Cannabiorcol as a novel inhibitor of the p38/MSK-1/NF-κB signaling pathway, reducing matrix metalloproteinases in osteoarthritis

The bioactivity and potential medicinal applications of cannabiorcol, a lesser-known derivative of Cannabis sativa, require further investigation. Osteoarthritis (OA) is a chronic joint condition marked by gradual degradation of the cartilage and commonly associated with elevated levels of matrix me...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2024-12, Vol.135, p.156141, Article 156141
Hauptverfasser:	Jeon, Youngsic, Kim, Jiyool, Kwon, Hyukjoon, Yeon, Young Joo, Kim, Taejung, Ham, Jungyeob, Kim, Young-Joo
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals cannabinoids Cannabinoids - pharmacology Cannabiorcol Cannabis - chemistry Cannabis sativa capsaicinoids cartilage Cell Line cell lines Chondrocytes - drug effects Chondrocytes - metabolism computer simulation cytotoxicity fluorescent antibody technique Interleukin-1 beta Interleukin-1beta - metabolism interleukins Male Matrix metalloproteinase Matrix Metalloproteinases - metabolism metalloproteinases mitogen-activated protein kinase NF-kappa B - metabolism Osteoarthritis Osteoarthritis - chemically induced Osteoarthritis - drug therapy p38 Mitogen-Activated Protein Kinases - metabolism protein transport quantitative polymerase chain reaction Rats Rats, Sprague-Dawley Signal Transduction - drug effects transcriptional activation Transcriptome profiling
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