Therapeutic effects of exercise on depression: The role of microglia

•Stress-induced microglial activation mediates thepathogenesis of depression through various mechanisms.•Exercise therapy can shift the balance of microglial M1/M2 polarization and regulate inflammatory responses.•Microglia are crucial targets for exercise-based therapeutic interventions for depress...

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Veröffentlicht in:	Brain research 2025-01, Vol.1846, p.149279, Article 149279
Hauptverfasser:	Li, Li, Ren, Li, Li, Bing, Liu, Chaomeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Depression - therapy Depressive Disorder, Major - therapy Exercise Exercise - physiology Exercise - psychology Exercise Therapy - methods Humans Hypothalamo-Hypophyseal System - metabolism Inflammatory response Kynurenine pathway Major depressive disorder Microglia Microglia - metabolism Microglia - physiology Neuronal Plasticity - physiology Pituitary-Adrenal System - metabolism
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