Modified mesoporous silica nanocarriers containing superparamagnetic iron oxide nanoparticle, 5-fluorouracil or oxaliplatin, and metformin as a radiosensitizer, significantly impact colorectal cancer radiation therapy

[Display omitted] This study investigates the anticancer effects of SPION-based silica nanoparticles carrying 5-fluorouracil (5-FU) or oxaliplatin (OX), and metformin (MET) on colorectal cancer cells. Nanocarriers were equipped with pH-responsive gold gatekeepers for controlled release, PEGylation f...

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Veröffentlicht in:	International journal of pharmaceutics 2024-12, Vol.666, p.124838, Article 124838
Hauptverfasser:	Khalili-Hezarjaribi, Hojjat, Bahrami, Ahmad Reza, Sh. Saljooghi, Amir, Matin, Maryam M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Cell Survival - drug effects Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Drug Carriers - chemistry Drug Liberation Fluorouracil - administration & dosage Fluorouracil - chemistry Fluorouracil - pharmacology Folic acid Folic Acid - administration & dosage Folic Acid - chemistry HT29 Cells Humans Magnetic Iron Oxide Nanoparticles - chemistry Mesoporous silica nanoparticle Metformin Metformin - administration & dosage Metformin - chemistry Metformin - pharmacokinetics Metformin - pharmacology Mice Mice, Inbred C57BL Oxaliplatin - administration & dosage Oxaliplatin - pharmacology Radiation-Sensitizing Agents - administration & dosage Radiation-Sensitizing Agents - chemistry Radiation-Sensitizing Agents - pharmacokinetics Radiation-Sensitizing Agents - pharmacology Radiosensitizer Silicon Dioxide - administration & dosage Silicon Dioxide - chemistry Superparamagnetic iron oxide nanoparticle Targeted therapy
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