A conserved fertilization complex bridges sperm and egg in vertebrates

Fertilization, the basis for sexual reproduction, culminates in the binding and fusion of sperm and egg. Although several proteins are known to be crucial for this process in vertebrates, the molecular mechanisms remain poorly understood. Using an AlphaFold-Multimer screen, we identified the protein...

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Veröffentlicht in:	Cell 2024-12, Vol.187 (25), p.7066-7078.e22
Hauptverfasser:	Deneke, Victoria E., Blaha, Andreas, Lu, Yonggang, Suwita, Johannes P., Draper, Jonne M., Phan, Clara S., Panser, Karin, Schleiffer, Alexander, Jacob, Laurine, Humer, Theresa, Stejskal, Karel, Krssakova, Gabriela, Roitinger, Elisabeth, Handler, Dominik, Kamoshita, Maki, Vance, Tyler D.R., Wang, Xinyin, Surm, Joachim M., Moran, Yehu, Lee, Jeffrey E., Ikawa, Masahito, Pauli, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	AlphaFold Animals Female Fertilization gamete adhesion Humans Immunoglobulins - metabolism Male male fertility Membrane Proteins - metabolism Mice Ovum - metabolism protein-protein interaction sperm proteome sperm-egg interaction Sperm-Ovum Interactions Spermatozoa - metabolism vertebrate fertilization zebrafish Zebrafish - metabolism Zebrafish Proteins - metabolism
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