Osteoclastic ATP6AP2 maintains β-catenin levels to prevent hyper-osteoclastic activation and trabecular bone-loss

Osteoclast (OC) formation and bone resorption are regulated by several factors, including V-ATPase, Wnt/β-Catenin, and RANKL/RANK signaling. ATP6AP2, also known as the prorenin receptor (PRR), is an accessory subunit of V-ATPase and a regulator of Wnt/β-Catenin signaling. While the V-ATPase subunit...

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Veröffentlicht in:	Journal of bone and mineral research 2024-10
Hauptverfasser:	Chen, Li, Xiong, Lei, Guo, Haohan, Feng, Xu, Zhu, Xiaojuan, Xiong, Wen-Cheng
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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