$Cardiometabolic effects of sacubitril/valsartan in a rat model of heart failure with preserved ejection fraction$

Cardiometabolic effects of sacubitril/valsartan in a rat model of heart failure with preserved ejection fraction

[Display omitted] The promising results obtained in the PARADIGM-HF trial prompted the approval of sacubitril/valsartan (SAC/VAL) as a first-in-class treatment for heart failure with reduced ejection fraction (HFrEF) patients. The effect of SAC/VAL treatment was also studied in patients with heart f...

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Veröffentlicht in:	Biochemical pharmacology 2024-12, Vol.230 (Pt 1), p.116571, Article 116571
Hauptverfasser:	Moraña-Fernández, Sandra, Vázquez-Abuín, Xocas, Aragón-Herrera, Alana, Anido-Varela, Laura, García-Seara, Javier, Otero-García, Óscar, Rodríguez-Penas, Diego, Campos-Toimil, Manuel, Otero-Santiago, Manuel, Rodrigues, Alexandre, Gonçalves, Alexandre, Pereira Morais, Juliana, Alves, Inês N., Sousa-Mendes, Cláudia, Falcão-Pires, Inês, González-Juanatey, José Ramón, Feijóo-Bandín, Sandra, Lago, Francisca
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminobutyrates - pharmacology Aminobutyrates - therapeutic use Angiotensin Receptor Antagonists - pharmacology Angiotensin Receptor Antagonists - therapeutic use Animals Biphenyl Compounds - pharmacology Diastolic dysfunction Disease Models, Animal Drug Combinations Heart Failure - drug therapy Heart Failure - metabolism Heart Failure - physiopathology Heart failure with preserved ejection fraction Male Metabolome Rats Rats, Inbred SHR Rats, Zucker Sacubitril/valsartan Stroke Volume - drug effects Stroke Volume - physiology Tetrazoles - pharmacology Tetrazoles - therapeutic use Valsartan ZSF1
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