Pericyte ablation causes hypoactivity and reactive gliosis in adult mice

•PDGFRβ-CreERT2 mice enable Cre-mediated recombination specifically in pericytes.•Pericyte ablation can be titrated based on tamoxifen dose.•Pericyte ablation causes hypoactivity and impairs motor function.•Pericyte ablation increases brain vessel lumen area and induces mild blood–brain barrier leak...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2025-01, Vol.123, p.681-696
Hauptverfasser:	Cashion, Jake M., Brown, Lachlan S., Morris, Gary P., Fortune, Alastair J., Courtney, Jo-Maree, Makowiecki, Kalina, Premilovac, Dino, Cullen, Carlie L., Young, Kaylene M., Sutherland, Brad A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animals Blood-Brain Barrier - metabolism Blood–brain barrier Brain - metabolism Brain - pathology Female Gliosis Gliosis - metabolism Gliosis - pathology Male Mice Mice, Inbred C57BL Mice, Transgenic Microglia - metabolism Motor Activity Motor impairment Pericyte Pericytes - metabolism Pericytes - pathology Tamoxifen - pharmacology
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