and expert consensus statements were developed using a modified Delphi process to address 3 major themes: (1) assessing resectability and multidisciplinary management of locally advanced lung cancer, (2) neoadjuvant (including perioperative) therapy, and (3) adjuvant therapy.
A consensus was reached on 19 recommendations. These consensus statements reflect updated insights on resectability and multidisciplinary management of locally advanced lung cancer based on the latest literature and current clinical experience, mainly focusing on the appropriateness of surgical therapy and emerging data regarding neoadjuvant and adjuvant therapies.
Despite the complex decision-making process in managing locally advanced lung cancer, this expert panel agreed on several key recommendations. This document provides guidance for thoracic surgeons and other medical professionals in the optimal management of locally advanced lung cancer based on the most updated evidence and literature.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>39424119</pmid><doi>10.1016/j.athoracsur.2024.09.041</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0001-8889-478X</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0003-4975 |
| ispartof | The Annals of thoracic surgery, 2025-01, Vol.119 (1), p.16-33 |
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| subjects | Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - therapy Combined Modality Therapy - methods Combined Modality Therapy - standards Consensus Humans Lung Neoplasms - pathology Lung Neoplasms - therapy Neoadjuvant Therapy - methods Neoadjuvant Therapy - standards Neoplasm Staging Pneumonectomy - methods Pneumonectomy - standards Societies, Medical - standards Thoracic Surgery - standards |
| title | The Society of Thoracic Surgeons Expert Consensus on the Multidisciplinary Management and Resectability of Locally Advanced Non-small Cell Lung Cancer |
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