Prognostic prediction and immune infiltration analysis based on lysosome and senescence state identifies MMP12 as a novel therapy target in gastric cancer

•Identified a 22-gene prognostic signature related to lysosomes and senescence using TCGA gastric cancer data.•Classified gastric cancers into two subtypes, Cluster 1 and Cluster 2, based on the 22 genes, with Cluster 2 exhibiting worse prognosis.•Cluster 2 displayed widespread dysregulation of lyso...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International immunopharmacology 2024-12, Vol.143 (Pt 1), p.113344, Article 113344
Hauptverfasser:	He, Ke‐Jie, Gong, Guoyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - genetics Cell Line, Tumor Cellular Senescence - genetics Chemotherapy response Copy number variation Female Gastric cancer Gene Expression Regulation, Neoplastic Humans Immune Lysosomes - metabolism Male MMP12, gene mutation Prognosis Prognostic signature Stomach Neoplasms - genetics Stomach Neoplasms - immunology Stomach Neoplasms - mortality
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!