Affibody-Drug Conjugates Targeting the Human Epidermal Growth Factor Receptor‑3 Demonstrate Therapeutic Efficacy in Mice Bearing Low Expressing Xenografts

The outcome of clinical trials evaluating drugs targeting the human epidermal growth factor receptor 3 (HER3) has been poor, with primary concerns related to lack of efficacy. HER3 is considered a difficult target since its overexpression on tumors is relatively low and there is normal expression in...

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Veröffentlicht in:	ACS pharmacology & translational science 2024-10, Vol.7 (10), p.3228-3240
Hauptverfasser:	Zhang, Jie, Rinne, Sara S., Yin, Wen, Leitao, Charles Dahlsson, Björklund, Elvira, Abouzayed, Ayman, Ståhl, Stefan, Löfblom, John, Orlova, Anna, Gräslund, Torbjörn, Vorobyeva, Anzhelika
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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