Involvement of Proton-Coupled Organic Cation Antiporter in Human Blood–Brain Barrier Transport of Mesoridazine and Metoclopramide

Mesoridazine and metoclopramide are cationic drugs that are distributed in the human brain despite being substrates of multidrug resistance protein 1 (MDR1), an efflux transporter expressed at the blood–brain barrier (BBB). We investigated their transport mechanisms at the BBB using hCMEC/D3, a huma...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2024/10/16, Vol.47(10), pp.1662-1667
Hauptverfasser:	Debori, Yasuyuki, Igari, Tomoko, Nakakariya, Masanori, Hirabayashi, Hideki, Aoyama, Kazunobu, Amano, Nobuyuki, Kurosawa, Toshiki, Kubo, Yoshiyuki, Deguchi, Yoshiharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Antiporters - metabolism Biological Transport Blood-brain barrier Blood-Brain Barrier - metabolism cationic drug Cell Line Drug resistance Endothelial cells Endothelial Cells - metabolism hCMEC/D3 cell Humans Hydrogen membrane transport Metoclopramide Metoclopramide - metabolism Metoclopramide - pharmacology Microvasculature Monoamine transporter Multidrug resistance Organic Cation Transport Proteins - metabolism P-Glycoprotein Protein transport transporter
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