Understanding the probiotic potential of Lactobacillus plantarum: Antioxidant capacity, non-specific immunity and intestinal microbiota improvement effects on Manila clam Ruditapes philippinarum

Lactic acid bacteria (LAB) have beneficial effects on aquatic animals, improving their immune system and intestinal microbiota. Nevertheless, the probiotic effects of LAB on the Manila clam Ruditapes philippinarum remain poorly understood. Herein, the effects of administering Lactobacillus plantarum...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Fish & shellfish immunology 2024-11, Vol.154, p.109971, Article 109971
Hauptverfasser: Liu, Longzhen, Zhuang, Haonan, Tian, Xiangli, Zhou, Yujia, Wang, Fangyi, Liu, Zirong, Li, Jiamin, Jiao, Minghui, Xue, Suyan, Li, Jiaqi, Jiang, Weiwei, Mao, Yuze
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page 109971
container_title Fish & shellfish immunology
container_volume 154
creator Liu, Longzhen
Zhuang, Haonan
Tian, Xiangli
Zhou, Yujia
Wang, Fangyi
Liu, Zirong
Li, Jiamin
Jiao, Minghui
Xue, Suyan
Li, Jiaqi
Jiang, Weiwei
Mao, Yuze
description Lactic acid bacteria (LAB) have beneficial effects on aquatic animals, improving their immune system and intestinal microbiota. Nevertheless, the probiotic effects of LAB on the Manila clam Ruditapes philippinarum remain poorly understood. Herein, the effects of administering Lactobacillus plantarum at final doses of 1 × 105 CFU/L (T5 group), 1 × 107 CFU/L (T7 group), and 1 × 109 CFU/L (T9 group) in the rearing water for eight weeks were evaluated for the antioxidant capacity, non-specific immunity, resistance to Vibrio parahaemolyticus infection, and intestinal microbiota of R. philippinarum. The rearing water without the addition of L. plantarum served as a control. The results showed that the T7 and T9 groups demonstrated a significant elevation in the disease resistance of clams against V. parahaemolyticus, in the activities of alkaline phosphatase and lysozyme in the hepatopancreas, and in the expression of antioxidant- and immune-related genes, including SOD, GPx, and GST. Meanwhile, the T7 group showed a significant enhancement in superoxide dismutase and catalase activities and CAT expression, while the T9 group experienced a remarkable elevation in reduced glutathione content. Only catalase activity was markedly elevated in the T5 group. The expression of SOD, CAT, GPx, and GST was significantly elevated in three treatment groups following the V. parahaemolyticus challenge. The T7 group exhibited a significant increase in intestinal microbiota richness. Significant increases were noted in Firmicutes abundance across all three treatment groups and in Actinobacteriota in the T5 and T7 groups. Additionally, the opportunistic pathogen Escherichia-Shigella abundance significantly decreased in three treatment groups. Furthermore, administration of 1 × 107 CFU/L L. plantarum enhanced the stability of the intestinal microecosystem, whereas a dose of 1 × 109 CFU/L might have a negative effect. The application of three doses of L. plantarum significantly enhanced intestinal microbiota functions related to the immune response and oxidative stress regulation, while a higher dose (1 × 109 CFU/L) might inhibit several functions. In conclusion, the application of L. plantarum in the rearing water exerted beneficial effects on the antioxidant capacity, non-specific immunity, resistance to V. parahaemolyticus, and the intestinal microbiota stability and functions of R. philippinarum. The beneficial effects of L. plantarum on R. philippinarum were dose-dependent, a
doi_str_mv 10.1016/j.fsi.2024.109971
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3118304838</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1050464824006168</els_id><sourcerecordid>3118304838</sourcerecordid><originalsourceid>FETCH-LOGICAL-c235t-49e88cf2f7fc5084a170082432b8269cbdf8c74a3a8e3284517c89b714558f4d3</originalsourceid><addsrcrecordid>eNp9UU1v1TAQjBCIlsIP4IJ85EAeduwkDpyqio9KD1Wq6NlynDXdp8QOsVO1f49fxj6lcOzJ69XszM5OUbwVfCe4aD4edj7hruKVon_XteJZcUpFXXadap8f65qXqlH6pHiV0oFz3siGvyxOZKcq2XF1Wvy5CQMsKdswYPjF8i2weYk9xoyOzTFDyGhHFj3bW5djbx2O45rYPNqQ7bJOn9g5QeI9DtRgzs6EyA8fWIihTDM49ESE07QGajOSYRgypIyBaCd0m5glCOnewUSCDLwHlxOLgf2wAUfL3Ggndr0OmO0MpH6LI84zcdAGr4sX3o4J3jy-Z8XN1y8_L76X-6tvlxfn-9JVss6l6kBr5yvfeldzraxoOdeVklWvq6Zz_eC1a5WVVoOstKpF63TXt0LVtfZqkGfF-42XFv29kgUzYXIw0iUgrslIIbTkSktNULFByV5KC3gzLzjZ5cEIbo7RmYOh6MwxOrNFRzPvHunXfoLh_8S_rAjweQMAmbxDWExyCMHBgAudywwRn6D_C-AYr1Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3118304838</pqid></control><display><type>article</type><title>Understanding the probiotic potential of Lactobacillus plantarum: Antioxidant capacity, non-specific immunity and intestinal microbiota improvement effects on Manila clam Ruditapes philippinarum</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Liu, Longzhen ; Zhuang, Haonan ; Tian, Xiangli ; Zhou, Yujia ; Wang, Fangyi ; Liu, Zirong ; Li, Jiamin ; Jiao, Minghui ; Xue, Suyan ; Li, Jiaqi ; Jiang, Weiwei ; Mao, Yuze</creator><creatorcontrib>Liu, Longzhen ; Zhuang, Haonan ; Tian, Xiangli ; Zhou, Yujia ; Wang, Fangyi ; Liu, Zirong ; Li, Jiamin ; Jiao, Minghui ; Xue, Suyan ; Li, Jiaqi ; Jiang, Weiwei ; Mao, Yuze</creatorcontrib><description>Lactic acid bacteria (LAB) have beneficial effects on aquatic animals, improving their immune system and intestinal microbiota. Nevertheless, the probiotic effects of LAB on the Manila clam Ruditapes philippinarum remain poorly understood. Herein, the effects of administering Lactobacillus plantarum at final doses of 1 × 105 CFU/L (T5 group), 1 × 107 CFU/L (T7 group), and 1 × 109 CFU/L (T9 group) in the rearing water for eight weeks were evaluated for the antioxidant capacity, non-specific immunity, resistance to Vibrio parahaemolyticus infection, and intestinal microbiota of R. philippinarum. The rearing water without the addition of L. plantarum served as a control. The results showed that the T7 and T9 groups demonstrated a significant elevation in the disease resistance of clams against V. parahaemolyticus, in the activities of alkaline phosphatase and lysozyme in the hepatopancreas, and in the expression of antioxidant- and immune-related genes, including SOD, GPx, and GST. Meanwhile, the T7 group showed a significant enhancement in superoxide dismutase and catalase activities and CAT expression, while the T9 group experienced a remarkable elevation in reduced glutathione content. Only catalase activity was markedly elevated in the T5 group. The expression of SOD, CAT, GPx, and GST was significantly elevated in three treatment groups following the V. parahaemolyticus challenge. The T7 group exhibited a significant increase in intestinal microbiota richness. Significant increases were noted in Firmicutes abundance across all three treatment groups and in Actinobacteriota in the T5 and T7 groups. Additionally, the opportunistic pathogen Escherichia-Shigella abundance significantly decreased in three treatment groups. Furthermore, administration of 1 × 107 CFU/L L. plantarum enhanced the stability of the intestinal microecosystem, whereas a dose of 1 × 109 CFU/L might have a negative effect. The application of three doses of L. plantarum significantly enhanced intestinal microbiota functions related to the immune response and oxidative stress regulation, while a higher dose (1 × 109 CFU/L) might inhibit several functions. In conclusion, the application of L. plantarum in the rearing water exerted beneficial effects on the antioxidant capacity, non-specific immunity, resistance to V. parahaemolyticus, and the intestinal microbiota stability and functions of R. philippinarum. The beneficial effects of L. plantarum on R. philippinarum were dose-dependent, and the final dose of 1 × 107 CFU/L exhibited the optimal effects. •Lactobacillus plantarum enhanced non-specific immunity of Ruditapes philippinarum.•L. plantarum improved the intestinal microbiota of R. philippinarum.•The probiotic effects of L. plantarum on R. philippinarum were dose-dependent.•The 1 × 107 CFU/L L. plantarum showed the best probiotic effects on R. philippinarum.</description><identifier>ISSN: 1050-4648</identifier><identifier>ISSN: 1095-9947</identifier><identifier>EISSN: 1095-9947</identifier><identifier>DOI: 10.1016/j.fsi.2024.109971</identifier><identifier>PMID: 39423904</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animal Feed - analysis ; Animals ; Antioxidant capacity ; Antioxidants - metabolism ; Bivalvia - immunology ; Bivalvia - microbiology ; Diet - veterinary ; Gastrointestinal Microbiome - drug effects ; Immunity, Innate ; Intestinal microbiota ; Lactobacillus plantarum - chemistry ; Non-specific immunity ; Probiotics ; Probiotics - administration &amp; dosage ; Probiotics - pharmacology ; Random Allocation ; Ruditapes philippinarum ; Vibrio parahaemolyticus - physiology</subject><ispartof>Fish &amp; shellfish immunology, 2024-11, Vol.154, p.109971, Article 109971</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c235t-49e88cf2f7fc5084a170082432b8269cbdf8c74a3a8e3284517c89b714558f4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fsi.2024.109971$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39423904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Longzhen</creatorcontrib><creatorcontrib>Zhuang, Haonan</creatorcontrib><creatorcontrib>Tian, Xiangli</creatorcontrib><creatorcontrib>Zhou, Yujia</creatorcontrib><creatorcontrib>Wang, Fangyi</creatorcontrib><creatorcontrib>Liu, Zirong</creatorcontrib><creatorcontrib>Li, Jiamin</creatorcontrib><creatorcontrib>Jiao, Minghui</creatorcontrib><creatorcontrib>Xue, Suyan</creatorcontrib><creatorcontrib>Li, Jiaqi</creatorcontrib><creatorcontrib>Jiang, Weiwei</creatorcontrib><creatorcontrib>Mao, Yuze</creatorcontrib><title>Understanding the probiotic potential of Lactobacillus plantarum: Antioxidant capacity, non-specific immunity and intestinal microbiota improvement effects on Manila clam Ruditapes philippinarum</title><title>Fish &amp; shellfish immunology</title><addtitle>Fish Shellfish Immunol</addtitle><description>Lactic acid bacteria (LAB) have beneficial effects on aquatic animals, improving their immune system and intestinal microbiota. Nevertheless, the probiotic effects of LAB on the Manila clam Ruditapes philippinarum remain poorly understood. Herein, the effects of administering Lactobacillus plantarum at final doses of 1 × 105 CFU/L (T5 group), 1 × 107 CFU/L (T7 group), and 1 × 109 CFU/L (T9 group) in the rearing water for eight weeks were evaluated for the antioxidant capacity, non-specific immunity, resistance to Vibrio parahaemolyticus infection, and intestinal microbiota of R. philippinarum. The rearing water without the addition of L. plantarum served as a control. The results showed that the T7 and T9 groups demonstrated a significant elevation in the disease resistance of clams against V. parahaemolyticus, in the activities of alkaline phosphatase and lysozyme in the hepatopancreas, and in the expression of antioxidant- and immune-related genes, including SOD, GPx, and GST. Meanwhile, the T7 group showed a significant enhancement in superoxide dismutase and catalase activities and CAT expression, while the T9 group experienced a remarkable elevation in reduced glutathione content. Only catalase activity was markedly elevated in the T5 group. The expression of SOD, CAT, GPx, and GST was significantly elevated in three treatment groups following the V. parahaemolyticus challenge. The T7 group exhibited a significant increase in intestinal microbiota richness. Significant increases were noted in Firmicutes abundance across all three treatment groups and in Actinobacteriota in the T5 and T7 groups. Additionally, the opportunistic pathogen Escherichia-Shigella abundance significantly decreased in three treatment groups. Furthermore, administration of 1 × 107 CFU/L L. plantarum enhanced the stability of the intestinal microecosystem, whereas a dose of 1 × 109 CFU/L might have a negative effect. The application of three doses of L. plantarum significantly enhanced intestinal microbiota functions related to the immune response and oxidative stress regulation, while a higher dose (1 × 109 CFU/L) might inhibit several functions. In conclusion, the application of L. plantarum in the rearing water exerted beneficial effects on the antioxidant capacity, non-specific immunity, resistance to V. parahaemolyticus, and the intestinal microbiota stability and functions of R. philippinarum. The beneficial effects of L. plantarum on R. philippinarum were dose-dependent, and the final dose of 1 × 107 CFU/L exhibited the optimal effects. •Lactobacillus plantarum enhanced non-specific immunity of Ruditapes philippinarum.•L. plantarum improved the intestinal microbiota of R. philippinarum.•The probiotic effects of L. plantarum on R. philippinarum were dose-dependent.•The 1 × 107 CFU/L L. plantarum showed the best probiotic effects on R. philippinarum.</description><subject>Animal Feed - analysis</subject><subject>Animals</subject><subject>Antioxidant capacity</subject><subject>Antioxidants - metabolism</subject><subject>Bivalvia - immunology</subject><subject>Bivalvia - microbiology</subject><subject>Diet - veterinary</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Immunity, Innate</subject><subject>Intestinal microbiota</subject><subject>Lactobacillus plantarum - chemistry</subject><subject>Non-specific immunity</subject><subject>Probiotics</subject><subject>Probiotics - administration &amp; dosage</subject><subject>Probiotics - pharmacology</subject><subject>Random Allocation</subject><subject>Ruditapes philippinarum</subject><subject>Vibrio parahaemolyticus - physiology</subject><issn>1050-4648</issn><issn>1095-9947</issn><issn>1095-9947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1TAQjBCIlsIP4IJ85EAeduwkDpyqio9KD1Wq6NlynDXdp8QOsVO1f49fxj6lcOzJ69XszM5OUbwVfCe4aD4edj7hruKVon_XteJZcUpFXXadap8f65qXqlH6pHiV0oFz3siGvyxOZKcq2XF1Wvy5CQMsKdswYPjF8i2weYk9xoyOzTFDyGhHFj3bW5djbx2O45rYPNqQ7bJOn9g5QeI9DtRgzs6EyA8fWIihTDM49ESE07QGajOSYRgypIyBaCd0m5glCOnewUSCDLwHlxOLgf2wAUfL3Ggndr0OmO0MpH6LI84zcdAGr4sX3o4J3jy-Z8XN1y8_L76X-6tvlxfn-9JVss6l6kBr5yvfeldzraxoOdeVklWvq6Zz_eC1a5WVVoOstKpF63TXt0LVtfZqkGfF-42XFv29kgUzYXIw0iUgrslIIbTkSktNULFByV5KC3gzLzjZ5cEIbo7RmYOh6MwxOrNFRzPvHunXfoLh_8S_rAjweQMAmbxDWExyCMHBgAudywwRn6D_C-AYr1Q</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Liu, Longzhen</creator><creator>Zhuang, Haonan</creator><creator>Tian, Xiangli</creator><creator>Zhou, Yujia</creator><creator>Wang, Fangyi</creator><creator>Liu, Zirong</creator><creator>Li, Jiamin</creator><creator>Jiao, Minghui</creator><creator>Xue, Suyan</creator><creator>Li, Jiaqi</creator><creator>Jiang, Weiwei</creator><creator>Mao, Yuze</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202411</creationdate><title>Understanding the probiotic potential of Lactobacillus plantarum: Antioxidant capacity, non-specific immunity and intestinal microbiota improvement effects on Manila clam Ruditapes philippinarum</title><author>Liu, Longzhen ; Zhuang, Haonan ; Tian, Xiangli ; Zhou, Yujia ; Wang, Fangyi ; Liu, Zirong ; Li, Jiamin ; Jiao, Minghui ; Xue, Suyan ; Li, Jiaqi ; Jiang, Weiwei ; Mao, Yuze</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c235t-49e88cf2f7fc5084a170082432b8269cbdf8c74a3a8e3284517c89b714558f4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animal Feed - analysis</topic><topic>Animals</topic><topic>Antioxidant capacity</topic><topic>Antioxidants - metabolism</topic><topic>Bivalvia - immunology</topic><topic>Bivalvia - microbiology</topic><topic>Diet - veterinary</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Immunity, Innate</topic><topic>Intestinal microbiota</topic><topic>Lactobacillus plantarum - chemistry</topic><topic>Non-specific immunity</topic><topic>Probiotics</topic><topic>Probiotics - administration &amp; dosage</topic><topic>Probiotics - pharmacology</topic><topic>Random Allocation</topic><topic>Ruditapes philippinarum</topic><topic>Vibrio parahaemolyticus - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Longzhen</creatorcontrib><creatorcontrib>Zhuang, Haonan</creatorcontrib><creatorcontrib>Tian, Xiangli</creatorcontrib><creatorcontrib>Zhou, Yujia</creatorcontrib><creatorcontrib>Wang, Fangyi</creatorcontrib><creatorcontrib>Liu, Zirong</creatorcontrib><creatorcontrib>Li, Jiamin</creatorcontrib><creatorcontrib>Jiao, Minghui</creatorcontrib><creatorcontrib>Xue, Suyan</creatorcontrib><creatorcontrib>Li, Jiaqi</creatorcontrib><creatorcontrib>Jiang, Weiwei</creatorcontrib><creatorcontrib>Mao, Yuze</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fish &amp; shellfish immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Longzhen</au><au>Zhuang, Haonan</au><au>Tian, Xiangli</au><au>Zhou, Yujia</au><au>Wang, Fangyi</au><au>Liu, Zirong</au><au>Li, Jiamin</au><au>Jiao, Minghui</au><au>Xue, Suyan</au><au>Li, Jiaqi</au><au>Jiang, Weiwei</au><au>Mao, Yuze</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Understanding the probiotic potential of Lactobacillus plantarum: Antioxidant capacity, non-specific immunity and intestinal microbiota improvement effects on Manila clam Ruditapes philippinarum</atitle><jtitle>Fish &amp; shellfish immunology</jtitle><addtitle>Fish Shellfish Immunol</addtitle><date>2024-11</date><risdate>2024</risdate><volume>154</volume><spage>109971</spage><pages>109971-</pages><artnum>109971</artnum><issn>1050-4648</issn><issn>1095-9947</issn><eissn>1095-9947</eissn><abstract>Lactic acid bacteria (LAB) have beneficial effects on aquatic animals, improving their immune system and intestinal microbiota. Nevertheless, the probiotic effects of LAB on the Manila clam Ruditapes philippinarum remain poorly understood. Herein, the effects of administering Lactobacillus plantarum at final doses of 1 × 105 CFU/L (T5 group), 1 × 107 CFU/L (T7 group), and 1 × 109 CFU/L (T9 group) in the rearing water for eight weeks were evaluated for the antioxidant capacity, non-specific immunity, resistance to Vibrio parahaemolyticus infection, and intestinal microbiota of R. philippinarum. The rearing water without the addition of L. plantarum served as a control. The results showed that the T7 and T9 groups demonstrated a significant elevation in the disease resistance of clams against V. parahaemolyticus, in the activities of alkaline phosphatase and lysozyme in the hepatopancreas, and in the expression of antioxidant- and immune-related genes, including SOD, GPx, and GST. Meanwhile, the T7 group showed a significant enhancement in superoxide dismutase and catalase activities and CAT expression, while the T9 group experienced a remarkable elevation in reduced glutathione content. Only catalase activity was markedly elevated in the T5 group. The expression of SOD, CAT, GPx, and GST was significantly elevated in three treatment groups following the V. parahaemolyticus challenge. The T7 group exhibited a significant increase in intestinal microbiota richness. Significant increases were noted in Firmicutes abundance across all three treatment groups and in Actinobacteriota in the T5 and T7 groups. Additionally, the opportunistic pathogen Escherichia-Shigella abundance significantly decreased in three treatment groups. Furthermore, administration of 1 × 107 CFU/L L. plantarum enhanced the stability of the intestinal microecosystem, whereas a dose of 1 × 109 CFU/L might have a negative effect. The application of three doses of L. plantarum significantly enhanced intestinal microbiota functions related to the immune response and oxidative stress regulation, while a higher dose (1 × 109 CFU/L) might inhibit several functions. In conclusion, the application of L. plantarum in the rearing water exerted beneficial effects on the antioxidant capacity, non-specific immunity, resistance to V. parahaemolyticus, and the intestinal microbiota stability and functions of R. philippinarum. The beneficial effects of L. plantarum on R. philippinarum were dose-dependent, and the final dose of 1 × 107 CFU/L exhibited the optimal effects. •Lactobacillus plantarum enhanced non-specific immunity of Ruditapes philippinarum.•L. plantarum improved the intestinal microbiota of R. philippinarum.•The probiotic effects of L. plantarum on R. philippinarum were dose-dependent.•The 1 × 107 CFU/L L. plantarum showed the best probiotic effects on R. philippinarum.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39423904</pmid><doi>10.1016/j.fsi.2024.109971</doi></addata></record>
fulltext fulltext
identifier ISSN: 1050-4648
ispartof Fish & shellfish immunology, 2024-11, Vol.154, p.109971, Article 109971
issn 1050-4648
1095-9947
1095-9947
language eng
recordid cdi_proquest_miscellaneous_3118304838
source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Animal Feed - analysis
Animals
Antioxidant capacity
Antioxidants - metabolism
Bivalvia - immunology
Bivalvia - microbiology
Diet - veterinary
Gastrointestinal Microbiome - drug effects
Immunity, Innate
Intestinal microbiota
Lactobacillus plantarum - chemistry
Non-specific immunity
Probiotics
Probiotics - administration & dosage
Probiotics - pharmacology
Random Allocation
Ruditapes philippinarum
Vibrio parahaemolyticus - physiology
title Understanding the probiotic potential of Lactobacillus plantarum: Antioxidant capacity, non-specific immunity and intestinal microbiota improvement effects on Manila clam Ruditapes philippinarum
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T20%3A24%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Understanding%20the%20probiotic%20potential%20of%20Lactobacillus%20plantarum:%20Antioxidant%20capacity,%20non-specific%20immunity%20and%20intestinal%20microbiota%20improvement%20effects%20on%20Manila%20clam%20Ruditapes%20philippinarum&rft.jtitle=Fish%20&%20shellfish%20immunology&rft.au=Liu,%20Longzhen&rft.date=2024-11&rft.volume=154&rft.spage=109971&rft.pages=109971-&rft.artnum=109971&rft.issn=1050-4648&rft.eissn=1095-9947&rft_id=info:doi/10.1016/j.fsi.2024.109971&rft_dat=%3Cproquest_cross%3E3118304838%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3118304838&rft_id=info:pmid/39423904&rft_els_id=S1050464824006168&rfr_iscdi=true