Mammary analogue secretory carcinoma involving submandibular gland: Diagnostic pitfall with review of literature

Mammary analogue secretory carcinoma (MASC) is a recently defined entity among salivary gland tumors. MASC bores a striking resemblance to secretory carcinoma of breast along with the characteristics of ETV6-NTRK3 translocation. Hence, the entity was designated as MASC and was formally included in t...

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Veröffentlicht in:Journal of cancer research and therapeutics 2024-07, Vol.20 (5), p.1658-1661
Hauptverfasser: Dhankar, Nimisha, Verma, Nidhi, Agarwal, Abhinav, Mehar, Ravi, Pasricha, Sunil
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container_end_page 1661
container_issue 5
container_start_page 1658
container_title Journal of cancer research and therapeutics
container_volume 20
creator Dhankar, Nimisha
Verma, Nidhi
Agarwal, Abhinav
Mehar, Ravi
Pasricha, Sunil
description Mammary analogue secretory carcinoma (MASC) is a recently defined entity among salivary gland tumors. MASC bores a striking resemblance to secretory carcinoma of breast along with the characteristics of ETV6-NTRK3 translocation. Hence, the entity was designated as MASC and was formally included in the 4th edition of World Health Organization classification of head and neck tumors in 2017. To the best of our knowledge, around 12 cases of MASC have been described in the Indian literature. MASC commonly involves parotid gland (70%). Involvement of submandibular gland is still rarer (7%). Prognosis of MASC is comparable to other low grade salivary gland malignancies; however, aggressive behavior has also been reported in few cases. This case is one of the very few reported cases describing MASC with detailed clinical, cytology, and microscopy findings along with special stains and immunohistochemistry.
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source MEDLINE; Medknow Open Access Medical Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Adult
Care and treatment
Diagnosis
Diagnosis, Differential
Female
Genetic aspects
Head & neck cancer
Health aspects
Humans
Immunohistochemistry
Male
Mammary Analogue Secretory Carcinoma - diagnosis
Mammary Analogue Secretory Carcinoma - genetics
Mammary Analogue Secretory Carcinoma - pathology
Oral cancer
Parotid glands
Physiological aspects
Prognosis
Salivary Gland Neoplasms - diagnosis
Salivary Gland Neoplasms - pathology
Salivary gland tumors
Submandibular Gland - pathology
Submandibular Gland Neoplasms - diagnosis
Submandibular Gland Neoplasms - pathology
Translocation (Genetics)
title Mammary analogue secretory carcinoma involving submandibular gland: Diagnostic pitfall with review of literature
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