Multifunctional sericin-based biomineralized nanoplatforms with immunomodulatory and angio/osteo-genic activity for accelerated bone regeneration in periodontitis

Periodontitis is a chronic inflammation caused by dental plaque. It is characterized by the accumulation of excessive reactive oxygen species (ROS) and inflammatory mediators in the periodontal area. This affects the function of host cells, activates osteoclasts, and destroys periodontal tissue. Tre...

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Veröffentlicht in:	Biomaterials 2025-03, Vol.314, p.122885, Article 122885
Hauptverfasser:	Ming, Piaoye, Li, Bojiang, Li, Qiumei, Yuan, Lingling, Jiang, Xueyu, Liu, Yunfei, Cai, Rui, Zhou, Peirong, Lan, Xiaorong, Tao, Gang, Xiao, Jingang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomimetic mineralization Biomineralization - drug effects Bone Regeneration - drug effects Immunologic Factors - chemistry Immunologic Factors - pharmacology Immunologic Factors - therapeutic use Male Mice Multifunctional nanoplatforms Nanoparticles - chemistry Neovascularization, Physiologic - drug effects Osteogenesis - drug effects Periodontal tissue regeneration Periodontitis - drug therapy Periodontitis - pathology RAW 264.7 Cells Reactive Oxygen Species - metabolism ROS-scavenging Sericin nanoparticles Sericins - chemistry Sericins - pharmacology
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