Mammary analogue secretory carcinoma involving submandibular gland: Diagnostic pitfall with review of literature
Mammary analogue secretory carcinoma (MASC) is a recently defined entity among salivary gland tumors. MASC bores a striking resemblance to secretory carcinoma of breast along with the characteristics of ETV6-NTRK3 translocation. Hence, the entity was designated as MASC and was formally included in t...
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Veröffentlicht in: | Journal of cancer research and therapeutics 2024-07, Vol.20 (5), p.1658-1661 |
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description | Mammary analogue secretory carcinoma (MASC) is a recently defined entity among salivary gland tumors. MASC bores a striking resemblance to secretory carcinoma of breast along with the characteristics of ETV6-NTRK3 translocation. Hence, the entity was designated as MASC and was formally included in the 4th edition of World Health Organization classification of head and neck tumors in 2017. To the best of our knowledge, around 12 cases of MASC have been described in the Indian literature. MASC commonly involves parotid gland (70%). Involvement of submandibular gland is still rarer (7%). Prognosis of MASC is comparable to other low grade salivary gland malignancies; however, aggressive behavior has also been reported in few cases. This case is one of the very few reported cases describing MASC with detailed clinical, cytology, and microscopy findings along with special stains and immunohistochemistry. |
doi_str_mv | 10.4103/jcrt.jcrt_2148_22 |
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MASC bores a striking resemblance to secretory carcinoma of breast along with the characteristics of ETV6-NTRK3 translocation. Hence, the entity was designated as MASC and was formally included in the 4th edition of World Health Organization classification of head and neck tumors in 2017. To the best of our knowledge, around 12 cases of MASC have been described in the Indian literature. MASC commonly involves parotid gland (70%). Involvement of submandibular gland is still rarer (7%). Prognosis of MASC is comparable to other low grade salivary gland malignancies; however, aggressive behavior has also been reported in few cases. 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MASC bores a striking resemblance to secretory carcinoma of breast along with the characteristics of ETV6-NTRK3 translocation. Hence, the entity was designated as MASC and was formally included in the 4th edition of World Health Organization classification of head and neck tumors in 2017. To the best of our knowledge, around 12 cases of MASC have been described in the Indian literature. MASC commonly involves parotid gland (70%). Involvement of submandibular gland is still rarer (7%). Prognosis of MASC is comparable to other low grade salivary gland malignancies; however, aggressive behavior has also been reported in few cases. This case is one of the very few reported cases describing MASC with detailed clinical, cytology, and microscopy findings along with special stains and immunohistochemistry.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. 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subjects | Adult Care and treatment Diagnosis Diagnosis, Differential Female Genetic aspects Head & neck cancer Health aspects Humans Immunohistochemistry Male Mammary Analogue Secretory Carcinoma - diagnosis Mammary Analogue Secretory Carcinoma - genetics Mammary Analogue Secretory Carcinoma - pathology Oral cancer Parotid glands Physiological aspects Prognosis Salivary Gland Neoplasms - diagnosis Salivary Gland Neoplasms - pathology Salivary gland tumors Submandibular Gland - pathology Submandibular Gland Neoplasms - diagnosis Submandibular Gland Neoplasms - pathology Translocation (Genetics) |
title | Mammary analogue secretory carcinoma involving submandibular gland: Diagnostic pitfall with review of literature |
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