Thione-Directed C–H Amidation of Chromone Analogues with Dioxazolones under Rh(III) Catalysis

Sulfur-containing organic molecules are recognized as promising candidates for catalytic C–H functionalization and medicinal chemistry owing to the exceptional ability of the sulfur atom to bind to transition metals and target enzymes. In this study, we report the Rh(III)-catalyzed thione-directed...

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Veröffentlicht in:	Organic letters 2024-10, Vol.26 (42), p.9157-9161
Hauptverfasser:	Min, Jeonghyun, Park, Keunju, Moon, Kyeongwon, Kim, Hyung Sik, Singh, Pargat, Kim, In Su
Format:	Artikel
Sprache:	eng
Schlagworte:	carbon-hydrogen bond activation catalytic activity flavones isoflavones sulfur xanthones
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creator	Min, Jeonghyun Park, Keunju Moon, Kyeongwon Kim, Hyung Sik Singh, Pargat Kim, In Su
description	Sulfur-containing organic molecules are recognized as promising candidates for catalytic C–H functionalization and medicinal chemistry owing to the exceptional ability of the sulfur atom to bind to transition metals and target enzymes. In this study, we report the Rh(III)-catalyzed thione-directed C–H amidation of various thiochromone analogues derived from flavones, isoflavones, and xanthones. Post-transformations of C5-amidated thiochromone products were investigated, and a series of mechanistic studies were performed.
doi_str_mv	10.1021/acs.orglett.4c03646
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subjects	carbon-hydrogen bond activation catalytic activity flavones isoflavones sulfur xanthones
title	Thione-Directed C–H Amidation of Chromone Analogues with Dioxazolones under Rh(III) Catalysis
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