Polymer nanodiscs support the functional extraction of an artificial transmembrane cytochrome

Polymer nanodiscs are an attractive alternative to surfactants for studying integral membrane proteins within their native lipid environment. Here, we investigate the use of such polymers to isolate a computationally-designed de novo membrane cytochrome named CytbX. We show that the block copolymers...

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Veröffentlicht in:	Biochimica et biophysica acta. Biomembranes 2025-01, Vol.1867 (1), p.184392, Article 184392
Hauptverfasser:	Hardy, Benjamin J., Ford, Holly C., Rudin, May, Anderson, J.L. Ross, Curnow, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytochrome Cytochromes - chemistry Cytochromes - metabolism Electron Transport Lipid Bilayers - chemistry Membrane protein purification Membrane Proteins - chemistry Membrane Proteins - metabolism Micelles Nanostructures - chemistry Polymer nanodisc Polymers - chemistry Protein design
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